MAPK1 Antibody
- Known as:
- MAPK1 Antibody
- Catalog number:
- XW-7183
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- MAPK1 Antibody
Related genes to: MAPK1 Antibody
- Gene:
- MAPK1 NIH gene
- Name:
- mitogen-activated protein kinase 1
- Previous symbol:
- PRKM2, PRKM1
- Synonyms:
- ERK, ERK2, p41mapk, MAPK2
- Chromosome:
- 22q11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-05
- Date modifiied:
- 2019-04-23
Related products to: MAPK1 Antibody
Related articles to: MAPK1 Antibody
- Germline pathogenic variants that activate the Ras/mitogen-activated protein kinase (MAPK) pathway cause neurodevelopmental disorders called 'Rasopathies'. Because many affected proteins directly regulate Ras, causative mutations may alter other Ras-dependent pathways in addition to MAPK signaling. To better understand which Rasopathy sequelae result from hyperactivation of downstream MAP kinases, we engineered mice with a gain-of-function mutation in the terminal MAP kinase gene Mapk1, which encodes ERK2 and is associated with the recently described genetic syndrome MAPK1-related Rasopathy (MRR). Mapk1 mutant mice successfully modeled key aspects of the human MRR phenotype, including small stature, facial dysmorphism, and impaired cognitive function. Importantly, they recapitulated phenotypes identified in Rasopathy models with upstream Ras activation, such as neurofibromatosis type 1 (NF1): oligodendrocyte lineage defects, reactive astrogliosis, memory deficits, and hypersensitivity to sensory stimuli. These findings emphasize the importance of downstream MAPK signaling in the pathophysiology of neurocognitive symptoms observed in Rasopathy syndromes. - Source: PubMed
Publication date: 2026/04/28
Grover Kassidy ECappel Zoe RVolz AveryCotella Evelin MSmallwood KellyBerryhill Christine ARaje Kimaya RFisher Austen ACasper Mary Claire TNardini DianaRizvi Tilat ASalazar Rosa MWooten AshleyWilliams Michael TVorhees Charles VRomick Lindsey EGreis Kenneth DHu Yueh-ChiangMiles Linde AAngus Steven PRatner NancyPrada Carlos EWeaver K NicoleWaclaw Ronald RRobinson J Elliott - Skeletal muscle development directly determines growth efficiency and meat quality in livestock. Circular RNAs (circRNAs) and their encoded micropeptides are emerging regulators of this process, yet their roles in goats remain poorly understood. Through integrated ribosome profiling (Ribo-seq) and circRNA-seq of goat skeletal muscle satellite cells (SMSCs), we identified a MAPK1-derived protein-coding circRNA, circMAPK1 (novel-circ-0039015). Functional analyses revealed that circMAPK1 overexpression suppressed SMSCs proliferation and myogenic differentiation. Mechanistically, circMAPK1 encodes a 110-amino-acid micropeptide (circMAPK1-110aa) that binds Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) and reduces MAPK1/3 phosphorylation, thereby attenuating Mitogen-Activated Protein Kinase (MAPK) signaling. Importantly, pharmacological activation of the MAPK pathway with C16-PAF partially restored muscle cell growth and differentiation. These findings establish circMAPK1 as a negative regulator of goat skeletal muscle development and highlight its encoded micropeptides as a potential molecular target. By uncovering a new regulatory mechanism of muscle growth, this study provides valuable insights for breeding strategies aimed at enhancing meat yield and quality in goats. - Source: PubMed
Publication date: 2026/04/27
Pan QianqianLou MengyuZhu MengkangHe XiaohongLan XianyongZhang SihuanLing Yinghui - Naru-3 Wei Pill is a traditional Mongolian Medicine (TMM) that has anti-inflammatory, analgesic, and antibacterial effects. The present study aimed to demonstrate the anti-inflammatory and analgesic effect of Naru-3 Wei Pill, identify the core components and key targets and determine the pharmacological basis and mechanism of its blood-borne components. - Source: PubMed
Han ZhiqiangKang HusileZhang AidiQigeqin Baolechaolu Wulanqiqige Wang HuanXu YanhuaHaSi Anda Xue Lan - This study aimed to explore the expression, function, and regulatory mechanism of exosomal miR-106b-5p in osteoporosis (OP), to identify a novel diagnostic biomarkers and therapeutic targets. - Source: PubMed
Xia Ming-HuiLu Yi-HuaWu Long-FeiDeng Fei-YanLei Shu-Feng - Blood-Heat syndrome is a core syndrome of Traditional Chinese Medicine (TCM) in Henoch-Schönlein purpura nephritis (HSPN), yet its biological basis remains unclear. This study aimed to systematically elucidate the scientific basis of Blood-Heat syndrome within the context of HSPN and to identify its objective biomarkers using a multidimensional biological approach. - Source: PubMed
Publication date: 2026/04/10
Xu ShuangXu YanBi YuefengDing YingZhang XiaXi LeyingRen Xianqing