RGS2 Antibody
- Known as:
- RGS2 Antibody
- Catalog number:
- XW-7531
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- RGS2 Antibody
Related genes to: RGS2 Antibody
- Gene:
- RGS2 NIH gene
- Name:
- regulator of G protein signaling 2
- Previous symbol:
- G0S8
- Synonyms:
- -
- Chromosome:
- 1q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-01
- Date modifiied:
- 2017-04-13
Related products to: RGS2 Antibody
Related articles to: RGS2 Antibody
- Prostate cancer (PCa) remains a leading cause of cancer burden in men worldwide. Photodynamic therapy (PDT) offers a minimally invasive therapeutic option, but the molecular mechanisms underlying its anti-tumor efficacy, particularly in the context of the tumor microenvironment, are not fully elucidated. - Source: PubMed
Publication date: 2026/04/15
Zhao DeweiXi YouxiaShao JunyiDing XiaoxiaWang WenwenJin YingfenLi ZhijiaLi ZhimingZhang Xian - The regulator of G-protein signaling 2 (RGS2) plays a key role during pregnancy, whose dysregulation is closely associated with the progression of gestational disorders such as preeclampsia (PE). Therefore, investigating the downstream mechanisms regarding to RGS2-mediated biological events in trophoblasts would provide a better understanding of maintenance and progression of pregnancy. The present study describes the roles and underlying mechanisms of a regulation loop between RGS2 and the Hippo pathway in human trophoblasts, and additionally clarify that RGS2 independently mediates Connective tissue growth factor (CTGF) protein degradation by promoting its ubiquitination. At the molecular level, the ectopic expression of RGS2 deactivates the Hippo signaling but destabilizes CTGF by the Dual-specificity phosphatase 1(DUSP1)-Itchy E3 ubiquitin protein ligase (ITCH)-mediated ubiquitination of CTGF. Reciprocally, as a transcriptional co-activator, TAZ transactivates RGS2 through binding to and activating CREB. Consistently, the results could be verified in transgenic mouse placentas. Our results therefore identify the critical role of the RGS2-Hippo loop in regulating physiological function of trophoblasts during gestation. - Source: PubMed
Publication date: 2026/04/08
Zhu ChongyingXu QiangAn ZihaoZhu BingquanJin MeiyaunTang Chao - Brain metastases are a leading cause of mortality in non-small cell lung cancer (NSCLC) patients. Chemoresistance-induced metastasis remains a significant challenge in NSCLC. This study investigates whether cisplatin resistance enhances brain metastasis in NSCLC and examines the associated molecular mechanisms. - Source: PubMed
Publication date: 2026/03/14
Lin JiayiLiang LunZhu XupengLiu JunjieLan RongfengWang ZhenningZhang DanWang YingHu XiaoyanHuang ShiyuQiu LinhuiYang ShilunMou YonggaoChang JunleiYu Min - Atherosclerosis (AS) is a chronic inflammatory disease with a poor prognosis, and 5-methylcytosine (m5C) RNA modification plays a significant role in AS-induced cardio-cerebrovascular diseases (CCVDs). However, the effects of m5C modification and related genes in AS remain unclear. - Source: PubMed
Publication date: 2026/01/09
Zhao HuiKong YingDing PengfeiYang LuqunLi Ning - The GPN-loop GTPase Npa3 plays a critical role in RNA polymerase II (RNAPII) assembly and nuclear import. We employed here the npa3ΔC mutant, which supports normal RNAPII localization and function, to investigate potential links between Npa3 and target of rapamycin complex I (TORC1) signaling. The npa3ΔC cells exhibited increased sensitivity to rapamycin, a synthetic sickness interaction with tor1Δ, and a delayed growth recovery rate from rapamycin-induced G1 arrest. Co-expression analysis identified LTV1, a gene involved in TORC1 signaling and ribosome nuclear export, as one of the top genes co-expressed with NPA3. Furthermore, overexpression of eukaryotic translation initiation factor 1A (eIF1A, TIF11) or regulator of heterotrimeric G-protein signaling (RGS2) restored growth in npa3ΔC cells under rapamycin treatment. Interestingly, RGS2 also rescued growth under hygromycin B stress. Our findings suggest a genetic interplay between Npa3 and TORC1. - Source: PubMed
Publication date: 2026/01/16
Mora-García MartínDelaGarza-Varela AldaRebolloso-Gómez YolandaFélix-Pérez TaniaPeña-Gómez Sonia GRiego-Ruiz LinaSánchez-Olea RobertoCalera Mónica R