ZNF75A belongs to the krueppel C2H2-type zinc-finger protein family. It contains 5 C2H2-type zinc fingers and 1 KRAB domain. ZNF75A may be involved in transcriptional regulation.
- Known as:
- ZNF75A belongs krueppel C2H2-classification zinc-finger protein family. contains 5 C2H2-classification zinc fingers 1 KRAB domain. ZNF75A involved transcriptional regulation.
- Catalog number:
- 25-336
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- ZNF75A belongs the krueppel C2H2-type zinc-finger protein family. contains 5 zinc fingers and 1 KRAB domain. may involved transcriptional regulation.
Related genes to: ZNF75A belongs to the krueppel C2H2-type zinc-finger protein family. It contains 5 C2H2-type zinc fingers and 1 KRAB domain. ZNF75A may be involved in transcriptional regulation.
- Gene:
- ZNF75A NIH gene
- Name:
- zinc finger protein 75a
- Previous symbol:
- -
- Synonyms:
- FLJ31529
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-07
- Date modifiied:
- 2016-10-05
Related products to: ZNF75A belongs to the krueppel C2H2-type zinc-finger protein family. It contains 5 C2H2-type zinc fingers and 1 KRAB domain. ZNF75A may be involved in transcriptional regulation.
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- Different subtypes of hernia exhibit significant familial aggregation. However, the genetic correlations among different hernia subtypes, as well as their shared and subtype-specific candidate genes still remain unclear. - Source: PubMed
Publication date: 2026/01/07
Shi HekaiMa HuiLi QijunMa JunliangPeng XiaoyuYang DongchaoSong ZhichengGu Yan - Previous research has found that a quantitative trait locus exists affecting calving and conformation traits on Bos taurus autosome 18 that may be related to increased calf birth weights, which are not routinely recorded in the United States. Birth weight data from large, intensively managed dairies in eastern Germany with management systems similar to those commonly found in the United States were used to develop a selection index predictor for predicted transmitting ability (PTA) of birth weight. The predictor included body depth, rump width, sire calving ease, sire gestation length, sire stillbirth, stature, and strength. Genetic and phenotypic correlations and heritabilities from the United States were substituted for the German values, and birth weight PTA predicted for 31,984 bulls with US genetic evaluations. A genome-wide association study was conducted on the predicted birth weight PTA with the 2-step genomic BLUP procedure used for routine evaluations in the United States. Allele substitution effects were predicted for 43,188 single nucleotide polymorphisms (SNP). Genotypes were available for 53,644 predictor animals. Gene set enrichment analysis was performed on the 100 SNP that had the largest effects expressed in additive genetic standard deviations. Several SNP related to growth and development were found among the 25 SNP with the largest effects, including markers located within or near (≤ 100 kbp) ABCA12, FLRT2, LHX4, MAP3K5, NRAC, NTNG1, PIGN, and ZNF75A. The gene set enrichment analysis identified the Kyoto Encyclopedia of Genes and Genomes "Regulation of actin cytoskeleton" pathway (bta04810) as being enriched. That pathway includes the ROCK gene, which is involved in placental function in the human, as well as other developmental genes (e.g., FAK and PAK). Prediction equations derived from one population are useful for identifying genes and gene networks associated with phenotypes that are not directly measured in a second population. This approach will identify only genes associated with the traits used to construct the birth weight predictor, and not loci that affect only birth weight. - Source: PubMed
Publication date: 2014/03/05
Cole J BWaurich BWensch-Dorendorf MBickhart D MSwalve H H - We have previously reported (Villa et al. (1993), Genomics 18: 223) the characterization of the human ZNF75 gene located on Xq26, which has only limited homology (less than 65%) to other ZF genes in the databases. Here, we describe three human zinc finger genes with 86 to 95% homology to ZNF75 at the nucleotide level, which represent all the members of the human ZNF75 subfamily. One of these, ZNF75B, is a pseudogene mapped to chromosome 12q13. The other two, ZNF75A and ZNF75C, maintain an ORF in the sequenced region, and at least the latter is expressed in the U937 cell line. They were mapped to chromosomes 16 and 11, respectively. All these genes are conserved in chimpanzees, gorillas, and orangutans. The ZNF75B homologue is a pseudogene in all three great apes, and in chimpanzee it is located on chromosome 10 (phylogenetic XII), at p13 (corresponding to the human 12q13). The chimpanzee homologue of ZNF75 is also located on the Xq26 chromosome, in the same region, as detected by in situ hybridization. As expected, nucleotide changes were clearly more abundant between human and orangutan than between human and chimpanzee or gorilla homologues. Members of the same class were more similar to each other than to the other homologues within the same species. This suggests that the duplication and/or retrotranscription events occurred in a common ancestor long before great ape speciation. This, together with the existence of at least two genes in cows and horses, suggests a relatively high conservation of this gene family. - Source: PubMed
Villa AStrina DFrattini AFaranda SMacchi PFinelli PBozzi FSusani LArchidiacono NRocchi MVezzoni P