SLPI_HUMAN WAP4 ELISA tesk kit
- Known as:
- SLPI_HUMAN WAP4 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16904
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- SLPI_HUMAN WAP4 ELISA tesk kit
Related genes to: SLPI_HUMAN WAP4 ELISA tesk kit
- Gene:
- SLPI NIH gene
- Name:
- secretory leukocyte peptidase inhibitor
- Previous symbol:
- -
- Synonyms:
- HUSI-I, ALK1, ALP, BLPI, HUSI, WAP4, WFDC4
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-24
- Date modifiied:
- 2014-11-19
Related products to: SLPI_HUMAN WAP4 ELISA tesk kit
Related articles to: SLPI_HUMAN WAP4 ELISA tesk kit
- Skeletal muscle, accounting for about 40% of the body's mass, is an important trait for farm animal production. Skeletal muscle satellite cells (MuSCs) are an excellent material for studying the regulatory mechanisms underlying muscle growth and regeneration after birth. Here, we analyzed the role and underlying mechanisms of Myc-associated zinc finger protein (MAZ) and secretory leukocyte protease inhibitor (SLPI) in porcine MuSC (pMuSC) proliferation for the first time. It was revealed that both and advanced the proliferation of pMuSCs by promoting cell cycle progression, and that a axis regulated pMuSC proliferation. It was further shown that this axis regulated pMuSC proliferation through the Wnt/β-catenin pathway. The proliferative role obtained above was confirmed in mouse myoblast C2C12 cells. Additionally, a single-nucleotide polymorphism (SNP), -360C>T, which frequently occurred in the promoter of the SLPI gene from Min, Yorkshire, and Longmin black pigs, was found to significantly increase the gene's expression in vitro and in vivo. The SNP -360C>T in is a potential molecular marker predicting the proliferative ability of pMuSCs. The data provide a basis for controlling muscle growth and regeneration, which will provide benefits for improving the meat production of pigs and controlling muscle-related diseases in humans. - Source: PubMed
Publication date: 2026/07/19
Song MengkeZhu RongruZhang QianLi MengTian MingHe XinmiaoYang Xiuqin - Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disorder driven by neuroinflammation involving activated microglia and astrocytes, which accelerates the loss of motor neurons. While Secretory leukocyte protease inhibitor (SLPI) is known for its immunomodulatory properties, its specific role in ALS pathogenesis has not been fully established. This study aimed to characterize the expression patterns and functional significance of SLPI in ALS models. - Source: PubMed
Publication date: 2026/07/17
Li Ming-AnSong Yi-ZhiLi TingWu JianTao YueHu RuiQiao Chen-MengCui ChunZhao Wei-JiangShen Yan-Qin - Peripheral nerves contribute to tumor progression, but the mechanisms by which neural signals regulate cancer cell plasticity and immune resistance remain unclear. Using a paired murine model of intraneural and nonintraneural tumor growth with single-cell RNA sequencing, we identified a nerve-associated cancer cell state marked by increased expression of secretory leukocyte protease inhibitor (SLPI). SLPI was elevated in intraneural tumors and in human tumors with perineural invasion. Sensory neuron-derived substance P (SP) induced SLPI secretion through tumor cell TACR1, whereas sensory denervation or TACR1 blockade reduced SLPI production. SLPI cancer cells were enriched for WNT/β-catenin and stemness programs. Consistent with this, SLPI increased β-catenin and c-MYC expression, expanded ALDH stem-like cells, and enhanced mammosphere formation, whereas Slpi deletion reduced stemness and impaired tumor growth in vivo. SLPI also limited immune-mediated tumor cell killing. Proteomic and biochemical analyses identified granzyme B as a direct SLPI-binding partner, and SLPI inhibited granzyme B-dependent cleavage of caspase-3 and gasdermin E, thereby reducing cytotoxic lymphocyte-induced cell death. In immunocompetent mouse models, pharmacologic inhibition of the upstream SP-TACR1 pathway with aprepitant synergized with anti-PD-1 therapy. In clinical datasets, high SLPI expression was associated with residual disease after immunotherapy, poor response, and adverse outcome. Together, these findings identify the SP-TACR1-SLPI axis as a neural pathway linking cancer stemness to immune escape and nominate this pathway as a target for combination immunotherapy. - Source: PubMed
Publication date: 2026/07/13
Zhang HuiWu QiWang LiHu XiezongLi ShuraoTang MengMa XiaopengWang JiabeiHu Qingsong - Reproductive efficiency in swamp buffalo () remains constrained by the lack of molecular tools to identify fertile females before service. The aim of this study was to discover biologically grounded biomarkers of fertility. - Source: PubMed
Publication date: 2026/05/14
Yusuf MuhammadToleng Abdul LatiefHasrin HasrinBaharun AbdullahDiansyah Athhar ManabiKaiin Ekayanti MulyatiMasturi MasturiSahiruddin SahiruddinJannah Miftahul - Pubertal initiation critically determines reproductive performance in female pigs. Histone H3 lysine 27 trimethylation (H3K27me3) has been implicated in ovarian development. However, its genome-wide regulatory landscape during the pubertal transition remains unexplored. Here, we obtained transcriptomes of GCs treated with the pharmacological H3K27me3 agonist GSK-J4 or H3K27me3 inhibitor EPZ005687. We found that H3K27me3 substantially remodels the transcriptomic landscape of porcine GCs, with differentially expressed genes significantly enriched in pathways governing cell proliferation and apoptosis. Mechanistically, H3K27me3 suppressed GC proliferation by downregulating the expression of and promoting apoptosis through upregulation of , thereby delaying pubertal initiation. Furthermore, genome-wide ChIP-seq analysis on porcine ovaries from pre-pubertal and in-pubertal gilts revealed higher H3K27me3 enrichment around transcription start sites in the In-puberty stage than in the Pre-puberty stage. Genes with promoters exhibiting reduced H3K27me3 occupancy during the pubertal transition were enriched in pathways related to sex differentiation and serine-type endopeptidase inhibitor activity. Notably, secretory leukocyte peptidase inhibitor () was identified by ChIP-qPCR as a direct target repressed by H3K27me3. Functional validation demonstrated that promoted GC proliferation and inhibited GC apoptosis in vitro. Intraperitoneal injection of LV- or sh- into C57BL/6J mice showed that accelerated pubertal initiation of mice in vivo. Collectively, our findings confirmed that developmental stage-specific loss of H3K27me3 at the promoter derepressed transcription, which in turn promoted porcine GC proliferation, suppressed apoptosis, and facilitated pubertal initiation in mice. These results provided valuable insights into the epigenetic regulation of pubertal initiation in mammals. - Source: PubMed
Publication date: 2026/06/25
He YingtingWang RuiqiWang TiantianShao JiahaoDuan WenmiaoYang JinghaoZhong YuyiYuan XiaolongLi Jiaqi