MAb of mouse CD94
- Known as:
- MAb mouse CD94
- Catalog number:
- MA1-CD94
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Chimerigen
- Gene target:
- MAb mouse CD94
Related genes to: MAb of mouse CD94
- Gene:
- KLRD1 NIH gene
- Name:
- killer cell lectin like receptor D1
- Previous symbol:
- CD94
- Synonyms:
- -
- Chromosome:
- 12p13
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-16
- Date modifiied:
- 2016-01-14
Related products to: MAb of mouse CD94
Related articles to: MAb of mouse CD94
- Breast cancer is the most prevalent malignancy in women, and the limited effectiveness of current treatments highlights the need for novel immune regulatory mechanisms to improve long-term survival. This study investigated the role of Vim in PGI synthesis and its impact on tumor immune regulation. Multiomics profiling revealed molecular alterations following Vim deletion, which were validated in murine breast cancer models using RT-qPCR, Western blot, ELISA, and flow cytometry, with rescue experiments involving exogenous PGI. The findings showed that Vim deletion downregulated arachidonic acid metabolism, reduced PTGIS expression, and significantly lowered PGI levels. Functional assays demonstrated that Vim deficiency enhanced T cell-mediated antitumor immunity, evidenced by an increased proportion of CD8 T cells, upregulation of cytotoxic genes (, , , and ), and activation of inflammation-related signaling pathways, as indicated by enhanced phosphorylation of ERK1/2 and p65. Both exogenous PGI supplementation and ozagrel treatment reversed these effects. In conclusion, the Vim-PGI axis is identified as a key regulator of CD8 T cell immunity in breast cancer, representing a potential therapeutic target and a critical consideration in anticoagulant management during cancer immunotherapy. - Source: PubMed
Publication date: 2026/04/28
Quan HongShao LujingLi QiDong Chunyan - Meningococcal Serogroup A conjugate vaccine, as compared to the polysaccharide vaccine, has been clinically proven to induce superior protective immune responses against serogroup A infection in infants and young children. Studies examining the immune pathways/biomarkers responsible for the superiority of conjugate over plain polysaccharide vaccines are greatly required. This study reports the comparative whole blood transcriptomic profiles of the late-stage immune responses induced by meningococcal polysaccharide and conjugate vaccine in a murine model. Unique peripheral gene transcripts were induced by the Men A PS-tetanus toxoid (Men A PS-TT) vaccine compared to the Men A PS-alum (Men A PS-ALPO4) vaccine. Conjugate vaccine reported significant expression for Actb, Cd1d1, Klra8, Klrd1, Tnf, and H2-Q10 genes. Whereas plain polysaccharide vaccine reported key changes for Itga2b, H2-Ab-1, Cd8b1, and Icam2 genes. Annotation studies reported markers related to cytokine and chemokine activation, T and B cell activation, NKT-cell mediated cytotoxicity, antigen processing and presentation, and complement activation were differentially expressed in the conjugate vaccine as compared to the polysaccharide vaccine. The study reports late-stage immune markers that could be potential biomarkers for a better understanding of pathways responsible for immunity to T cell-dependent and independent antigens. - Source: PubMed
Publication date: 2026/04/04
Patel KrunalGautam ManishGairola Sunil - Antibody-mediated rejection (ABMR) in heart transplants is often negative for donor-specific antibody (DSA). We explored potential molecular differences between DSA-negative and DSA-positive molecular ABMR in 212 heart endomyocardial biopsies from the prospective Trifecta-Heart study (NCT04707872). - Source: PubMed
Publication date: 2026/03/13
Madill-Thomsen Katelynn SHidalgo Luis GMackova MartinaDemko ZachPrewett AdamCampbell PatrickFelius JoostGong TimothyHall ShelleyKim Daniel HKuczaj AgnieszkaLowe DaveMaliakkal NevilleMelenovsky VojtěchOlympios MichaelPatel SnehalPrzybylowski PiotrSayer GabrielTseliou EleniUriel NirStehlik JosefHalloran Philip F - The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. - Source: PubMed
Publication date: 2026/03/07
Dąbrowska IzabelaGrzędzicka-Agko JowitaKiełbik PaulaTrela MichałWitkowska-Piłaszewicz Olga - Natural killer (NK) cells expressing inhibitory receptors that recognize self human leukocyte antigen (HLA) class I molecules gain enhanced functionality-a process influenced by genetic polymorphism that dictates the strength of interactions between inhibitory receptors and their HLA ligands. Inhibitory CD94/NKG2A binds HLA-E loaded with epitopes derived from polymorphic HLA class I signal peptides (SPs). We generated a metric, called SP score, that quantifies the overall strength of CD94/NKG2A-HLA-E interactions based on a person's SP genotype. SP scores correlated positively with NKG2ACD56 NK cell response to HLA class I-negative cells, indicating that CD94/NKG2A-HLA-E interaction strength promotes NK cell education. Concordantly, higher SP scores associated with lower risk of nasopharyngeal carcinoma and ulcerative colitis. Thus, the SP score may serve as a genetic tool to guide clinical NK cell intervention strategies, including therapeutic NKG2A blockade. - Source: PubMed
Publication date: 2026/03/04
Lin ZhansongBashirova Arman ACallahan CianNelson George WRobinson EmmaViard MathiasTang MinzhongHildesheim AllanFranke AndreRioux John DGarcia-Beltran WilfredoCarrington Mary