FUBP1 is a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-
- Known as:
- FUBP1 a ssDNA binding protein activates far upstream element (FUSE) c-myc stimulates expression c-myc undifferentiated cells. Regulation FUSE FUBP occurs single-
- Catalog number:
- 25-281
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- FUBP1 ssDNA binding protein that activates the far upstream element (FUSE) c-myc and stimulates expression undifferentiated cells. Regulation FUSE FUBP occurs through single-
Related genes to: FUBP1 is a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-
- Gene:
- FUBP1 NIH gene
- Name:
- far upstream element binding protein 1
- Previous symbol:
- FUBP
- Synonyms:
- FBP
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-06
- Date modifiied:
- 2019-04-23
- Gene:
- FUSE NIH gene
- Name:
- polykaryocytosis promoter
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10
- Locus Type:
- phenotype only
- Date approved:
- 2001-06-22
- Date modifiied:
- 2012-10-02
- Gene:
- KHSRP NIH gene
- Name:
- KH-type splicing regulatory protein
- Previous symbol:
- -
- Synonyms:
- KSRP, FBP2, FUBP2
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-17
- Date modifiied:
- 2014-11-19
Related products to: FUBP1 is a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-
Related articles to: FUBP1 is a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-
- The three far-upstream element (FUSE) binding protein (FBP) family members have been ascribed different functions in gene regulation. They were therefore examined with various biochemical, molecular biological, and cell biological tests to evaluate whether their sequence differences reflect functional customization or neutral changes at unselected residues. Each FBP displayed a characteristic profile of intrinsic transcription activation and repression, binding with protein partners, and subcellular trafficking. Although some differences, such as weakened FBP3 nuclear localization, were predictable from primary sequence differences, the unexpected failure of FBP3 to bind the FBP-interacting repressor (FIR) was traced to seemingly conservative substitutions within a small patch of an N-terminal alpha-helix. The transactivation strength and the FIR-binding strength of the FBPs were in the opposite order. Despite their distinguishing features and differential activities, the FBPs traffic to shared subnuclear sites and regulate many common target genes, including c-myc. Though a variety of functions have been attributed to the FBPs, based upon their panel of shared and unique features, we propose that they constitute a molecular regulatory kit that tunes the expression of shared targets through a common mechanism. - Source: PubMed
Chung Hye-JungLiu JuhongDundr MiroslavNie ZuqinSanford SuzanneLevens David