DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary
- Known as:
- DEAD box proteins, characterized conserved motif L-aspartic acid-L-gutamic acid-alanine-L-aspartic acid (DEAD), putative RNA helicases. implicated a number cellular processes involving alteration RNA secondary detector ab
- Catalog number:
- 25-354
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- DEAD box proteins characterized the conserved motif Asp-Glu-Ala-Asp (DEAD) are putative RNA helicases. They implicated number cellular processes involving alteration secondary
Related genes to: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary
- Gene:
- ADAT2 NIH gene
- Name:
- adenosine deaminase tRNA specific 2
- Previous symbol:
- DEADC1
- Synonyms:
- dJ20N2.1, TAD2
- Chromosome:
- 6q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2019-01-18
Related products to: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary
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- It is documented that antigens can induce immune responses able to regulate complex diseases. Conversely, the dysregulated inflammatory response in leprosy increases morbidity and leads to reactional episodes, impairing the disease pathogenesis. The goal of this study was to evaluate the potential of the (Sm29) antigen in regulating the immune response in leprosy through a transcriptome study across clinical reactional forms: reversal reaction (RR), and erythema nodosum leprosum (ENL), and without reaction (WR). - Source: PubMed
Publication date: 2026/06/01
Karoline Silva Joycede Farias Lucas NevesLago TainãCardoso Luciana Dos SantosKhouri RicardoMachado Paulo RobertoCastellucci Léa Cristina - BACKGROUND: Adenosine-to-Inosine (A-to-I) modification is one of the most common transfer RNA (tRNA) modifications in humans. However, the role of A-to-I tRNA modification in colorectal cancer (CRC) remains poorly understood. METHODS: tRNA modification was profiled by LC-MS in paired CRC and adjacent normal tissues (N = 70). The clinical significance of adenosine deaminase tRNA specific 2 (ADAT2) was evaluated using in-house (N = 157) and TCGA cohorts (N = 283). The function of ADAT2 in CRC was determined in intestine-specific ADAT2 knockout mice. Mechanism of ADAT2 was assessed by integrated RNA-sequencing, tRNA-sequencing, and ribosome-sequencing analyses. RESULTS: Among 32 tRNA nucleotide modifications, A-to-I modification is the top enriched tRNA modification in CRC tumors compared to paired adjacent normal tissues (P < 0.001). Consistently, A-to-I modification enzyme ADAT2 is elevated in CRC and associated with poor patient survival in independent patient cohorts. Functionally, ADAT2 overexpression promotes malignant phenotypes in CRC cells and patient-derived CRC organoids, whereas ADAT2 knockout exerts opposite effects. Intestine-specific ADAT2 knockout mice showed attenuated colorectal tumorigenesis. Integrated sequencing identified that ADAT2 boosts translation efficiency of genes highly dependent on A-to-I codons, specifically enriched in WNT/β-catenin signaling. We revealed HDAC7 as a downstream target, whereby ADAT2 promotes HDAC7 translation in an A-to-I dependent fashion. HDAC7 interacts with β-catenin, leading to its activation and nuclear translocation. For translational value, ADAT2 promotes chemoresistance in CRC, and targeting ADAT2 by VNP-encapsulated ADAT2-siRNA promoted Oxaliplatin and 5-Fluorouracil efficacy to suppress CRC growth. CONCLUSIONS: ADAT2-driven tRNA A-to-I modification promotes CRC tumorigenesis and chemoresistance via HDAC7-WNT/β-catenin axis, and is an independent prognostic factor. - Source: PubMed
Publication date: 2026/03/17
Cheng Cillian HJi FenfenShen JianmingJiao YingChen DanyuYang HuanYe LiufangTao RuizhiWei QinyaoKang WeiYu JunWong Chi Chun - RNA modification enzymes (RMEs) are key post-transcriptional regulators that impact RNA stability, translation, and splicing. Dysregulation of RMEs is closely associated with tumor initiation and progression. However, their global regulatory patterns and clinical relevance across cancer types remain incompletely characterized. - Source: PubMed
Publication date: 2026/01/28
Zhan QianqianSun HuihuiWang XiangtingLiang Xiaolin - Carcass traits are among the most critical production characteristics in broiler chickens. Therefore, the precise identification of genetic variants and candidate genes affecting these traits is highly valuable for enhancing breeding efficiency and overall productivity in poultry. In this study, a genome-wide association study (GWAS) was conducted to analyse seven carcass traits in 1 498 cocks from a Chinese indigenous yellow-feathered meat chicken population, which had been subjected to three generations of selective breeding for improved BW and feed conversion ratio. The assessing traits included breast muscle weight (BMW), BWs at 42 and 56 days (BW42, BW56), carcass weight (CW), eviscerated weight (EW), eviscerated weight with giblets (EWG), and leg weight (LW). Six significant single-nucleotide polymorphism (SNP) sites were identified by using the "Jingxin No. 1″ 55 K SNP microarray and bioinformatic analysis. These SNPs were annotated to six candidate genes on chromosomes 1, 2, 3, 4, 9, and Z, including SPHKAP, ALCAM, CMTM7, ADAT2, LIMCH1 and AP3B1, with the variant in the SPHKAP gene harboured a frameshift deletion in the coding region. Our study identified novel variants related to chicken carcass traits, which provide a new insight into the genetic mechanism of chicken carcass traits. These trait-associated genetic variants could facilitate the selection of more efficient broilers. - Source: PubMed
Publication date: 2025/12/23
Pan ZGeng HLi DCheng XLiu Y - Transfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 is an important modification that expands anticodon-codon recognition at the wobble position and is required for normal mRNA translation. The relevance of tRNA editing in cancer remains unexplored. Here we show that the genes encoding the ADAT2/3 deaminase complex, responsible for A-to-I tRNA editing in humans, are commonly amplified and/or overexpressed in several tumor types including liposarcoma (LPS). We find that LPS cell growth and tumorigenicity is dependent on ADAT2/3 tRNA editing activity. Mechanistically, we find decreased tRNA editing upon ADAT2 depletion, defective translation of a subset of mRNAs, and altered protein homeostasis. Thus, ADAT2 promotes oncogenesis and the translation of growth promoting mRNAs that are enriched in NNC codons that lack cognate tRNAs and therefore depend on A-I tRNA editing for decoding and mRNA translation. Our results identify ADAT2/3 as a potential new cancer therapeutic target. - Source: PubMed
Publication date: 2025/09/02
Ramirez-Moya JuliaAntika Titi RindiLiu QiXiong XushenAli RajaGutierrez AlejandroGregory Richard I