APRIL Antibody

Price:

505.58 €

Known as:: APRIL Antibody
Catalog number:: 2223
Product Quantity:: 0.1 mg
Category:: -
Supplier:: Prosci
Gene target:: APRIL Antibody

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Related genes to: APRIL Antibody

Gene:: ANP32B ^{NIH gene}
Name:: acidic nuclear phosphoprotein 32 family member B
Previous symbol:: -
Synonyms:: SSP29, PHAPI2, APRIL
Chromosome:: 9q22.33
Locus Type:: gene with protein product
Date approved:: 2002-02-13
Date modifiied:: 2016-10-05

Gene:: TNFSF13 ^{NIH gene}
Name:: TNF superfamily member 13
Previous symbol:: -
Synonyms:: APRIL, CD256
Chromosome:: 17p13.1
Locus Type:: gene with protein product
Date approved:: 1998-12-04
Date modifiied:: 2017-03-02

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Related articles to: APRIL Antibody

APRIL promotes B-1 cell-associated neoplasm.
A tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe that 9- to 12-month-old APRIL transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B cell population. Aging APRIL transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer's patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into nonlymphoid tissues such as kidney and liver. We detected significantly increased APRIL levels in sera of B cell chronic lymphoid leukemia (B-CLL) patients, indicating that APRIL promotes onset of B-1-associated neoplasms and that APRIL antagonism may provide a therapeutic strategy to treat B-CLL patients. - Source: PubMed
Planelles LourdesCarvalho-Pinto Carla EHardenberg GijsSmaniotto SaletteSavino WilsonGómez-Caro RuthAlvarez-Mon Melchorde Jong JoanEldering EricMartínez-A CarlosMedema Jan PaulHahne Michael