ZNF280D may function as a transcription factor.

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Known as:: ZNF280D function a transcription factor.
Catalog number:: 25-301
Product Quantity:: 0.05 mg
Category:: -
Supplier:: Prosci
Gene target:: ZNF280D may function transcription factor.

Related genes to: ZNF280D may function as a transcription factor.

Gene:: ZNF280D ^{NIH gene}
Name:: zinc finger protein 280D
Previous symbol:: SUHW4
Synonyms:: FLJ20086, ZNF634
Chromosome:: 15q21.2
Locus Type:: gene with protein product
Date approved:: 2004-06-02
Date modifiied:: 2018-11-22

Related products to: ZNF280D may function as a transcription factor.

Related articles to: ZNF280D may function as a transcription factor.

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Tianhua mutton sheep.
Sheep have diversified into distinct breeds worldwide through both natural adaptation and human-driven selection, with hybridization serving as an effective strategy for rapid trait improvement. The Tianhua mutton sheep (TMS) is a novel breed derived from crossing South African Mutton Merino (SAMM) with Gansu alpine fine-wool sheep (GAFS). After nearly two decades of selective breeding, TMS has developed great meat quality traits and impressive cold tolerance at high altitudes. To study the genetic mechanism and provide new insights into phenotypic variation, we analyzed the genetic diversity, population structure, and selective signatures of TMS based on whole-genome sequencing of 55 TMS, 11 SAMM, and 197 public sheep genomes worldwide. - Source: PubMed
Publication date: 2026/01/31
Jiang BeixiangZeng JizeChi HuanpengShan JingfangZhang XueyingFeng QianjieLi FadiYue XiangpengFu Weiwei
Multi-proteomic profiling of the varicella-zoster virus-host interface reveals host susceptibilities to severe infection.
Varicella-zoster virus (VZV) infects most humans and causes chickenpox, shingles and central nervous system pathologies. The molecular basis for these phenotypes remains elusive. Here we conducted a multi-proteomic survey on 64 individual VZV proteins and infection-induced perturbations in a neuronal cell line, identifying 900 interactors and 3,618 regulated host proteins. Data integration suggested molecular functions of viral proteins, such as a mechanism for the ORF61-mediated IFI16 degradation via the recruitment of E3 ligase co-factors. Moreover, we identified proviral host factors (MPP8 and ZNF280D) as potential targets to limit infection. Integration of exome sequencing analysis from patients with VZV-associated central nervous system pathologies identified nephrocystin 4 as a viral restriction factor, and its S862N variant, which showed reduced activity and decreased binding to the regulatory proteins 14-3-3. Collectively, our study provides a comprehensive herpesvirus-host interface resource, which aids our understanding of disease-associated molecular perturbations and data-driven identification of antiviral treatment options. - Source: PubMed
Publication date: 2025/07/30
Girault VirginieStukalov AlexeyCarter-Timofte Madalina ElenaHertzog JonnyVerin MelissaAusten KatharinaHaas Darya AOubraham LilaPiras AntonioMaidl SusanneÖllinger RupertRad RolandProtzer UlrikeKaufer Benedikt BLebbink Robert JRehwinkel JanMogensen Trine HPichlmair Andreas
Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles.
Different types of skeletal myofibers exhibit distinct physiological and metabolic properties that are associated with meat quality traits in livestock. Alternative splicing (AS) of pre-mRNA can generate multiple transcripts from an individual gene by differential selection of splice sites. N6-methyladenosine (m6A) is the most abundant modification in mRNAs, but its regulation for AS in different muscles remains unknown. RESULTS: We characterized AS events and m6A methylation pattern in pig oxidative and glycolytic muscles. A tota1 of 1294 differential AS events were identified, and differentially spliced genes were significantly enriched in processes related to different phenotypes between oxidative and glycolytic muscles. We