Apaf1 Antibody
- Known as:
- Apaf1 Antibody
- Catalog number:
- 2013
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- Apaf1 Antibody
Related genes to: Apaf1 Antibody
- Gene:
- APAF1 NIH gene
- Name:
- apoptotic peptidase activating factor 1
- Previous symbol:
- -
- Synonyms:
- CED4, APAF-1
- Chromosome:
- 12q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-20
- Date modifiied:
- 2016-10-04
Related products to: Apaf1 Antibody
Related articles to: Apaf1 Antibody
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Publication date: 2026/04/09
Kumar DharmendraNancy Sharma Pramod Kumar - A20, encoded by tumor necrosis factor alpha-induced protein 3 (), is a key negative regulator of NF-κB signaling with context-dependent functions in cancer. Its role in renal cell carcinoma (RCC), particularly clear-cell RCC (ccRCC), remains incompletely defined. - Source: PubMed
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Jayab Nour AbuYener BurcuAlhamidi Reem SamiBhavsar MansiAltaie Alaa MuayadAlhammadi Muna AbdallaMohan Vidya BijoshAlmazrouei Marwa KhamisSahnoon LinaAbujabal RolaAl-Ramadi BaselBendardaf RiyadTalaat Iman MHamoudi Rifat - Efficient differentiation of pluripotent stem cells (PSCs) into functional cells is critical for regenerative medicine and biomanufacturing, yet is often hampered by apoptosis. Ginkgolide A (GA) is a diterpene lactone derived from Ginkgo biloba leaves and a member of the ginkgolide family, compounds known for diverse biological activities including neuroprotection and cardiovascular regulation. However, the mechanism by which ginkgolides influence the directed differentiation of stem cells remains unclear. Here, using a CRISPR-Cas9-engineered TNNT2-mCherry reporter PSC line and a defined cardiac differentiation protocol, we screened ginkgolides for their effects on cardiomyocyte production. Results demonstrated that GA significantly enhanced cardiomyocyte induction efficiency and accelerated the onset of spontaneous beating. Concurrently, GA effectively inhibited apoptosis during differentiation and RNA-seq results also revealed that GA orchestrates stage-specific upregulation of anti-apoptotic genes (e.g., MCL1, XIAP) and core cardiogenic transcription factors (NKX2-5, GATA4). Molecular docking predictions suggested a high binding potential between GA and cytochrome c, suggesting GA might inhibit the intrinsic mitochondrial apoptosis cascade by interfering with cytochrome c's binding to Apoptotic Peptidase Activating Factor-1 (APAF-1). These data demonstrate that GA enhances the differentiation of pluripotent stem cells into cardiomyocytes, potentially through its anti-apoptotic effect. This mechanism highlights its potential as a safe culture additive to boost cell survival and yield for large-scale biomanufacturing and tissue engineering applications. - Source: PubMed
Publication date: 2026/06/05
Xu WenjieWu XiaolongLei ZuoDang XiaoyuShi HongzhaoLi JiannanYuan LimingZhao YayaLi WenhaoChen JingLi NaHua Jinlian - Bread wheat (Triticum aestivum L.), among the earliest cultivated crops, provides approximately 20% of the overall protein and calorie intake in human diets. Considering its significance for global food and nutritional security, enhancing gene-based resources is essential for maintaining advancements in yield and quality in the future. Microsatellites or simple sequence repeats (SSRs) located within genes involved in important biological functions offer useful resources for developing gene-based markers. NB-ARC (nucleotide-binding adaptor shared by Apaf-1, R proteins, and CED-4) domain-containing genes, owing to their role in plant defense and stress responses, represent important targets for developing gene-based SSR markers. - Source: PubMed
Publication date: 2026/05/30
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Publication date: 2026/05/25
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