Fluoro AChE
- Known as:
- Fluoro AChE
- Catalog number:
- AChE 100-2
- Product Quantity:
- 100 tests
- Category:
- -
- Supplier:
- Cell Technology
- Gene target:
- Fluoro AChE
Related genes to: Fluoro AChE
- Gene:
- ACHE NIH gene
- Name:
- acetylcholinesterase (Cartwright blood group)
- Previous symbol:
- YT
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-02
- Date modifiied:
- 2019-04-23
Related products to: Fluoro AChE
(+)-5-Fluoro-2'-deoxyuridine (+)-5-Fluoro-2'-deoxyuridine For research use only.(-)-β-D-Dioxolane-5-fluoro Cytidine C8H10FN3O4 CAS: 145397-26-8(-)-β-D-Dioxolane-5-fluoro Cytidine CAS: 145397-26-8 Formula: C8H10FN3O4(11β)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione C22H26ClFO3 CAS: 1356190-17-4(11β)-21-Chloro-9-fluoro-11-hydroxy-16-methylpregna-1,4,16-triene-3,20-dione CAS: 1356190-17-4 Formula: C22H26ClFO3(11β,16α)-21-(Acetyloxy)-9-fluoro-11,16,17-trihydroxy-pregna-1,4,14-triene-3,20-dione C23H27FO7 CAS: 131918-74-6(11β,16α)-21-(Acetyloxy)-9-fluoro-11,16,17-trihydroxy-pregna-1,4,14-triene-3,20-dione CAS: 131918-74-6 Formula: C23H27FO7(11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione-d2 3,20-Dioxime C21H27D2FN2O6 CAS:(11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione-d2 3,20-Dioxime CAS: Formula: C21H27D2FN2O6(11β,16α)-9-Fluoro-11,21,21-trihydroxy-16,17-[(1-methylethylidene)bis(oxy)]
pregna-1,4-diene-3,20-dione CAS: 161740-69-8 Formula: C24H31FO7(11β,16α)-9-Fluoro-16,17,21-trihydroxyl-pregna-1,4-diene-3,11,20-trione 3,20-Dioxime C21H27FN2O6 CAS:(11β,16α)-9-Fluoro-16,17,21-trihydroxyl-pregna-1,4-diene-3,11,20-trione 3,20-Dioxime CAS: Formula: C21H27FN2O6(11β,16α,20R)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid C22H29FO5 CAS: 50764-01-7(11β,16α,20R)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid CAS: 50764-01-7 Formula: C22H29FO5(11β,16α,20S)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid C22H29FO5 CAS: 50764-02-8 Related articles to: Fluoro AChE
- Trigeminal neuralgia (TN) is a debilitating neuropathic pain disorder characterized by sudden, intense facial pain, with diagnosis heavily reliant on subjective symptom reporting, leading to frequent misdiagnosis and treatment delays. This study aimed to develop and evaluate a proof-of-concept electroencephalography (EEG)-based automated detection framework for TN through systematic comparison of multiple classification architectures using multi-domain feature analysis. Resting-state EEG recordings were acquired from 72 subjects (36 TN patients: mean age 44 ± 13.98 years; 36 healthy controls: mean age 27.75 ± 3.15 years) using 19 scalp channels sampled at 250 Hz during 5 min eyes-closed sessions. Following standardized preprocessing, signals were decomposed into five frequency bands using discrete wavelet transform, and 40 quantitative features spanning temporal, spectral, complexity, statistical, and nonlinear domains were extracted per band, generating 3,800 initial features. A two-stage selection procedure identified 28 optimal features with high discriminative power (p < 0.05; |d|> 0.5 for 22 features) and low inter-feature correlation. Six architectures were evaluated through subject-wise fivefold stratified cross-validation: Support Vector Machine, Random Forest, Decision Tree, Deep Neural Network, Baseline Convolutional Neural Network, and a novel Convolutional Neural Network with Attention model employing 64 × 64 grayscale image transformation of multi-domain temporal features. Statistical analysis identified 1,877 significant feature-channel-band combinations, with the Gamma band (30-50 Hz) demonstrating the highest discriminative power (512 significant features; Cohen's d > 5.9 for frontal Approximate Entropy) and frontal regions showing predominant alterations (43.3% of significant features). Analysis of Covariance confirmed that 22 of 28 discriminative features (78.6%) retained significance independent of the inter-cohort age difference (ηp ≥ 0.06). Under subject-wise cross-validation, the CNN with Attention model achieved the highest preliminary performance, with 96.44 ± 2.60% accuracy, ROC-AUC of 0.996 ± 0.007, and recall of 99.8 ± 0.3%, outperforming Random Forest (92.30%), Baseline CNN (93.81%), Deep Neural Network (88.74%), Decision Tree (83.03%), and Support Vector Machine (62.96%). These metrics should be interpreted with caution, as the healthy control cohort comprised only 14 real independent subjects prior to augmentation; consequently, each test fold in the fivefold cross-validation was evaluated against 2-3 truly independent controls alongside their synthetic