ETAA1_HUMAN ETAA16 ELISA tesk kit
- Known as:
- ETAA1_HUMAN ETAA16 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16435
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- ETAA1_HUMAN ETAA16 ELISA tesk kit
Related genes to: ETAA1_HUMAN ETAA16 ELISA tesk kit
- Gene:
- ETAA1 NIH gene
- Name:
- ETAA1 activator of ATR kinase
- Previous symbol:
- -
- Synonyms:
- ETAA16
- Chromosome:
- 2p14
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-14
- Date modifiied:
- 2019-01-25
Related products to: ETAA1_HUMAN ETAA16 ELISA tesk kit
Related articles to: ETAA1_HUMAN ETAA16 ELISA tesk kit
- BACKGROUND: Understanding the genetic basis of adaptation to extreme environments is crucial in evolutionary biology. Gannan Tibetan sheep, which thrive in high altitudes with thin air and cold climates, demonstrate remarkable resilience. However, the genetic basis of their adaptations remains poorly understood. In this study, we conducted whole-genome resequencing of three indigenous Tibetan sheep breeds, including Ganjia (n = 12), Oula (n = 12), Kecai (n = 12), from the Gannan Tibetan Autonomous Prefecture (average altitude of 3,500 m) in China. By integrating our data with previously published genomic data of sheep from northern China (Altitude below 1,500 m), we examined the genetic population structure, ancestry components, and signatures of positive selection. RESULTS: Our analyses, including principal component analysis, neighbor-joining tree construction, and ADMIXTURE, revealed that the three indigenous Tibetan sheep breeds share a common ancestry with other Tibetan sheep breeds, yet exhibit distinct population differentiation. Moreover, all three breeds display high genetic diversity, which enhances their adaptation to harsh local environments. Through selective sweep analysis, we identified genes associated with cold tolerance and high-altitude adaptation. These genes are involved in mitochondrial function and oxidative stress (LONP1, NDUFA11, NDUFB4 and HSD11B1L), cardiorespiratory and vascular function (FECH, TNFAIP3), and fat metabolism and thermogenesis (ACSL6, PDGFD, CES3, MTCH2, TMEM8B, SPAG8, ETAA1, ZIC1, ATG5, and HAO2). Additionally, we identified candidate regions containing genes related to immunity and physical traits. CONCLUSION: This study provides a comprehensive overview of the genomic variations, ancestry compositions, and selective signals linked to high-altitude traits in Gannan indigenous Tibetan sheep. Our findings offer valuable insights into the breeding and management of Tibetan sheep. - Source: PubMed
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Onder GizemOzdemir OzkanTaylan FulyaCanpolat CengizYalcin KorayErbey FatihSozmen Banu OflazAsarcikli FikretBayhan TuranAkcabelen Yunus MuratYarali NeseOzbek Namik YasarBozkaya Ikbal OkKacar DilekErgun BerkAkkus AlperAlbayrak DavutInce ElifDemirsoy UgurOzdemir Gul NihalDogru OmerAras SedaAydin EylulUnal BusraAmanvermez UfukDogan Ozlem AkgunAkyoney SezerSayitoglu MugeNordgren AnnBugra Agaoglu NihatOzbek UgurNg Ozden Hatirnaz - Xinjiang Brown cattle is an elite dual-purpose breed (raised for dairy and beef) developed in China. To elucidate its genomic architecture, we conducted whole-genome resequencing of 169 Xinjiang Brown cattle, followed by structural variation (SV) detection and a genome-wide association study (GWAS). We identified 71,668 SVs, among which deletions were the most prevalent, followed by translocations, inversions, duplications, and insertions. We further identified 1286 high-frequency SVs involving 2016 protein-coding genes. Through functional enrichment analysis of these genes, we revealed associations of genetic variation at genomic positions near genes implicated in immune response and disease resistance ( and ), growth and development ( and ), and milk production (, , and ). GWAS analysis of 31 body conformation traits revealed 58 SVs significantly associated with five traits (chest width, rear udder width, udder depth, rump width, and heel depth) at the genome-wide level. Additionally, nine candidate genes (, , , , , , , , and ) were identified as potentially involved in the genetic regulation of body conformation traits. These findings provide novel insights for genetic improvement strategies and indicate that precision breeding could further enhance the production performance of this breed in the future. - Source: PubMed
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Wang DanZhang TaoZhang MenghuaChen QiumingYan MengjieMa ShengchaoWang JiangkunZhang XiaoxueMa KailunXu LeiHuang Xixia - ETAA1 is recruited to DNA damage sites via its RPA -binding and ATR -activating domain (AAD) motifs, where RPA binding is crucial for ETAA1's regulation of ATR activity. - Source: PubMed
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