PIGR_PIG PIgR ELISA tesk kit
- Known as:
- PIGR_PIG PIgR Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16550
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- PIGR_PIG PIgR ELISA tesk kit
Related genes to: PIGR_PIG PIgR ELISA tesk kit
- Gene:
- PIGR NIH gene
- Name:
- polymeric immunoglobulin receptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-06
- Date modifiied:
- 2016-10-05
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- Bacterial pathogens, including Flavobacterium oreochromis, Aeromonas veronii, Streptococcus agalactiae, and Edwardsiella tarda, represent major infectious threats to Nile tilapia (Oreochromis niloticus). A multivalent vaccination strategy integrating cationic nanoemulsion immersion with oral hydrogel boosters was developed to investigate tissue-specific immune responses at the transcriptomic level. Gill tissues were collected following immersion challenge and intestinal tissues following intraperitoneal injection challenge, reflecting the physiologically relevant infection biology of each pathogen and the mechanistic rationale of each delivery platform. RNA sequencing (RNA-seq) generated high-quality datasets (mapping rate > 81.64%) with strong concordance to quantitative real-time PCR (qRT-PCR) validation (r = 0.83). Comparative transcriptomic analysis revealed distinct yet complementary immune signatures between tissues. Gill transcriptomes were enriched in phagosome, focal adhesion, extracellular matrix-receptor interaction (ECM-receptor interaction), and cytokine-cytokine receptor interaction pathways, accompanied by increased expression of major histocompatibility complex class I/II (MHC class I/II), mannose receptor, αVβ3 integrin, and calnexin, indicating innate activation, enhanced phagocytic capacity, epithelial barrier reinforcement, and adaptive immune coordination. Intestinal transcriptomes showed predominant enrichment of adaptive immune pathways, including the intestinal immune network for immunoglobulin (Ig) production, Forkhead box O (FoxO) signaling, and mitogen-activated protein kinase (MAPK) signaling, with increased expression of T-cell receptor (TCR), inducible T-cell co-stimulator ligand (ICOS-L), C-X-C chemokine receptor type 4 (CXCR4), and polymeric immunoglobulin receptor (pIgR), reflecting T and B cell coordination, lymphocyte trafficking, and mucosal immunoglobulin transport, alongside innate engagement through phagosome pathway enrichment. Shared upregulation of MHC class II, B-cell receptor (BCR) signaling, integrin alpha M (ITGAM), and immunoglobulin-associated components across both tissues suggests coordinated mucosal immune activation through a conserved immune module, warranting direct experimental validation. Collectively, these findings provide transcriptomic evidence that this vaccination strategy elicits an integrated, tissue-specialized immune response, advancing mechanistic understanding of gill and intestinal immunity in vaccine-induced protection of teleost fish. - Source: PubMed
Publication date: 2026/06/24
Kumwan BenchawanMeachasompop PakaponAdisornprasert YosaponPhaksopa JitrapornBuncharoen WararutThangsunan PatcharapongThangsunan PattanapongSrisapoome PrapansakRodkhum ChannarongPaankhao NatthapongKingwascharapong PassakornUchuwittayakul Anurak - Few strategies have been developed to mimic and control the supramolecular degradations induced by spontaneous fermentation in sour cassava starch, which are partly responsible for its characteristic expansion capacity in breadmaking, and their effectiveness has remained limited. In this context, the objective of this study was to evaluate the effect of adding α-amylase on the functional and nutritional properties of cassava starch used in breadmaking. Cassava starch from the INIAP 651 variety was modified with different α-amylase dosages (0, 2, 4, 6, 8, and 9 U/g α-amylase for 20 min), followed by hydration and pre-gelatinization before baking. Determinations of the specific volume of the bread (SV), dough characterization by Mixolab, pasting properties using a rheometer, and nutritional properties were performed. The treatment with 6 U/g α-amylase showed the best functional properties, achieving the highest SV (4.28 mL/g), C3 (1.67 Nm), C4 (1.11 Nm), and peak viscosity (6550 mPa·s), as well as the lowest setback (1526 mPa·s). In contrast, the treatment with 9 U/g α-amylase exhibited the most favorable nutritional profile, with the lowest estimated glycemic index (51.25) and rapidly digestible starch (15.85 g/100 g). These results confirm that controlled α-amylase dosing modulates cassava starch functionality for breadmaking and glycemic control. - Source: PubMed
Publication date: 2026/06/18
Abad-Quevedo VanessaCornejo FabiolaMaldonado-Alvarado Pedro - Cecal ligation and puncture (CLP) is widely used to develop polymicrobial sepsis model in rodents, yet conventional CLP is not advantageous for evaluating long-term outcomes because most animals succumb without clinically aligned treatment. We therefore implemented source control (SC) combined with antibiotic therapy after CLP to enable post-acute observation and characterize pulmonary immune alterations after abdominal sepsis. - Source: PubMed
Publication date: 2026/06/22
Kato AzusaSaito MasafumiMiyazaki HiromiKearney Bradley MNakashima MasahiroNakashima HiroyukiKoyama KaoruKinoshita Manabu - Effective screening or diagnostic tests for cholangiocarcinoma (CCA) are currently unavailable. Most patients are either asymptomatic or exhibit only mild symptoms in the early stages, which results in delayed medical attention and diagnosis at advanced stages. This highlights the urgent need for a reliable screening method for CCA. - Source: PubMed
Publication date: 2026/06/20
Pimpitak UmapornPrasopdee SattrachaiPholhelm MontineeButthongkomvong KritiyaKulsantiwong JutharatPhanaksri TevaKunjantarachot AnthichaThitapakorn Veerachai - Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, with aging as a major risk factor. This study aimed to investigate age-related proteins potentially involved in COPD pathogenesis. - Source: PubMed
Publication date: 2026/06/10
Li YanpengYang LiChen ChengshuiHu ZhangliZeng JianWang YunZhong Shan