counterparts, which substantially constrains the generalizability of the reported figures. This study provides preliminary proof-of-concept evidence that EEG-based automated detection is a promising non-invasive approach for TN, with the CNN with Attention architecture demonstrating encouraging performance on a small, augmentation-dependent dataset. The identified neurophysiological signatures, particularly Gamma-band entropy alterations and frontal complexity measures, advance understanding of central nervous system reorganization in TN. However, the reported performance metrics are contingent on a limited number of truly independent controls and must not be interpreted as indicative of clinical readiness. External validation on large, independently acquired, age-matched cohorts is an essential prerequisite before any conclusions regarding diagnostic generalizability can be established. - Source: PubMed
Publication date: 2026/07/16
Samieirad SinaBoroujeni Sajjad RezvaniRokhva ShayanBehtaji SepehrAnousheh MiladAmiri Seyedeh RahemehNajafzadeh Hossein - Chronic pain and posttraumatic stress disorder (PTSD) have shared, often overlapping pathophysiology. Treatment options include complementary and integrative health (CIH) interventions, which have been summarized in numerous systematic reviews and meta-analyses (SR/MAs). - Source: PubMed
Publication date: 2026/07/16
Zaccari BelleLovejoy Travis ISomohano VanessaKaplan JoshuaPaynter Robin AKansagara DevanO'Neil Maya E - Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by pathological pulmonary vascular remodeling leading to right heart failure. Ralinepag extended-release (XR), is a once-daily oral prostacyclin (IP) receptor to treat PAH. This study evaluated the safety, tolerability, and pharmacokinetics (PK) of multiple ascending doses of ralinepag XR tablets in fed and fasted healthy adult volunteers. - Source: PubMed
Publication date: 2026/07/16
Lachant DanielBotta Cristian EGiannakoulas GeorgePatzlaff NatalieSeaman ScottBroderick MeredithGuido MariaMellemkjær SørenSafdar Zeenat - Distortions in time perception under pain have been widely reported, yet the mechanisms underlying these effects remain unclear. The Attentional Gate Model and prior empirical research indicate that attention and arousal are associated with pain and time perception, yet their roles remain unexamined in a unified framework. The study aimed to investigate the mediating roles of arousal, attention control, and attention bias in the relationship between pain and time perception. A systematic search of China National Knowledge Infrastructure, Wanfang, Web of Science, and PubMed identified studies reporting associations among pain, arousal, attention control, attention bias, and time perception. A two-stage meta-analytic structural equation modeling approach was used to test mediation, with multilevel meta-regression analyses examining moderation by age, gender, pain type, and target duration. A total of 154 articles (176 independent studies) were included. Pain was positively correlated with time perception, arousal, and attention bias. Both arousal and attention bias were positively correlated with time perception, while arousal was negatively correlated with attention control and attention bias. Mediation analysis showed that only arousal had a significant mediating effect. Moderation analysis indicated that age, gender, and target duration significantly moderated the relationships between attentional processes and time perception, with age additionally moderating the relationship between attention control and attention bias. Overall, arousal showed a mediating role between pain and time perception, while attentional effects are context-dependent. This study extends the Attentional Gate Model to pain and clarifies the roles of arousal and attentional mechanisms in temporal experience under pain. OPEN PRACTICES STATEMENT: This study was preregistered on the Open Science Framework ( https://osf.io/suzhn/ ). The data and code are publicly available online ( https://osf.io/3ucvb/ ). - Source: PubMed
Publication date: 2026/07/16
Xiao ChunhuaYin HuazhanWu Dehua - Postoperative rehabilitation utilizing the single-joint Hybrid Assistive Limb (HAL-SJ) following total knee arthroplasty (TKA) has been reported to facilitate early functional recovery. This study aimed to elucidate the firing properties of individual motor units (MU) during knee exercise post-TKA with HAL-SJ assistance. - Source: PubMed
Publication date: 2026/07/16
Watabe TakayaNishikawa YuichiNaito HisashiMuramatsu RyotaTaniguchi Yuta