Aven Antibody
- Known as:
- Aven Antibody
- Catalog number:
- 2417
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- Aven Antibody
Related genes to: Aven Antibody
- Gene:
- AVEN NIH gene
- Name:
- apoptosis and caspase activation inhibitor
- Previous symbol:
- -
- Synonyms:
- PDCD12
- Chromosome:
- 15q14
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-17
- Date modifiied:
- 2016-10-05
Related products to: Aven Antibody
Related articles to: Aven Antibody
- The world is constantly changing, yet a risk assessment is based on the knowledge available at one point in time. There will therefore be a gap between the range of possibilities known or conceivable to the assessor at that time and all the possibilities that could occur over infinite time. This will leave the door open to surprises. Anticipating surprises, therefore, requires the narrowing of this knowledge gap. We outline an approach to narrowing it that transforms risk assessors' small-world representations into a large-world representation by configuring them into a small-world network. Small-world representations are individuals' partial and subjective perspectives on an aspect of reality. What we call a large-world representation integrates these small-world representations. This transformation narrows the knowledge gap by integrating dispersed knowledge about, and intersecting alternative framings of, a focal risk, thereby dynamically updating the knowledge landscape underpinning its assessment. We use the 9/11 attack as an example. That surprise resulted from a failure to intersect the frames "suicide attack" and "hijacking," meaning that the possibility of a "suicide hijacking" went unconsidered. Configuring risk assessors into a small-world network would have increased the chance that these two frames would intersect in a risk assessment, thereby anticipating this surprise outcome. In sum, the approach we outline operationalizes the recently extended (C, U) risk-assessment framework. It increases the chance that surprises are anticipated by enabling risk assessors to see as an integral whole what they could otherwise see only fragmentarily. - Source: PubMed
Derbyshire JamesAven Terje - To assess the real-world performance of the Serial Clinical Observation (SCO) strategy in identifying and treating Early-Onset Sepsis (EOS) cases, and to compare it with the recommendations the Neonatal Sepsis Calculator (NSC) would have provided. This multicentre study analyzed prospectively culture-confirmed EOS cases caused by Group B Streptococcus (GBS) or Escherichia coli (2016-2022) in term and late-preterm infants managed with the SCO approach in Italy. We evaluated the proportion of infants assigned to routine care at birth and the time to antibiotics. NSC scores at 4, 12, and 24 h after birth were retrospectively calculated. Of 57 EOS cases, 23 (40.4%) had no maternal risk factors. Fifty infants developed clinical signs of illness either at birth (n = 24) or postnatally (n = 26). Among those symptomatic at birth, the median time to antibiotic initiation was 2.0 h (IQR 1.0-5.75). "Major" clinical signs according to the SCO protocol were present in 79.2%, prompting immediate antibiotics. Retrospective NSC application at 4 h would have recommended antibiotics in 87.5%. Of the 26 who became symptomatic after birth, 16 (61.5%) were assigned to routine care. The median time from disease onset to treatment was 6.0 h (IQR 2.0-14.0). At 4 h, NSC would have assigned 19 (73.1%) of these infants to routine care. Subtle neurological signs (i.e. hypotonia, irritability, altered consciousness) were frequently observed at onset in infants who developed severe disease. - Source: PubMed
Publication date: 2026/04/16
Miselli FrancescaLugli LiciaDragone GiorgiaBedetti LucaSpinedi SofiaCapretti MariagraziaMarrozzini LuciaDi Luca LuisaFanaro SilviaGambini LuciaBiasucci GiacomoPiccinini GiancarloScarponi DavidePapa IreneNanni FrancescaBaroni LorenzaPagano RossellaCapone ValeriaBerardi Alberto - Powdery mildews from the genus infect economically significant crops such as strawberries ( ×) and raspberries (). Until recently, these powdery mildews have been assigned to , which represents a complex of species. In the present analysis, selected taxa within s. lat. have been subjected to morphological and ITS+28S rDNA phylogenetic examinations. We demonstrated that the powdery mildews on and spp. do not pertain to s. str. The new combination (≡ ) is introduced for the powdery mildew on ×, spp. and . is widespread in Asia and Europe, however, sequences obtained from specimens collected in South and North America belong to an unresolved group. All sequences obtained from specimens of powdery mildew on spp. group together in the phylogenetic tree. This suggests a separate species on spp. for which the new combination (≡ ) is introduced. sp. nov. is introduced for powdery mildews from western North America infecting and . Additionally, sp. nov. is introduced for powdery mildews in North America infecting spp. and . - Source: PubMed
Publication date: 2025/07/01
Bradshaw MichaelLiu MiaoCrouch UmaThomas JacklynShoukouhi ParivashJin Dan-NiLiu Shu-YanPaul AndrewBraun Uwe - Many individuals who initially present with depression later develop manic or hypomanic episodes, yet the biological processes accompanying this delayed shift remain unclear. Here, we examined whether perturbation of the adult hippocampal neurogenic niche is associated with time-dependent shifts in mood-relevant behaviors. Using Nestin-CreER::Rosa26-FloxedSTOP-DTa (Nestin-DTa) mice, we induced partial ablation of Nestin-positive adult neural stem cells (aNSCs) in the hippocampus by tamoxifen administration and assessed phenotypes at 4 and 8 weeks post-ablation. Neurogenic-lineage populations in the dentate gyrus were quantified by immunohistochemistry using stage-specific markers. Partial aNSC ablation reduced the Nestin-positive pool and BrdU-labeled proliferation, followed by a compensatory expansion of proliferative progenitors and DCX-positive neuroblasts. At 4 weeks, Nestin-DTa mice exhibited anxiety-like behavior and increased forced-swim immobility. By 8 weeks, anxiety-like measures normalized, and mice displayed increased exploratory/locomotor activity and reduced forced-swim immobility, accompanied by sustained elevation of progenitor and immature neuronal compartments. These findings provide a tractable model in which disruption of the adult neurogenic niche is associated with a transition from depression-like behavior to a hyperactive, mania-like phenotype over time. - Source: PubMed
Publication date: 2026/04/08
Song JieunKim WoonryongPark YoojinLee Ja-MyongKim Jong-HoonPark Dong-HyukLee Heon-JeongShin Ki-SoonKim Hyun JungGeum Dongho - Today, there is no authoritative accepted definition of safety science, although, empirically, delineations can be drawn based on the papers published in safety science journals. The meaning, object, and scope of safety science have been extensively discussed by leading scholars in recent years. The present paper aims to contribute to this discussion by clarifying safety science's foundation and relationship to risk science. The paper argues that there is a potential for further enhancement of the understanding, assessment, communication, and handling of safety issues by a stronger interaction with risk science, both generic and applied risk science. Safety science is concerned with topics which all relate to risk, yet we often see safety science literature on such topics without addressing risk. A main conclusion of the paper is that safety science can be included in risk science, with the main topics as part of applied risk science but also contributions to generic, fundamental risk science. - Source: PubMed
Aven Terje