ACACA_HUMAN ACACA ELISA tesk kit
- Known as:
- ACACA_HUMAN ACACA Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16519
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- ACACA_HUMAN ACACA ELISA tesk kit
Related genes to: ACACA_HUMAN ACACA ELISA tesk kit
- Gene:
- ACACA NIH gene
- Name:
- acetyl-CoA carboxylase alpha
- Previous symbol:
- ACAC, ACC
- Synonyms:
- ACC1
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1989-09-11
- Date modifiied:
- 2018-05-03
Related products to: ACACA_HUMAN ACACA ELISA tesk kit
Related articles to: ACACA_HUMAN ACACA ELISA tesk kit
- High-protein diets (HPDs) have the potential to reduce body weight, yet excessive protein intake can induce hepatic metabolic dysregulation and insulin resistance. L-theanine (LTA), a unique amino acid abundantly present in tea leaves, regulates protein metabolism under HPD conditions. However, its influence on glucose and lipid metabolism remains unclear. In this study, Sprague-Dawley rats were fed either a standard maintenance diet (20% of energy from protein) or HPDs containing 30%, 40%, or 50% of energy from protein, and were administered LTA at different doses (0, 100, 200, or 400 mg kg·body weight) for 40 days. A combination of physiological and biochemical assessments, metabolomics, proteomics, and Western blot techniques was used to investigate the regulatory effects and mechanisms of LTA on glucose and lipid metabolism under HPD conditions. The 30% HPD did not cause notable metabolic changes, whereas the 40% and 50% HPDs led to hyperinsulinemia and hepatic lipid accumulation by enhancing gluconeogenesis and fatty acid synthesis while inhibiting fatty acid β-oxidation. LTA alleviated insulin elevation, hepatic steatosis, and lipid droplet accumulation caused by the 40% and 50% HPDs. Mechanistically, LTA enhanced peroxisome proliferator-activated receptor alpha (PPARα) expression and increased acyl-CoA dehydrogenase medium chain (ACADM) expression to promote mitochondrial fatty acid β-oxidation, while decreasing acetyl-CoA carboxylase alpha (ACACA) and phosphoenolpyruvate carboxykinase 1 (PCK1) expression, thereby suppressing lipid synthesis and gluconeogenesis. These findings highlight the potential of LTA to mitigate HPD-associated metabolic alterations, supporting its application as a functional food ingredient for metabolic health management. - Source: PubMed
Publication date: 2026/06/04
Liu ShaLi LanlanYao KaiHe LinYuan YongTan YuepingYin FeiyanGong ZhihuaXiao Wenjun - Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which liver metastasis represents the principal determinant of poor prognosis. Although metastatic dissemination is thought to be driven by highly plastic tumor cells, the transcriptional features of liver metastasis-related initial cell (LMIC) and its spatial crosstalk with the metastatic microenvironment during PDAC progression remain incompletely defined. - Source: PubMed
Publication date: 2026/06/16
Li YangLiu Ya-DieJiang Zhi-YingLu Hong-Xiang - This study aimed to assess the effects of different nitrogen supplementation strategies during mid-gestation on postnatal performance, skeletal muscle gene expression and morphology and nutritional and metabolic parameters of beef offspring during both the cow-calf and backgrounding phases. Thirty Zebu cows (532 ± 11 kg of body weight [BW]) were used. The following treatments were randomly assigned to cows from 127 ± 17 to 227 ± 17 days of gestation: (1) Control (CON; n = 10): basal diet (corn silage + sugarcane bagasse) and a mineral supplement with urea (60 g/100 kg BW); (2) Rumen-degradable protein (RDP; n = 10): basal diet plus a commercial protein supplement (250 g/100 kg BW) and ground corn (44 g/100 kg BW); and (3) Rumen-undegradable protein (RUP; n = 10): basal diet plus protected soybean meal (3.5 g/kg BW) and a mineral supplement with urea (60 g/100 kg BW). After supplementation, cows were managed as a single group on pasture. Offspring were evaluated during the cow-calf phase, and in a 60-day feedlot backgrounding phase. At the end of the supplementation period (227 days of gestation), cows in the RUP treatment had greater BW compared to those in the CON and RDP treatments (p = 0.01). Near parturition (282 days of gestation), no differences in BW were observed among treatments (p = 0.28). Birth weight was greater in the RUP group compared to the CON and RDP groups (p = 0.04), with no differences between the CON and RDP. No effects of treatment were observed on offspring weaning weight, average