c-Myc Peptide -
- Known as:
- c-Myc Peptide -
- Catalog number:
- 06-271-83163
- Product Quantity:
- 1 mg
- Category:
- -
- Supplier:
- GenWay
- Gene target:
- c-Myc Peptide -
Related products to: c-Myc Peptide -
Related articles to: c-Myc Peptide -
- High-grade B-cell lymphoma, not otherwise specified (HGBCL, NOS), is defined by morphologic features intermediate between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL). Lymphomas with a complex 11q aberration or concurrent MYC- and BCL2- or BCL6-rearrangements are excluded from this category. However, the reproducibility of the diagnosis of HGBCL, NOS is unknown to date. Expert hematopathologists of the Lymphoma/Leukemia Molecular Profiling Project reviewed 92 cases submitted as HGBCL, NOS. At least 3/4 hematopathologists reviewing cases independently confirmed the diagnosis in 30/92 (33%) cases, while 13 cases (14%) were reclassified as DLBCL. The remaining 49 cases were jointly reviewed by the consensus panel of 10 to 15 pathologists, confirming an additional 9 HGBCL, NOS. The remaining cases were reclassified as DLBCL or other aggressive B-cell lymphomas or were excluded due to insufficient material. In aggregate, only 39/92 (42%) of initially submitted cases were confirmed as HGBCL, NOS, demonstrating poor interobserver agreement. Interestingly, however, there were no significant differences between the initially submitted cohort and those ultimately confirmed by the pathology review panel concerning dark zone signature (DZsig) expression, frequency of MYC-rearrangements and cell of origin, among others. Despite the finding that pathologists can identify cytomorphological features associated with adverse biological characteristics, the poor reproducibility of high-grade morphology and molecular heterogeneity suggests that HGBCL, NOS does not represent a distinct clinicopathologic entity and that more objective markers of distinct biologic features, such as the DZsig, may better separate cases into relevant diagnostic categories than morphology alone. - Source: PubMed
Publication date: 2026/05/11
Kurz Katrin SOndrejka Sarah LCollinge BrettSlack Graham WFarinha PedroRosenwald AndreasCampo EliasAmador CatalinaGreiner Timothy CRaess Philipp WSong Joo YJaffe Elaine SWeisenburger Dennis DChan Wing CBeiske KlausFu KaiDelabie JanPittaluga StefaniaFeldman Andrew LRimsza Lisa MScott David WOtt GermanCook James R - Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor clinical outcomes, highlighting the need for enhanced understanding of its molecular drivers. The present study investigated the functional role of long non-coding RNA LINC00184 in ESCC progression. Using overexpression experiments in KYSE-150 and TE-1 cell lines, the present study demonstrated that LINC00184 significantly enhances ESCC cell proliferation and migration while inhibiting apoptosis. Mechanistic studies revealed that LINC00184 recruits DNA methyltransferase 1 (DNMT1) to the promoter of the tumor suppressor gene N-Myc downstream regulated gene 2 (NDRG2), thereby catalyzing CpG island hypermethylation and transcriptional silencing of NDRG2. The subsequent downregulation of NDRG2 results in activation of the oncogenic PI3K/AKT signaling pathway. Notably, treatment with the DNMT1 inhibitor 5-azacytidine reverses LINC00184-induced NDRG2 promoter methylation, restores NDRG2 expression and attenuates PI3K/AKT pathway activation. The present study findings identified a novel LINC00184/DNMT1/NDRG2/PI3K-AKT regulatory axis in ESCC and suggested that targeting this epigenetic pathway may represent a promising therapeutic strategy in the future. - Source: PubMed
Publication date: 2026/04/28
Guo JunjunFu ShenboLiu JiaLi LinaZhao JinWang FenggangWu WenanChen XuLi Enxiao - Schott is a traditional medicinal plant valued for its mosquito-repellent properties, which are attributed to its terpenoid constituents. HS-SPME-GC-MS analysis of different tissues and developmental stages revealed a complex volatile profile, with multiple terpenoids detected in the samples. Genome-wide characterization of the terpene synthase (TPS) family revealed that the TPS-a subfamily forms a gene cluster on chromosome 6, likely resulting from tandem duplication events followed by relaxed selection pressure in tandem repeat regions. Functional assays showed that only and exhibit sesquiterpene synthase activity. Under HS-SPME-GC-MS conditions, AtsTPS8 produced germacrene B (which is detected as -elemene), whereas AtsTPS2 produced germacrene A (which is detected as -elemene), these detected signals were interpreted as products of heat-induced rearrangement during analysis. was selected for further study. Site-directed mutagenesis identified Lys461 as a critical residue regulating catalytic efficiency; compared with the wild type, the K461A mutant increased the yield of the detected product by 145%. Transient overexpression of AtsTPS2 in led to a 2.02-fold increase in the abundance of the detected product peak, and increased mosquito repellency to 83%. Furthermore, the MYC family transcription factor AtsMYC5 was found to repress expression by directly binding to its promoter. This study identifies AtsTPS2 as a sesquiterpene synthase in , clarifies its catalytic properties and AtsMYC5-mediated transcriptional regulation, and suggests that the corresponding sesquiterpene pathway contributes to mosquito repellency in this species. - Source: PubMed
Publication date: 2026/04/29
Peng FayuanChu JinBai XiaofenWang BoLi JieSun XuLiu LinFan Honghong - - Source: PubMed
Thomas-Tikhonenko AndreiViard-Leveugle IsabelleDews MichaelWehrli PhilippeSevignani CinziaYu DuonanRicci StaceyEl-Deiry WafikAronow BruceKaya GürkanSaurat Jean-HilaireFrench Lars E - - Source: PubMed
Dews MichaelFox Jamie LHultine StacySundaram PremaWang WengeLiu Yingqiu YFurth EmmaEnders Gregory HEl-Deiry WafikSchelter Janell MCleary Michele AThomas-Tikhonenko Andrei