CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind
- Known as:
- CHRNA4 a nicotinic acetylcholine receptor, belongs a supergroup ligand-gated ion channels play a role fast signal transmission synapses. pentameric receptors bind
- Catalog number:
- 25-237
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- CHRNA4 nicotinic acetylcholine receptor which belongs superfamily ligand-gated ion channels that play role fast signal transmission synapses. These pentameric receptors can bind
Related genes to: CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind
- Gene:
- CHRNA4 NIH gene
- Name:
- cholinergic receptor nicotinic alpha 4 subunit
- Previous symbol:
- EBN, EBN1
- Synonyms:
- BFNC
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-11
- Date modifiied:
- 2016-02-04
- Gene:
- DTNBP1 NIH gene
- Name:
- dystrobrevin binding protein 1
- Previous symbol:
- -
- Synonyms:
- Dysbindin, My031, HPS7, DBND, BLOC1S8
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-15
- Date modifiied:
- 2019-04-23
Related products to: CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind
Related articles to: CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind
- General intelligence (g) and virtually all other behavioral traits are heritable. Associations between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes involved in brain function have been reported. We sought to replicate published associations between g and 12 specific genetic variants (in the genes DTNBP1, CTSD, DRD2, ANKK1, CHRM2, SSADH, COMT, BDNF, CHRNA4, DISC1, APOE, and SNAP25) using data sets from three independent, well-characterized longitudinal studies with samples of 5,571, 1,759, and 2,441 individuals. Of 32 independent tests across all three data sets, only 1 was nominally significant. By contrast, power analyses showed that we should have expected 10 to 15 significant associations, given reasonable assumptions for genotype effect sizes. For positive controls, we confirmed accepted genetic associations for Alzheimer's disease and body mass index, and we used SNP-based calculations of genetic relatedness to replicate previous estimates that about half of the variance in g is accounted for by common genetic variation among individuals. We conclude that the molecular genetics of psychology and social science requires approaches that go beyond the examination of candidate genes. - Source: PubMed
Publication date: 2012/09/24
Chabris Christopher FHebert Benjamin MBenjamin Daniel JBeauchamp JonathanCesarini Davidvan der Loos MatthijsJohannesson MagnusMagnusson Patrik K ELichtenstein PaulAtwood Craig SFreese JeremyHauser Taissa SHauser Robert MChristakis NicholasLaibson David