daily gain, ultrasound carcass traits, nutrient intake, apparent total tract digestibility, ingestive behaviour or muscle fibre number and histomorphometry (p > 0.05). At 346 ± 31 days of age, RUP offspring exhibited increased expression of skeletal muscle genes, including ACACA, FASN, PPARG, CPT2, IGF1R and COL3A1 compared to the CON group (p ≤ 0.05). Additionally, RUP offspring showed greater expression of ACACA, FABP4, PPARA, SCD1, COL3A1 and IGFR1 compared to RDP offspring (p ≤ 0.04). In conclusion, maternal supplementation with rumen-protected protein during mid-gestation enhances foetal growth and induces beneficial transcriptional adaptations in skeletal muscle compared to non-protein or RDP supplementation strategies, without affecting postnatal growth performance. - Source: PubMed
Publication date: 2026/06/16
Santos Luana Ruiz DosNascimento Karolina BatistaGuimarães Gustavo Diasde Oliveira Damásio Gabrielde Torres Richardson Antonio CarvalhoFávero Igor GomesBorges Lucas Peralta Carneirode Oliveira IsabellaMeneses Javier Andrés MorenoSerão Nick Vergara LopesGionbelli Tathyane Ramalho SantosCasagrande Daniel Rumede Duarte Marcio SouzaGionbelli Mateus Pies - The impact of metabolic reprogramming on immune cell functions is increasingly recognized. However, it remains largely unexplored in terms of immune cells adaptation during reproduction. Dendritic cells (DC) are crucial for establishing and maintaining pregnancy by orchestrating maternal immune adaptation essential for embryo implantation and decidualization. Here, we characterized the phenotypic and metabolic characteristics of DCs during early pregnancy in an allogeneic mouse model and in response to the specific deletion of hormonal receptors on DCs. Frequency of uterine CD11c DCs on gestational day (gd) 7.5 remained equal to that of non-pregnant mice. However, we observed a functional shift from cDC1 to cDC2 in pregnant mice. In parallel, a metabolic switch in uterine DCs was identified by upregulation of genes representing fatty acid synthesis (, ), fatty acid oxidation (), and glutamine-related metabolic pathways (). The cell-specific deletion of the glucocorticoid receptor in DCs reduced their MHCII expression, accompanied by a reduction in expression. Glutamine deprivation i dramatically reduced the absolute number of cultured bone marrow cells and the frequency of cDC1s while simultaneously increasing the frequency of cDC2s. Collectively, these findings establish glutamine metabolism as a key driver of DC adaptation during early pregnancy, revealing novel metabolic-immunological crosstalk at the maternal-fetal interface. - Source: PubMed
Publication date: 2026/06/15
Cai SongchenWieczorek AgnesUrbschat ChristopherSolano Maria EmiliaZeng YongArck Petra ClaraDiao LianghuiThiele Kristin - The interaction between fatty acids and nanoparticles (NPs) is increasingly recognized. This study investigated how stearic acid (SA)/linolenic acid (LNA) and SiO NPs co-exposure affects mRNA abundance of efflux, autophagy, fatty acid metabolism, and synthesis genes in adult zebrafish, and Si concentrations and lipid accumulation in Caco-2 and HepG2 cells. In vivo, SA or LNA inhibited SiO NPs from inducing abcg1 expression, and SiO NPs and SA/LNA co-exposure decreased agap1 expression in intestines. In livers, SiO NPs and SA co-exposure increased abcg1 expression. SiO NPs increased autophagic gene expression (map 1lc3b, atg7, and becn1) in intestines but not in livers. In contrast, SiO NPs + LNA increased map 1lc3b and atg7 expression, and SiO NPs + SA increased atg5 and becn1 expression in livers. For fatty acid β-oxidation genes, SiO NPs increased acox1 expression but decreased pparaa expression in intestines, an effect altered by SA or LNA. In livers, SiO NPs decreased acox1, cpt1aa, and pparaa but increased pnpla2 expression, which was also changed by SA. For fatty acid synthesis genes, LNA increased acaca and fasn expression in SiO NP-exposed intestines. In livers, SiO NPs decreased acaca, fasn, and scd expression, which was increased by LNA. In vitro, LNA increased Si accumulation in SiO NP-exposed Caco-2 cells, whereas both fatty acids reduced Si levels in HepG2 cells. Lipid accumulation was enhanced in HepG2 cells exposed to LNA and SiO NPs + LNA. Overall, our findings highlighted the complex interplay between SiO NPs and fatty acids, with outcomes dependent on fatty acid structure and cell/tissue type. - Source: PubMed
Publication date: 2026/06/12
Lin WeiqiLi ShanmanNing JiaxinyuGan LuCao Yi