MCG10 Antibody
- Known as:
- MCG10 Antibody
- Catalog number:
- 2479
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- MCG10 Antibody
Related genes to: MCG10 Antibody
- Gene:
- PCBP4 NIH gene
- Name:
- poly(rC) binding protein 4
- Previous symbol:
- -
- Synonyms:
- MCG10, LIP4
- Chromosome:
- 3p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-08-31
- Date modifiied:
- 2016-10-05
Related products to: MCG10 Antibody
Related articles to: MCG10 Antibody
- Diabetic retinopathy affects a substantial proportion of individuals with diabetes and, if not treated, may lead to acquired visual impairment or even blindness. An improved comprehension of the genetics of diabetic retinopathy (DR) is crucial in understanding the disease mechanisms. We aimed to identify rare and low-frequency variants predisposing to severe DR (SDR) in type 1 diabetes. - Source: PubMed
Vuori NadjaAntikainen Anni AHaukka Jani KHarjutsalo ValmaGroop Per-HenrikSandholm Niina - Accelerated eosinophilic apoptosis is an important therapeutic strategy for bronchial asthma (BA). - Source: PubMed
Publication date: 2025/07/09
Zhang JingyiWang MengqiYu DongxiaoQu ChangjieZhang JialinLao Huimin - Radiation-induced bystander effects are induced changes in cells that were not themselves directly irradiated but were in the vicinity of a radiation path. Such effects, which occur in the microenvironment of an irradiated tumor, remain poorly understood and depend on the cell type and irradiation quality. This study aimed to evaluate bystander effects in non-irradiated chondrocytes that received conditioned medium from irradiated chondrosarcoma cells. - Source: PubMed
Gilbert AntoinePayet ValentinBernay BenoîtChartier-Garcia ElisabethTestard IsabelleCandéias Serge MChevalier François - The biological roles and clinical significance of RNA-binding proteins (RBPs) in oral squamous cell carcinoma (OSCC) are not fully understood. We investigated the prognostic value of RBPs in OSCC using several bioinformatic strategies. - Source: PubMed
Publication date: 2021/07/30
Lu YingjuanYan YongcongLi BowenLiu MoLiang YancanYe YushanCheng WeiqiLi JinsongJiao JiuyangChang Shaohai - PCBP1, a member of the poly(C)-binding protein (PCBP) family, has the capability of binding heavily oxidized RNA and therefore participates in the cellular response to oxidative conditions, helping to induce apoptosis. There are four other members of this family, PCBP2, PCBP3, PCBP4, and hnRNPK, but it is not known whether they play similar roles. To learn more, we first tested their affinity for an RNA strand carrying two 8-oxoguanine (8-oxoG) residues at sites located in close proximity to each other, representative of a heavily oxidized strand or RNA with one 8-oxoG or none. Among them, only PCBP2 exhibited highly selective binding to RNA carrying two 8-oxoG residues similar to that observed with PCBP1. In contrast, PCBP3, PCBP4, and hnRNPK bound RNA with or without 8-oxoG modifications and exhibited slightly increased binding to the former. Mutations in conserved RNA-binding domains of PCBP2 disrupted the specific interaction with heavily oxidized RNA. We next tested PCBP2 activity in cells. Compared with WT HeLa S3 cells, PCBP2-KO cells established by gene editing exhibited increased apoptosis with increased caspase-3 activity and PARP1 cleavage under oxidative conditions, which were suppressed by the expression of WT PCBP2 but not one of the mutants lacking binding activity. In contrast, PCBP1-KO cells exhibited reduced apoptosis with much less caspase-3 activity and PARP cleavage than WT cells. Our results indicate that PCBP2 as well as PCBP1 bind heavily oxidized RNA; however, the former may counteract PCBP1 to suppress apoptosis under oxidative conditions. - Source: PubMed
Publication date: 2020/07/09
Ishii TakashiIgawa TatsuhiroHayakawa HiroshiFujita TsugumiSekiguchi MutsuoNakabeppu Yusaku