LMNA Antibody
- Known as:
- LMNA Antibody
- Catalog number:
- XW-7335
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- LMNA Antibody
Related genes to: LMNA Antibody
- Gene:
- LMNA NIH gene
- Name:
- lamin A/C
- Previous symbol:
- LMN1, CMD1A, LGMD1B, PRO1, LMNL1
- Synonyms:
- HGPS, MADA
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-09
- Date modifiied:
- 2019-04-23
Related products to: LMNA Antibody
Related articles to: LMNA Antibody
- Fluorescent in situ sequencing involves imaging-based sequencing by synthesis in intact cells or tissues to reveal target nucleotide sequences inside each cell. Often, the target sequences are barcodes that indicate a perturbation (e.g., CRISPR guide or genetic variant) delivered to the cell. However, processing in situ sequencing data presents a considerable challenge, requiring stitching and aligning tens of thousands of images with millions of cells, detecting small amplicon colonies across sequencing cycles, and calling reads. To address these challenges, we introduce STARCall: STitching, Alignment and Read Calling for in situ sequencing, a software package that analyzes raw in situ sequencing images to produce a genotype-to-phenotype mapping for each cell. STARCall improves upon previous solutions by combining stitching and alignment of images into a single step that minimizes both inter-cycle and intra-cycle alignment error. STARCall also improves detection and extraction of sequencing reads, incorporating filters and normalization to combat background fluorophore signal. We compare STARCall to other methods using a diverse set of images that include commonly encountered imaging problems such as variable intensity across channels and cycles and high levels of background. Specifically, this comprises ~250,000 images from a pooled screen of ~3,500 barcoded LMNA variants expressed in U2OS cells and ~1,200 barcoded PTEN variants in induced pluripotent stem cells (iPSC) and iPSC-derived neurons. Overall, STARCall aligned more than 50% of tiles with <1 pixel residual misalignment on all nine image sets, outperforming alternative packages by 14-35%. STARCall also yielded an 8-40% increase in genotyped cells due to improved filtering and normalization methods that address background fluorescence. STARCall can call tools like CellPose to segment cells and CellProfiler to compute cell features from the phenotyping images. STARcall is open-source and freely available, providing a robust solution for the analysis of in situ sequencing data. - Source: PubMed
Publication date: 2026/04/27
Bradley Nicholas JPendyala SriramPartington KatieFowler Douglas M - Familial partial lipodystrophy type 2 (FPLD2) is a rare autosomal dominant laminopathy caused by LMNA gene variants. It is characterized by progressive gluteofemoral lipoatrophy and severe metabolic derangements, including insulin resistance and metabolic dysfunction-associated steatotic liver disease. - Source: PubMed
Publication date: 2026/04/10
Mendoza CarolinaCano RaquelBurgos LuisSilvera Carlos Arturo - Monogenic lipodystrophy is a metabolic disorder that predisposes to diabetes and cardiovascular disease, yet its true prevalence and clinical spectrum remain uncertain. We used a genotype-first approach with an aim to estimate the prevalence, phenotypic spectrum, risk of cardiometabolic disorders and all-cause mortality associated with monogenic lipodystrophy in the population. We also assessed how these clinically unselected cases differ from clinically identified cases. - Source: PubMed
Publication date: 2026/04/18
Sharp Luke NColclough KevinMurray Leech JacquesEvans Amy VHattersley Andrew TWeedon Michael NBrown Rebecca JPatel Kashyap A - Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) decreases, yet whether this atrophy exacerbates cold stress and triggers systemic aging remains unclear. Here we show that adipocyte-specific expression of the Lmna mutation in male mice leads to progressive WAT atrophy, accelerates aging, and shortens lifespan, whereas female mice remain unaffected. This lipoatrophy exacerbates cold stress, triggering cyclooxygenase-2 (COX-2) upregulation in WAT, and increased prostaglandin E production, which mediates the elevation of core body temperature (CBT). Inhibiting COX-2 by celecoxib or thermotherapy by housing the lipoatrophic mice at 26 °C (normally 22 °C) ameliorates cold stress, restores CBT, reduces aging features, and extends lifespan. Our findings reveal that subcutaneous WAT atrophy and subsequent CBT elevation induced by chronic mild cold stress are drivers of systemic aging in male mice, identifying thermotherapy as a potential regimen for progeria. - Source: PubMed
Publication date: 2026/04/18
Liu ZuojunHu WenjingTan XiaoqingSun ShiminHuang XinMeng YuanZhao NanWang MingWu WeiweiQian MinxianTang XiaolongPang QiuxiangWang ZimeiSu WenLiu Baohua - Emery-Dreifuss muscular dystrophy (EDMD) is a rare genetic disorder characterized by early-onset joint contractures, progressive muscle atrophy, and cardiac abnormalities. Patients with EDMD carrying sequence variations often exhibit severe cardiac manifestations, including frequent atrioventricular block and ventricular tachycardia. Approximately 20% of those patients may ultimately require heart transplantation. The molecular mechanisms by which sequence variations lead to EDMD remain unknown. - Source: PubMed
Publication date: 2026/04/17
Fan HangpingWang XiaochenLiu XujieZhao JiuxiaoZhang YuanYang ZongkuaiWang HaoGong JunhaoLi LingyingJin JiaminGuo YuxuanGong TingyuZhuang LenanKe QingLiang Ping