IL16 Antibody
- Known as:
- IL16 Antibody
- Catalog number:
- XW-7288
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- IL16 Antibody
Related genes to: IL16 Antibody
- Gene:
- IL16 NIH gene
- Name:
- interleukin 16
- Previous symbol:
- -
- Synonyms:
- LCF, IL-16, prIL-16, HsT19289, FLJ42735, FLJ16806
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: IL16 Antibody
Related articles to: IL16 Antibody
- SARS-CoV-2 infection can induce a hyperinflammatory response through excessive cytokine release, contributing to disease severity and mortality. NRICM101, a government-endorsed multi-herbal traditional Chinese medicine formula, has shown promising immunomodulatory and antiviral effects in preclinical studies. However, clinical evidence on its effect on inflammatory biomarkers in COVID-19 patients remains limited. - Source: PubMed
Publication date: 2026/09/30
Wang Ying-ChuanYao Ya-HsinLin Sunny Jui-ShanChiu Chun-Hsiang - To investigate the effects of low bicarbonate alkalinity on intestinal health of Scylla paramamosain, we systematically evaluated the growth survival, intestinal antioxidant enzyme activities, and expression profiles of genes involved in immunity, inflammation, apoptosis and osmoregulation under low alkalinity conditions. Meanwhile, integrated intestinal microbiome and metabolome analyses were performed. The results showed that low bicarbonate alkalinity significantly reduced the survival and molting rates of S. paramamosain. It markedly elevated the activities of intestinal SOD, CAT and GSH-Px, as well as the expression levels of inflammation-related genes (IL-16, RELISH, LITAF), apoptosis-related genes (CASPASE7, BAX, BCL2) and osmoregulation-related genes (NKA, NHE, Cl/HCO₃), while suppressing the expression of immune genes (proPO, ALF1, LZM) (P < 0.05). Low bicarbonate alkalinity disrupted the intestinal microbiota structure of S. paramamosain, accompanied by a decreased abundance of the phylum Bacteroidota and a significant increase in the abundance of the genus Klebsiella (P < 0.05). A total of 714 differential metabolites were identified by metabolomic analysis, which were mainly annotated into Fatty Acyls, Glycerophospholipids, and Steroids and steroid derivatives. Multiple carbohydrate metabolism pathways were significantly enriched and participated in the regulation of Fructose 6-Phosphate (F6P). Integrated microbiome-metabolome analysis revealed that N,N-dimethyl arachidonoyl amine (NDAA) may cooperate with intestinal microorganisms to regulate the stress tolerance of S. paramamosain under low bicarbonate alkalinity stress. Based on the physiological and biochemical characterization of the intestine, this study elucidated the adaptive characteristics of S. paramamosain under low bicarbonate alkalinity. The findings provide important theoretical basis and practical significance for the saline-alkaline aquaculture of S. paramamosain. - Source: PubMed
Publication date: 2026/10/01
Zhao YumeiChe ChenxiHong DonggeZhuang YiQin KangxiangLi YuntaoChen YumengWang ChunlinMu ChangkaoWang Huan - Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease in which inflammatory mechanisms are involved in disease development and progression. Polymorphisms in cytokine-related genes may influence susceptibility to T2DM, yet evidence in Vietnamese individuals remains scarce. This study was designed to investigate whether IL16 rs11556218 and IL1B rs16944 are associated with T2DM in Kinh Vietnamese adults. - Source: PubMed
Publication date: 2026/09/28
Lam Quynh AiPhan Hen HuuLe Linh Hoang GiaDo Minh Duc - Systemic inflammation contributes to the pathobiology of multiple sclerosis (MS), yet serum biomarker data from Middle Eastern populations remain limited. This study evaluated serum levels of IL-6, IL-16, IL-18, and IL-36 in Saudi adults with MS compared with matched healthy controls and examined associations with disease duration, phenotype, treatment, and disability. This single-center, cross-sectional, matched case-control study enrolled 26 MS patients and 26 age- and sex-matched controls. Serum cytokines were measured by ELISA. Disability was assessed using EDSS and the Timed 25-Foot Walk (T25FW). Matched comparisons used Wilcoxon signed-rank tests; subgroup comparisons used Wilcoxon rank-sum or Kruskal-Wallis tests; associations used Spearman's correlation. No correction for multiple comparisons was applied given the exploratory design. All four interleukins were higher in MS patients than in controls ( < 0.001). Age correlated with EDSS (r = 0.573, = 0.002) and T25FW (r = 0.464, = 0.014). Only IL-6 showed a notable correlation with disability, with T25FW (r = 0.53, = 0.008) and, weaker, EDSS (r = 0.38, = 0.052); IL-18 showed a weak, non-significant correlation with T25FW (r = 0.35, = 0.126); IL-16 and IL-36 showed no relevant associations. IL-16 was higher in newly diagnosed than in long-standing cases ( = 0.012); no differences by phenotype or treatment were observed for any marker. Serum IL-6, IL-16, IL-18, and IL-36 were elevated in Saudi MS patients versus controls. IL-6 alone showed a modest, unadjusted association with disability, supporting its evaluation as a candidate biomarker in larger, longitudinal, covariate-adjusted cohorts. These findings are hypothesis-generating and should not be interpreted as evidence of independent or clinically actionable biomarker utility. - Source: PubMed
Publication date: 2026/09/01
Alrahimi JehanMualla YaraAlhebshi AlawiahAlnajashi Hind AZaher Kawther - Endometriosis is a multifaceted disease, causing debilitating pelvic pain in some patients, while being completely asymptomatic in others. The pathophysiology of endometriosis pain is not well understood and poorly correlated to stage. We hypothesized that this clinical heterogeneity may be explained by examining differences in gene expression. We performed RNA sequencing of 27 formalin-fixed, paraffin-embedded peritoneal biopsies from 9 symptomatic (Sx) and 10 asymptomatic (ASx) subjects. 890 genes were differentially expressed between Sx and ASx samples. Of these, the most significant including genes involved inflammatory signaling (IL16, IL17RA, JAK3, SMPD3, RELT), cell adhesion (OLFML1, CDON, VCAN), and neuromodulation (SEMA6D, ADRA2C, SLC7A5). Gene Set Enrichment Analysis identified functional enrichment in 22 gene ontology (GO) pathways, of which 7 represented immunologic pathways. Weighted Gene Correlation Network Analysis (WGCNA) identified 11 co-expression modules significantly correlated with symptomaticity, including one module strongly enriched for immunologic/inflammatory functions. Of all molecules identified as associated with pain, IL16 expression also correlated with symptom severity when cases were stratified into mild vs. severe pain based on clinical criteria. These findings suggest that endometriotic lesions of symptomatic subjects are characterized by distinct molecular signatures, including altered expression of inflammatory pathways, highlighting potential mechanisms underlying symptom variability and identifying candidate pathways for future therapeutic interventions. - Source: PubMed
Publication date: 2026/09/10
Mamillapalli RamanaiahLi Howard JApelian ShantKumar MonishWang Sarah FPondugula NishitaCampos Gabriela de QueirozSayeed SumaiyaCho YongheeTaylor Hugh S