HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.
- Known as:
- HSD17B1 favors reduction estrogens androgens. 20-a-HSD activity. uses preferentially NADH.
- Catalog number:
- 29-632
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- HSD17B1 favors the reduction estrogens and androgens. also has 20-alpha-HSD activity. uses preferentially NADH.
Related genes to: HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.
- Gene:
- HSD17B1 NIH gene
- Name:
- hydroxysteroid 17-beta dehydrogenase 1
- Previous symbol:
- EDHB17, EDH17B2
- Synonyms:
- HSD17, MGC138140, SDR28C1
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2016-06-03
- Gene:
- NDUFA6 NIH gene
- Name:
- NADH:ubiquinone oxidoreductase subunit A6
- Previous symbol:
- -
- Synonyms:
- B14, LYRM6, CI-B14, NADHB14
- Chromosome:
- 22q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-30
- Date modifiied:
- 2015-11-20
Related products to: HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.
Related articles to: HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.
- Female infertility is an increasing global public health concern. Growing evidence suggests that exposure to organophosphate flame retardants (OPFRs) may contribute to reproductive dysfunction. However, the OPFRs most strongly associated with female infertility and the potential molecular pathways underlying these associations remain unclear. This study employed an integrated framework combining epidemiological analysis, network toxicology, molecular docking, and adverse outcome pathway (AOP) construction to investigate the association between OPFR exposure and female infertility and to explore plausible underlying mechanisms. Cross-sectional data from 1044 women in the National Health and Nutrition Examination Survey (NHANES) 2013-2018 cycles were analyzed using multivariable logistic regression, restricted cubic spline (RCS), Quantile g-computation (Qgcomp), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR). Diphenyl phosphate (DPhP) was consistently identified as the OPFR metabolite most strongly positively associated with female infertility and showed the greatest relative influence across the mixture models. Network toxicology prioritized six steroidogenic enzymes (CYP11A1, CYP17A1, CYP19A1, HSD3B1, HSD17B1, and HSD17B2) as candidate molecular targets, and molecular docking predicted favorable interactions of DPhP and its parent compound triphenyl phosphate (TPhP) with these proteins. Integration of these computational findings with existing AOPs suggested a plausible mechanistic framework involving perturbation of steroidogenesis, altered estradiol biosynthesis, and disruption of androgen-estrogen homeostasis, which may contribute to impaired female reproductive function. These findings provide cross-sectional evidence for an association between DPhP exposure and female infertility and generate mechanistic hypotheses regarding TPhP/DPhP-associated reproductive effects that warrant further experimental and prospective validation. - Source: PubMed
Publication date: 2026/09/08
Zhang JiayiYang YuxinGao ZidongChen XinwenPang YujiaGu YanjieZhou YingZong LinhaoMa FeiCheng JieGuan Miao - Buffaloes do not exhibit overt estrus signs particularly during summer, leading to a significant economic loss to farmers. Previous studies have identified several candidate transcripts (HSP70, TIMP1, TLR4 and HSD17B1), abundant in buffalo saliva during estrus stage. However, there is no widely applicable technology for estrus detection targeting these transcripts. Therefore, the present study aimed to develop reverse transcription loop mediated isothermal amplification (RT-LAMP) assays for these candidate transcripts using buffalo saliva. Saliva samples were collected from 10 cyclic buffaloes and RT-LAMP assays were optimized for salivary RNA as well as direct saliva. Among the four candidate transcripts, HSP70 showed a statistically significant colour change (p-value = 0.0191) at the estrus stage compared to the diestrus stage. This abundance of HSP70 was also supported in large simulated population datasets (10,000 animals) generated using R. Further, the RT-LAMP assays were tested using direct saliva without RNA isolation, and the colour change in the samples during estrus suggested the feasibility of estrus identification using direct saliva, overcoming the tedious step of RNA isolation. The detection of HSP70 using either direct saliva or salivary RNA indicated its potential as a marker for estrus identification. Similarly, TLR4 appeared to be another potential biomarker for RT-LAMP reaction using direct saliva, but it needs further validation in both RNA and direct saliva samples. Overall, the proof-of-concept on RT-LAMP assays optimized for salivary transcripts in the present study would be useful for estrus identification in tropical production systems following further validation on a larger sample size. - Source: PubMed