constructed the regulatory network between splicing factors and corresponding differential AS events and identified NOVA1 and KHDRBS2 as key splicing factors. AS event was enriched in m6A-modified genes, and the methylation level was positively correlated with the number of AS events in genes. The dynamic change in m6A enrichment was associated with 115 differentially skipping exon (SE-DAS) events within 92 genes involving in various processes, including muscle contraction and myofibril assembly. We obtained 23.4% SE-DAS events (27/115) regulated by METTL3-meditaed m6A and experimentally validated the aberrant splicing of ZNF280D, PHE4DIP, and NEB. The inhibition of m6A methyltransferase METTL3 could induce the conversion of oxidative fiber to glycolytic fiber in PSCs. - Source: PubMed
Publication date: 2022/12/06
Tan BaohuaZeng JiekangMeng FanmingWang ShanshanXiao LiyaoZhao XinmingHong LinjunZheng EnqinWu ZhenfangLi ZicongGu Ting
The plasma peptides of sepsis.
A practical strategy to discover sepsis specific proteins may be to compare the plasma peptides and proteins from patients in the intensive care unit with and without sepsis. The aim was to discover proteins and/or peptides that show greater observation frequency and/or precursor intensity in sepsis. The endogenous tryptic peptides of ICU-Sepsis were compared to ICU Control, ovarian cancer, breast cancer, female normal, sepsis, heart attack, Alzheimer's and multiple sclerosis along with their institution-matched controls, female normals and normal samples collected directly onto ice. - Source: PubMed
Publication date: 2020/07/02
Thavarajah ThanusiDos Santos Claudia CSlutsky Arthur SMarshall John CBowden PeteRomaschin AlexanderMarshall John G
Genome-Wide Association Studies Associated with Backfat Thickness in Landrace and Yorkshire Pigs.
Although pork quality traits are important commercially, genome-wide association studies (GWASs) have not well considered Landrace and Yorkshire pigs worldwide. Landrace and Yorkshire pigs are important pork-providing breeds. Although quantitative trait loci of pigs are well-developed, significant genes in GWASs of pigs in Korea must be studied. Through a GWAS using the PLINK program, study of the significant genes in Korean pigs was performed. We conducted a GWAS and surveyed the gene ontology (GO) terms associated with the backfat thickness (BF) trait of these pigs. We included the breed information (Yorkshire and Landrace pigs) as a covariate. The significant genes after false discovery rate (＜0.01) correction were AFG1L, SCAI, RIMS1, and SPDEF. The major GO terms for the top 5% of genes were related to neuronal genes, cell morphogenesis and actin cytoskeleton organization. The neuronal genes were previously reported as being associated with backfat thickness. However, the genes in our results were novel, and they included ZNF280D, BAIAP2, LRTM2, GABRA5, PCDH15, HERC1, DTNBP1, SLIT2, TRAPPC9, NGFR, APBB2, RBPJ, and ABL2. These novel genes might have roles in important cellular and physiological functions related to BF accumulation. The genes related to cell morphogenesis were NOX4, MKLN1, ZNF280D, BAIAP2, DNAAF1, LRTM2, PCDH15, NGFR, RBPJ, MYH9, APBB2, DTNBP1, TRIM62, and SLIT2. The genes that belonged to actin cytoskeleton organization were MKLN1, BAIAP2, PCDH15, BCAS3, MYH9, DTNBP1, ABL2, ADD2, and SLIT2. - Source: PubMed
Publication date: 2018/09/30
Lee Young-SupShin Donghyun

ZNF280D may function as a transcription factor.

Related genes to: ZNF280D may function as a transcription factor.

Related products to: ZNF280D may function as a transcription factor.

Related articles to: ZNF280D may function as a transcription factor.

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Tianhua mutton sheep.

Multi-proteomic profiling of the varicella-zoster virus-host interface reveals host susceptibilities to severe infection.

Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles.

The plasma peptides of sepsis.

Genome-Wide Association Studies Associated with Backfat Thickness in Landrace and Yorkshire Pigs.