Antibody CD79a _B lymphocytes JCB117
- Known as:
- Antibody CD79a _B lymphocytes JCB117
- Catalog number:
- AB01042
- Product Quantity:
- 3.0ml
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- Antibody CD79a _B lymphocytes JCB117
Related genes to: Antibody CD79a _B lymphocytes JCB117
- Gene:
- CD79A NIH gene
- Name:
- CD79a molecule
- Previous symbol:
- IGA
- Synonyms:
- MB-1
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-07-31
- Date modifiied:
- 2019-04-23
Related products to: Antibody CD79a _B lymphocytes JCB117
Related articles to: Antibody CD79a _B lymphocytes JCB117
- - Source: PubMed
Publication date: 2026/08/14
Yu ZacharyChen Han-HoLee Jen-ChiehLin Yun-ChuYuan Chang-Tsu - Multiple myeloma (MM) is a malignant plasma cell neoplasm, while extramedullary plasmacytoma (EMP) represents a rare manifestation and is frequently associated with an adverse prognosis. Gastric involvement by EMP is exceedingly uncommon and may present significant diagnostic challenges, particularly in cases with atypical immunophenotypic features that resemble B-cell lymphomas, most notably extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). - Source: PubMed
Publication date: 2026/06/26
Ngoc Dung NguyenThi Thuy Trang PhanThi Nguyet Anh PhiNhu Y LeQuang Tung NguyenVu Bao Anh Nguyen - Fluid overload-associated B-cell lymphoma (FO-LBCL) is a B-cell neoplasm that presents as serous effusions without detectable tumor masses and Kaposi sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8) infection. Here, we report a case of an 81-year-old female patient with FO-LBCL (Stage IVA) who presented with pericardial and pleural effusions. The patient had no underlying medical condition that could lead to fluid overload. Cytological examination of both effusions revealed medium- to large-sized lymphoid cells with high nucleocytoplasmic ratios, irregular nuclei, dense chromatin, prominent nucleoli, mitotic figures, basophilic cytoplasm, and lymphoglandular bodies. A cell block of the pleural fluid effusion showed that atypical lymphoid cells were positive for CD20 and CD79a, and negative for CD3, KSHV/HHV-8, and Epstein-Barr virus. The Ki-67 labeling index was 95%. The patient underwent systemic chemotherapy and achieved complete remission without pleural or pericardial recurrence during the 3-year follow-up period. As FO-LBCL is diagnosed based on cytological material, together with clinical and imaging findings, immunohistochemical analysis of the cell block is useful for confirming the diagnosis and selecting tailored therapies. - Source: PubMed
Publication date: 2026/08/11
Okanishi HiroyukiKuwabara HirokoNakayama HirokoOdaka MayoAriga KozueKataoka IsakoTomiuka MariUragami MayumiDeguchi ChihiroOno ShizukaTakeda ReikaKurisu YoshitakaHirose YoshinobuKinoshita YuukiYokote Taiji - Romanowsky-stained smears (RSSs) can be used to immunophenotype lymphoid neoplasms by immunocytochemistry (ICC). This technique typically involves incubating the antibodies separately. However, there is no description of a manual double-staining ICC (dsICC) to characterize lymphocytes in canine samples. This study aims to develop, optimize, and validate a dsICC assay for two lymphoid markers on canine RSSs. An initial antibody selection phase using four candidate markers for B-cells (CD20, CD21, PAX-5, CD79a) and two candidate markers for T-cells (CD3ε, CD5) was performed on unstained and RSSs. Further, CD20 and CD3ε were applied to RSSs for protocol development and optimization. Ultimately, the technique was applied to an independent set of 28 cytological preparations of canine lymphoid neoplasms for validation. The dsICC interpretation was compared with the immunophenotype provided by immunohistochemistry and/or flow cytometry, and/or to the genotype provided by PCR for antigen receptor rearrangement. The dsICC correctly immunophenotyped 26/28 samples (92.85%), including 19 B-cell lymphomas (19/20; 95%) and 7 T-cell lymphomas (7/8; 87.5%); the two inconclusive cases (7.14%) were one B-cell and one T-cell neoplasm. In most smears, the neoplastic B and T lymphocytes displayed a moderate to strong immunoreaction against CD20 and CD3ε, respectively. Residual non-neoplastic T and B-cells were also immunolabeled. The dsICC showed almost perfect agreement (κ = 0.84) compared to confirmatory results. This immunodiagnostic assay represents a potential alternative in veterinary oncology for canine lymphoma immunophenotyping; it enables diagnosis and immunophenotyping from a single smear and may be suitable for the development of an automated dsICC. - Source: PubMed
Publication date: 2026/08/06
Benaduce Emanuelli Mello Camilada Silva Serpa Priscila BeatrizPires Dos Santos AndreaMelazzo de Andrade Cinthia - Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a high-risk subtype of T-cell acute lymphoblastic leukemia (T-ALL). Aberrant CD19 expression in ETP-ALL may lead to misdiagnosis of mixed-phenotype acute leukemia. Notably, mutations, an established molecular hallmark of acute myeloid leukemia (AML), are extremely rare in T-ALL. - Source: PubMed
Publication date: 2026/07/22
Lu YanChen YiranZhang QiaohongWu Gongqiang