MS15 Tank (including electrodes)
- Known as:
- MS15 Tank (including electrodes)
- Catalog number:
- MS15TANK
- Category:
- -
- Supplier:
- Cleaver
- Gene target:
- MS15 Tank (including electrodes)
Related genes to: MS15 Tank (including electrodes)
- Gene:
- TANK NIH gene
- Name:
- TRAF family member associated NFKB activator
- Previous symbol:
- TRAF2
- Synonyms:
- I-TRAF
- Chromosome:
- 2q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-12
- Date modifiied:
- 2015-11-19
Related products to: MS15 Tank (including electrodes)
Related articles to: MS15 Tank (including electrodes)
- Understanding the evolutionary history of recent rapidly radiating groups remains a major challenge in systematics, especially when incomplete reproductive isolation and rampant interspecific gene flow obscure phylogenetic signal. Here, we present a comprehensive phylogenomic study of the genus ("the paintbrushes", Orobanchaceae), integrating nuclear and chloroplast data to investigate patterns of diversification, hybridization, and geographic structure across its range. Our results provide the first evidence that functions as a multicompartmentalized syngameon-a network of closely related species with ongoing or historical gene flow among non-sister lineages within and between geographically structured compartments. High nuclear gene tree discordance, coupled with strong cpDNA geographic compartment structuring and nuclear network analysis, supports the hypothesis that recent rapid radiation and Plio-Pleistocene climatic fluctuations created alternating periods of range expansion and contraction. These dynamics likely promoted localized hybridization within isolated compartments during contraction and further introgression between compartments during range expansion. Our findings not only clarify the evolutionary relationships within but also demonstrate the importance of genome-scale data and syngameon theory in understanding diversification in lineages where hybridization is rampant. - Source: PubMed
Publication date: 2026/09/10
Santos Malia AJacobs Sarah JLatvis MaribethHarrington SeanTank David C - We respond to the comments of Lin et al. on our Think Tank review of potential therapeutic avenues for idiopathic nocturia. - Source: PubMed
Publication date: 2026/10/01
Song Qi-XiangSinha SanjayVahabi BaharehKanai AnthonyFry ChristopherTyagi PradeepMusco StefaniaRobinson DudleyDrake Marcus JAbrams PaulWein AlanChapple Christopher R - The spread of unmanned aerial vehicles in daily operations makes the early and reliable diagnosis of propeller faults necessary. However, the performance values reported for such systems are usually obtained with sample level splits, and it is not known which feature representation should be matched with which learner. In this study, a leakage-free feature-model matching framework is presented for propeller fault classification. Microphone and six-axis inertial measurement unit data have been collected on a test bench with 980 kV and 1400 kV motors for one healthy and eight faulty propeller conditions at 16 throttle levels, and 8490 windows of 1 s have been extracted from 1735 measurement files. Four scalar feature sets and three time-frequency representations have been matched with seven ensemble learners and three compact convolutional networks under a file atomic split, and the permutation ranking of the best model has been returned to the feature selection stage. The highest macro-F1 value of 0.8027 and an accuracy of 0.8816 have been obtained with the stacked ensemble trained on the 52 input subset ranked by explainability. It is seen that the time domain statistics and the accelerometer axes are dominant, that three inertial axes reach a macro-F1 of 0.7661, and that cepstral and envelope features stay below the Welch-based features at the sampling rate of 90.9 Hz. The cross-motor experiments have shown that the models depend strongly on the motor class, and the McNemar test has confirmed that the difference between the ensemble branch and the compact convolutional branch is not accidental. In this way, the framework can be used as an evaluation protocol for low-cost multisensor setups on low-level devices. - Source: PubMed
Publication date: 2026/09/15
Seçkin Ahmet Çağdaş - Upper gastrointestinal cancer (UGC), including oesophageal and gastric cancers, imposes a substantial health burden, particularly in China. Timely treatment after a positive screening result is critical, as treatment delays may contribute to disease progression and poorer outcomes. This study aims to evaluate the effectiveness of a management model led by medical opinion leaders (MOLs) in shortening the time to treatment initiation among screen-positive patients with UGC. - Source: PubMed
Publication date: 2026/09/30
Liu RuyueZheng ChaoWang LiyuZhang NanSun Qiang - As a highly heterogeneous subtype of breast cancers, triple-negative breast cancer (TNBC) poses significant therapeutic challenges. This study aims to systematically investigate the activity and mechanism of action of a benzimidazole-based anion transporter (i.e., compound 1) in treating TNBC both in vivo and in vitro. The results showed that compound 1 markedly inhibited the proliferation of TNBC cells with high selectivity. Mechanistic studies demonstrated that compound 1 increased the levels of intracellular Cl and induced osmotic stress, mitochondrial dysfunction, and lysosomal alkalinization, leading to reactive oxygen species (ROS) accumulation, DNA damage, and reduced deoxyribonuclease II (DNase II) and cathepsin B (CTSB) levels. These alterations further activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-TANK-binding kinase 1 (TBK1)-interferon regulatory factor 3 (IRF3)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, promoted NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and gasdermin D (GSDMD) cleavage, and ultimately induced pyroptosis in MDA-MB-468 and 4T1 cells. In MDA-MB-468 and 4T1 breast cancer nude mouse models, compound 1 exhibited significant antitumor activity without obvious toxicity. In vivo analyses further confirmed the activation of pyroptosis-related signaling in tumor tissues. These results demonstrate that benzimidazole-based anion transporters drive inflammatory signaling and pyroptosis in TNBC cells. - Source: PubMed
Publication date: 2026/09/30
Chen LiYang HaodongHu JinhuiLi LanqingSun PinghuaChen Wen-Hua