IL-21 Antibody
- Known as:
- Interleukin-21 Antibody
- Catalog number:
- 2465
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- IL-21 Antibody
Related genes to: IL-21 Antibody
- Gene:
- IL21 NIH gene
- Name:
- interleukin 21
- Previous symbol:
- -
- Synonyms:
- Za11, IL-21
- Chromosome:
- 4q27
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-29
- Date modifiied:
- 2019-04-23
Related products to: IL-21 Antibody
Related articles to: IL-21 Antibody
- It is thought that systemic sclerosis (SSc) might be a T helper 17 (Th17) cell-driven autoimmune disease. Noticeably, pulmonary arterial hypertension (PAH) is a leading cause of death in patients with SSc. Here, we investigated the association between serum Th17-related cytokines and prevalence of PAH in SSc patients. - Source: PubMed
Publication date: 2024/02/13
Seki NoriyasuTsujimoto HidetoTanemura ShuheiIshigaki ShoTakei HiroshiSugahara KunioYoshimoto KeikoAkiyama MitsuhiroKaneko YukoChiba KenjiTakeuchi Tsutomu - Dry eye disease (DED) features the inflammatory response of the ocular surface. Pro-inflammatory T helper 17 (Th17) cells are important for the pathogenesis of DED. In the present study a mouse DED model was used to discover two Th17 subsets in draining lymph nodes and conjunctivae based on the expression of IL-17 receptor E (IL-17RE) and CCR10: IL-17RECCR10 Th17 and IL-17RECCR10 Th17. IL-17RECCR10 Th17 expressed more retinoic acid-related orphan receptor gamma t but fewer T-box-expressed-in-T-cells than IL-17RECCR10 Th17. In addition, the former expressed higher IL-17A, IL-21, and IL-22 but fewer IFN-γ than the latter. Further analysis showed that IL-17RECCR10 Th17 did not express IFN-γ in vivo, whereas IL-17RECCR10 Th17 contained IFN-γ-expressing Th17/Th1 cells. Moreover, IL-17RECCR10 Th17 possessed more phosphorylated p38 mitogen-activated protein kinase (MAPK) and Jnk than IL-17RECCR10 Th17, suggesting higher activation of MAPK signaling in IL-17RECCR10 Th17. In vitro treatment with IL-17C effectively maintained IL-17A expression in Th17 cells through p38 MAPK rather than Jnk MAPK. Furthermore, the adoptive transfer of the two Th17 subpopulations indicated their equivalent pathogenicity in DED. Interestingly, IL-17RECCR10 Th17 cells were able to phenotypically polarize to IL-17RECCR10 Th17 cells in vivo. In conclusion, the current study revealed novel Th17 subsets with differential phenotypes, functions, and signaling status in DED, thus deepening the understanding of Th17 pathogenicity, and exhibited Th17 heterogeneity in DED. - Source: PubMed
Wang JunlingGong JinYang QingguoWang LinglinJian YanWang Ping - Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. This review introduces the roles of IL-17 and Th17 cells in human autoimmune diseases. Studies have shown that T cells with inflammatory effects on epithelial, endothelial and fibroblast cells express IL-17. Th17 cells are supposed to be involved in various autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Base on the biologic functions and regulation, IL-17 has regulatory roles in host defense and chronic inflammation which result in tissue damage and autoimmunity. So the IL-17 links links innate and adaptive immunity and has both beneficial and pathological effects on the immune system. This paper will focus on the possible roles of IL-17 in autoimmune diseases, a fundamental player in immune regulation. - Source: PubMed
Publication date: 2014/09/08
Shabgah Arezoo GowhariFattahi EbrahimShahneh Fatemeh Zare - About 60-80 % of chronic hepatitis B virus (HBV) carriers are characterized with persistently normal alanine transaminase (ALT). Differences of cytokine expression are associated with the prognosis of HBV infection. We investigated the expression pattern of 30 cytokines associated with anti-HBV immunity in patients with normal ALT. - Source: PubMed
Publication date: 2013/08/17
He DengmingLi MaoshiGuo ShiminZhu PengHuang HongfeiYan GuohuaWu QuanxinTao ShiqiTan ZhaoxiaWang Yuming