The function of SCML1 remains unknown.
- Known as:
- The function SCML1 remains unknown.
- Catalog number:
- 25-287
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- The function SCML1 remains unknown.
Related genes to: The function of SCML1 remains unknown.
- Gene:
- SCML1 NIH gene
- Name:
- Scm polycomb group protein like 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xp22.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-05
- Date modifiied:
- 2017-07-18
Related products to: The function of SCML1 remains unknown.
150 kDa cofactor of initiator function,CIF150,Homo sapiens,Human,RNA polymerase II TBP-associated factor subunit B,TAF(II)150,TAF2,TAF2B,TAFII150,TAFII-150,TBP-associated factor 150 kDa,Transcription17-AAG(Geldanamycin) 17-AAG is a less toxic analogue of the geldanamycin which binds to Hsp90 and alters its function. For research use only.6-Epi Doxycycline, 65% (Contains Unknown Salts) C22H24N2O8 CAS: 3219-99-66-Epi Doxycycline, 65% (Contains Unknown Salts) CAS: 3219-99-6 Formula: C22H24N2O8A single licensed Software Package for control functionA single licensed Software Package for control functionA single licensed Software Package for control function, including a RS 232 CableA single licensed Software Package for control function, including a RS 232 CableA1BG is a plasma glycoprotein of unknown function. It shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins.A1BG is a plasma glycoprotein of unknown function. It shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. The protein encoded by this gene is a pABHD13 is a single-pass type II membrane protein. It belongs to the serine esterase family. The exact function of ABHD13 remains unknown.Western blots using two different antibodies against two uniqueABHD13 is a single-pass type II membrane protein. It belongs to the serine esterase family. The exact function of ABHD13 remains unknown.Western blots using two different antibodies against two uniqueABHD13 is a single-pass type II membrane protein. It belongs to the serine esterase family. The exact function of ABHD13 remains unknown.Western blots using two different antibodies against two uniqueACTH ELISA, Pituitary and Adrenal Cortical FunctionActivated Goalpha interacted directly with PLZF, and enhanced its function as a transcriptional and cell growth suppressor. Goalpha might play a role in mediating extracellular signal-regulated kinase Related articles to: The function of SCML1 remains unknown.
- BACKGROUND: Acute myocardial infarction (AMI) is a critical and fatal cardiovascular condition. The role of cuproptosis as an emerging mechanism in the pathogenesis of AMI remains to be fully elucidated. METHODS: Patient data were acquired from the Gene Expression Omnibus database. Differential expression analysis was performed on cuproptosis-related genes (CRGs). LASSO regression was employed to identify key CRGs and develop a diagnostic classification model for AMI. Weighted gene co-expression network analysis was performed to investigate key modules associated with the disease and its molecular classification. Subsequently, machine learning techniques were used to identify critical genes within these modules. The diagnostic efficacy of these genes for AMI was assessed using receiver operating characteristic analysis. The functions of the identified key genes were ultimately validated at the cellular level. RESULTS: Six characteristic CRGs were selected via LASSO regression. The AMI diagnostic classification model based on these CRGs demonstrated superior performance. Patients were classified into two subtypes related to cuproptosis, revealing significant differences in enrichment pathways between these subtypes. SYTL3, SCML1, and PMAIP1 were identified as key genes for AMI, with area under the curves of 0.813, 0.795, and 0.873, respectively. Knocking down PMAIP1 expression reduced intracellular copper levels in hypoxia-induced HUVECs. CONCLUSIONS: This study clarifies the role of cuproptosis in AMI and highlights the potential involvement of PMAIP1, providing a theoretical basis for further investigation into cuproptosis in AMI. - Source: PubMed
Publication date: 2026/03/19
Wang JieChen XueyingWang HuabinFeng WenjingLin NanRen XueyunWang ManmanGan Lijun - Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of this connection remains unclear. The aim of this study was to explore further links between circadian rhythm and PCOS and to identify potential mediators of the pathogenesis of PCOS. - Source: PubMed
Publication date: 2025/05/22
Li WenjiaZhang GuanmeiFang YueWu SiyiSong XiaoboZhou LushanLei LeiWang ChenyeDing CaifeiWang Yixuan - This study aims to investigate the mechanisms underlying the role of chromatin regulator-related genes (CRRGs) in coronary artery disease (CAD) and develop a diagnostic model for CAD. - Source: PubMed
Zhao MeiLi WanyingPeng SiminMa XiaocongWang DingZheng Jinghui - Relevant studies have pointed out that Passiflora could relieve depressive disorder (DD) related symptoms, such as anxiety and insomnia, but its mechanism in DD has not been reported. In this study, DD-related transcriptome data was extracted from the Gene Expression Omnibus (GEO) database. Subsequently, 50 differentially expressed genes (DEGs) were screened by "limma," and the enrichment analysis of these DEGs revealed that they were associated with neuro-inflammatory-related signaling pathways, including IL-17, TNF, NF-kappa B, etc signaling pathways. Then, CCDC58, CXCL5, EGR1, LOC101929855, SCML1, and THBS1 were screened as biomarkers of DD by the least absolute shrinkage and selection operator (LASSO) analysis. Moreover, Harmaline, Harmine, Quercetin, and Kaempferol were the key chemically active ingredients of Passiflora. Noticeable, THBS1 and Quercetin were connected closely. In addition, the quantitative real-time polymerase chain reaction (qRT-PCR) confirmed that the key biomarkers (EGR1 and THBS1) were significantly lowly expressed in DD samples. In summary, we identified 2 key biomarkers of DD and 4 key chemically active ingredients of Passiflora. The potential mechanism of antidepressant effect of DD associated with neuro-inflammatory responses and neurotransmitter function. These might related to the synergistic activity of its key active ingredients with TNF-α, IL-1β, IL-6, etc, which work with EGR1 and THBS1 to regulate IL-17, NF-kappa B, TNF, etc signaling pathways. These findings might help to deepen the understanding of the mechanism of Passiflora in clinical treatment of DD. - Source: PubMed
Wang WeiZhai Gao-QiangXin MingLi JunLiao Jun-JuanLiang JiaLi Chang-Bao - Proper regulation of heterochromatin is critical for spermatogenesis. This study reveals the dynamic localization patterns of distinct chromatin regulators during spermatogenesis and disrupted sex chromatin status in spermatocytes in the absence of DICER. - Source: PubMed
Publication date: 2022/12/02
Prakash Yadav RamLeskinen SiniMa LinMäkelä Juho-AnttiKotaja Noora