GCR_RAT Nr3c1 ELISA tesk kit
- Known as:
- GCR_RAT Nr3c1 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen17372
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- GCR_RAT Nr3c1 ELISA tesk kit
Related genes to: GCR_RAT Nr3c1 ELISA tesk kit
- Gene:
- NR3C1 NIH gene
- Name:
- nuclear receptor subfamily 3 group C member 1
- Previous symbol:
- GRL
- Synonyms:
- GR
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
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- Early life stress (ELS) is a critical environmental factor influencing developmental trajectories of behavioral and emotional regulation. Increasing evidence suggests that such experiences can alter biological systems during sensitive developmental periods through epigenetic processes. This systematic review aims to synthesize empirical human studies examining how ELS contributes to the developmental programming of mental health via epigenetic regulation of stress-response systems. This systematic review was conducted in accordance with PRISMA 2020 guidelines. A comprehensive search of PubMed/MEDLINE, Web of Science, Scopus, and PsycINFO databases was performed for studies published up to March 2026. Eligible studies included empirical human research investigating associations between ELS, epigenetic mechanisms (primarily DNA methylation), and mental health-related outcomes across developmental stages. A total of 14 studies met inclusion criteria and were synthesized using a qualitative approach. Findings indicate that ELS is associated with persistent epigenetic modifications in key genes regulating stress-response systems, particularly within the hypothalamic-pituitary-adrenal (HPA) axis. Altered DNA methylation patterns in genes such as NR3C1, FKBP5, SLC6A4, MAOA, and ANK3 were consistently linked to developmental alterations in emotional regulation and increased vulnerability to psychiatric conditions, including depression, anxiety disorders, and post-traumatic stress disorder. Importantly, evidence highlights early childhood as a sensitive developmental window during which environmental inputs exert stronger and more enduring biological effects. Some studies further suggest that epigenetic profiles may show partial plasticity in response to environmental or therapeutic changes across development. This review supports the concept that ELS contributes to the developmental programming of mental health through epigenetic mechanisms affecting stress-response systems. These findings underscore the importance of timing and environmental context in shaping long-term behavioral outcomes. However, the existing literature remains limited by methodological heterogeneity, including variability in developmental stages, tissue types, and measurement approaches. Future research should prioritize longitudinal and developmentally informed designs to better capture the dynamic interplay between environment, biology, and behavior across the lifespan. - Source: PubMed
Okan NesrullahKöse Nihat - : Rheumatoid arthritis (RA) is a chronic autoimmune disease frequently accompanied by depression, with persistent inflammation, oxidative stress, and neuroimmune dysfunction contributing to disease progression. This study evaluated the therapeutic efficacy of a Gum Arabic-stabilized bioactive oil blend nanoemulsion and investigated its underlying mechanisms using molecular docking and network pharmacology. : A lyophilized nanoemulsion prepared from grape seed oil, wheat germ oil, and avocado peel oil was characterized for physicochemical properties and phytochemical composition. Female rats with Freund's complete adjuvant-induced rheumatoid arthritis received the nanoemulsion at two doses. Paw inflammation, behavioral performance, inflammatory cytokines, oxidative stress biomarkers, acetylcholinesterase concentration, lipid profile, and liver and kidney function were evaluated. Molecular docking and network pharmacology analyses were performed to identify potential molecular targets and signaling pathways. : The nanoemulsion exhibited favorable physicochemical characteristics and was rich in phenolic compounds, flavonoids, phytosterols, tocopherols, and unsaturated fatty acids. Treatment significantly reduced paw inflammation, TNF-α, IL-6, malondialdehyde, and acetylcholinesterase while enhancing catalase activity, improving metabolic parameters, and alleviating depression-like behavior. Molecular docking demonstrated favorable binding of the major phytochemicals to TNF-α, IL-6, and acetylcholinesterase. Network pharmacology identified key therapeutic targets, including TNF, AKT1, PTGS2, IL6, STAT3, ESR1, and NR3C1, and revealed enrichment of inflammatory, oxidative stress, and neuroimmune signaling pathways. : The Gum Arabic-stabilized bioactive oil blend nanoemulsion ameliorated rheumatoid arthritis-associated depression-like behavior through a multi-component-multi-target-multi-pathway mechanism involving coordinated regulation of inflammatory, oxidative stress, cholinergic, and neuroimmune pathways. These findings support its potential as a complementary nutraceutical strategy for rheumatoid arthritis and its associated neurobehavioral complications. - Source: PubMed
Publication date: 2026/08/27
Mohamed Doha AMabrok Hoda BElbakry Hagar FEl-Shamarka Marwa EBassuoni Rania A - Stress urinary incontinence (SUI) is conventionally viewed as a peripheral mechanical disorder, yet its psychological burden suggests that a broader biopsychosocial interpretation may be warranted. This perspective considers whether recurrent leakage, anticipatory anxiety, behavioural avoidance, and social evaluative threat may allow SUI to function as a chronic psychosocial stressor. It integrates clinical observations with established concepts in stress physiology, hypothalamic-pituitary-adrenal (HPA) axis regulation, allostatic load, inflammation, and stress-related epigenetic mechanisms, including FKBP5 and NR3C1. Direct molecular evidence in SUI populations remains limited; therefore, the proposed links are presented as a hypothesis-generating framework rather than as established causal pathways. The framework further emphasises the heterogeneity of patient outcomes. Differences in perceived symptom burden, coping, stress responsivity, prior vulnerability, and resilience may help explain why psychological symptoms improve after treatment in some individuals yet persist in others. These interacting psychosocial and biological processes may reinforce a feedback loop between symptom-related threat, sustained stress activation, and affective vulnerability. By moving beyond a solely mechanical model, this perspective supports a more interdisciplinary approach combining urogynecological and psychological assessment. The proposed stress-epigenetic framework is intended to guide future longitudinal and biomarker-informed research and to encourage more integrated approaches to the prevention and management of psychological burden in SUI. - Source: PubMed
Publication date: 2026/09/15
Drivakou DespoinaRoussos NikolaosTheodoulidis IakovosDinas KonstantinosMikos ThemistoklisKosmidis Mary H - Many studies have focused on identifying specific biomarkers for the early diagnosis of non-traumatic osteonecrosis of the femoral head (NONFH). This systematic review aims to summarize biomarkers associated with the diagnosis and progression prediction of NONFH, thereby providing a molecular level foundation for clinical diagnosis and targeted treatment. - Source: PubMed
Publication date: 2026/09/21
Dong YaweiSun JigaoLi ShuwenZhang JiawenYan YanLi TaixianJia Yan - GPR55 has attracted attention for its anti-inflammatory, neuroprotective, and neurotransmitter-modulating properties, suggesting a role in mood regulation. Here, we aimed to clarify the contribution of GPR55 to emotional responses. - Source: PubMed
Publication date: 2026/09/03
García-Gutiérrez María SIllescas LucíaGasparyan AniManzanares Jorge