Sphingosine kinase 2
- Known as:
- Sphingosine phosphorylation catalyst 2
- Catalog number:
- 40611
- Product Quantity:
- 20 µg
- Category:
- -
- Supplier:
- BPS Bioscience
- Gene target:
- Sphingosine kinase 2
Related genes to: Sphingosine kinase 2
- Gene:
- ANKK1 NIH gene
- Name:
- ankyrin repeat and kinase domain containing 1
- Previous symbol:
- -
- Synonyms:
- X-kinase
- Chromosome:
- 11q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-13
- Date modifiied:
- 2013-01-10
Related products to: Sphingosine kinase 2
Related articles to: Sphingosine kinase 2
- Amantadine is the most commonly used pharmacologic treatment for levodopa-related dyskinesias (LRD), yet its efficacy and tolerability vary substantially, challenging clinical decision-making. - Source: PubMed
Publication date: 2026/10/01
Chaparro-Solano Henry MauricioSaadatpour LeilaYu Jeryl Ritzi TSonneborn ClairePeixoto-Leal ThiagoPiccinin Camila CAnis SaarKaur HarpreetAssaedi EkhlasMata Ignacio FFernandez Hubert H - Sexual dysfunction is a common comorbidity in patients with epilepsy; it correlates with seizure frequency and right temporal lobe epilepsy and affects quality of life (QOL). Despite its clinical significance, sexual dysfunction is often underassessed in clinical practice. Brivaracetam (BRV), an anti-seizure medication (ASM) introduced in recent years, is considered to have few psychiatric side effects, and no association with sexual dysfunction has been reported to date. We report a case of temporal lobe epilepsy in which the patient exhibited increased libido following the initiation of BRV. - Source: PubMed
Horinouchi ToruMatsuyama TaikiMito MayusaNakamura YuichiKato Takahiro A - Recent studies have linked modifiable risk factors (RFs) to melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). This study aimed to investigate the causal relationships between 11 modifiable RFs and these skin cancers and to identify novel therapeutic targets using multi-omics approaches. - Source: PubMed
Publication date: 2026/07/07
Qin ZhenHuoshen WudaLi XueqingLi ShiyuSun ChenYi Sha - Previous studies have demonstrated that exercise can influence motor skill learning. However, the specific components of learning primed by exercise remain unclear. This study examined the effect of a preceding bout of high intensity interval training (HIIT) on the acquisition of a novel motor skill. The investigation focused on whether improvement in skill across the session was attributable to online gains during active practice or offline rest periods between practice blocks. Whether common polymorphisms of the BDNF and DRD2/ANKK1 genes that regulate plasticity, learning, and memory, influenced the relationship between exercise and motor learning was also investigated. HIIT enhanced skill acquisition, but the effects of HIIT priming were not specifically attributable to within-session online or offline learning processes. Contrary to research on overnight consolidation, there was no interaction between BDNF, nor DRD2/ANKK1 genotype, with exercise primed skill learning. This builds our understanding of how exercise benefits skill leaning over a single session. - Source: PubMed
Publication date: 2026/06/26
Brooks EmilyHawi ZiarihHosler JulietKwee JessicaAljehany NerminByblow WinstonHendrikse JoshuaCoxon James - Alcohol use disorder (AUD) is influenced by genetic factors that affect key neurobiological systems, including dopaminergic and GABAergic pathways, which regulate neurobehavioral functions and are modulated by brain-derived neurotrophic factor (BDNF). Variations in these genes contribute to individual vulnerability to AUD. In this study, we investigated single-nucleotide polymorphisms (SNPs) and haplotypic associations in , , and , along with the dopaminergic pathway genes / and , in a Spanish cohort. Peripheral blood-derived genomic DNA was genotyped, and haplotype analyses were conducted. Individual SNPs in , , BDNF, and / showed no significant associations with AUD. In , the rs3219151 T allele was more frequent in AUD patients than in controls (57.9% vs. 49.3%; = 0.03), while the C allele appeared to show a potential protective association. In addition, the GAC haplotype of (rs2197414, rs1992647, rs3219151) was less frequent in AUD than in controls (0.071 vs. 0.122) and showed a protective association (OR = 0.58; 95% CI = 0.34-0.99; = 0.045). Our findings provide exploratory evidence suggesting that specific genetic variants and haplotypes may contribute to AUD susceptibility and support the relevance of multigenic and haplotypic approaches for exploring the neurobiological mechanisms underlying AUD. - Source: PubMed
Publication date: 2026/06/15
Rojas-Pirela MauraGómez Lesmes Sandra PatriciaSalete-Granado DanielLlorente HernánPérez Nieto María-ÁngelesNovo-Veleiro IgnacioCieza-Borrella ClaraPastor IsabelFernández-Mateos JavierInés Revuelta Sandra MChamorro Antonio-JavierLaso Francisco-JavierGonzález-Sarmiento RogelioMarcos Miguel