Publication date: 2026/09/08
Kaushik NikitaJoshi MansiBaithalu Rubina KumariPaul Rajani KumarSingh DheerOnteru Suneel Kumar - Phoenixin-14 is a neuropeptide that has been shown to bind to GPR173 for biological functions. Its expression has been shown in various tissues, including the ovaries of porcine, human, and rat. However, no information is available on its expression in postnatal mouse testes. Phoenixin-14 is derived from the gene Smim20. Here we report that Smim20 and Gpr173 mRNA expression shows a decline from PND7 to PND65, with the highest expression at PND7 and the lowest at PND65. Due to the limited availability of commercial phoenixin-14 antibody, we raised an antibody in a rat and validated it by ELISA, immunohistochemistry and dot blot assay for immunohistochemical localization. Immunolocalization of phoenixin-14 and GPR173 showed their presence in the seminiferous tubules and Leydig cells. The Leydig cells of PND65 mice showed strong immunostaining of GPR173 and moderate staining of phoenixin-14. Our co-localization study showed that phoenixin-14 and GPR173 are co-expressed in the testis. These results provide evidence that phoenixin-14 and GPR173 expression are regulated in the testis during postnatal developmental stages. The presence of phoenixin-14 and GPR173 in the germ cells suggests their possible role in and in Leydig cells in steroidogenesis. The gene expression of Cyp11a1 and Cyp17a1 was also elevated in PND28-PND65, which coincides with elevated testosterone levels reported elsewhere. Thus, postnatal changes in phoenixin-14 and GPR173 could also be involved in the regulation of testosterone secretion. Our in vitro study further supports that phoenixin-14 stimulates testosterone secretion at two different doses (10 and 100 nM); however, the lower dose showed higher secretion along with elevated gene expression of steroidogenic markers (Cyp11a1, Cyp17a1, Star and Hsd17b1). In conclusion, testicular phoenixin/GPR173 could be regulating testosterone secretion at different postnatal stages. - Source: PubMed
Publication date: 2026/09/07
Marak Dombera KGurusubramanian GuruswamiRoy Vikas Kumar - As key medicinal targets, ginseng and Angelica sinensis have demonstrated potential efficacy in the treatment of Premature Ovarian Failure (POF). This study identified the key targets and further explored their potential causal links with POF using Mendelian randomization (MR) analysis. - Source: PubMed
Publication date: 2026/08/24
Yang ShuangLiao Wen-JingZhao PuQiu Ze-JingHe Qi-DaZou Yu-CongCai Jiao-YingGan Wen-Jun - Estrone (E1), a ubiquitous environmental estrogen, poses a potential threat to the reproductive health of aquatic organisms. To evaluate the inducing effect of E1 exposure on gonadal feminization in male Siniperca chuatsi, male fish were exposed to 0, 0.01, 0.1, and 1 μg/L E1 for 60 days. The effects of E1 exposure on serum sex hormones, gonadal histological sections, vasa in situ hybridization, cell apoptosis, and gene expression in S. chuatsi were systematically examined. The results showed that 0.1 μg/L E1 treatment significantly inhibited testicular germ cell development, while 1 μg/L E1 treatment induced gonad histological feminization in 80% of male fish, with early vitellogenic oocytes appeared. Additionally, E1 exposure caused significant changes in serum sex hormones: 11-ketotestosterone levels significantly decreased, while immunoreactive estradiol levels significantly increased. Vasa gene in situ hybridization showed positive signals and TUNEL cell apoptosis revealed no obvious apoptotic signals in E1-induced histologically feminized gonads. Further molecular analysis revealed that sex regulation and development-related genes were involved in the E1-mediated gonadal feminization process: the expression of key male sex determination genes (dmrt1, amh, gsdf, sox9) and steroidogenic support genes (star, fshr) was significantly down-regulated, while expression of key female differentiation genes (bmp15, foxl2, cyp19a1a, hsd17b1) and germ cell development genes (sox19a, dazl, vasa, ccne2, sox3) was significantly up-regulated. Collectively, these findings demonstrate that E1 exposure induces histological testicular feminization in male S. chuatsi in a dose-dependent manner, concomitant with transcriptional downregulation of male differentiation genes and upregulation of female differentiation genes. - Source: PubMed
Publication date: 2026/08/28
Chen KaichunZhang YongqingLi WeibinYang HaiyingDeng ZiyanCai GuojunXie ZihangLi QiangHan Chong