LIPS_RAT Lipe ELISA tesk kit
- Known as:
- LIPS_RAT Lipe Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16431
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- LIPS_RAT Lipe ELISA tesk kit
Related genes to: LIPS_RAT Lipe ELISA tesk kit
- Gene:
- LIPE NIH gene
- Name:
- lipase E, hormone sensitive type
- Previous symbol:
- -
- Synonyms:
- HSL
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-02-23
- Date modifiied:
- 2016-02-12
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- Environmental contaminants pose a significant risk to marine species due to their persistence, bioaccumulation, and potential to impair reproduction. In fish, persistent organic pollutants (POPs) are primarily acquired through diet. This study investigated POP accumulation and lipid metabolism in farmed Atlantic cod (Gadus morhua) from early maturation to spawning, integrating chemical analyses with gene expression profiling of lipid- and stress-related pathways. Polychlorinated biphenyls (PCBs) were the most abundant POPs detected, followed by toxaphene, reflecting feed composition. POP concentrations were highest in liver and whole body, lower in gonads and muscle. Maturation was associated with sex-specific changes in gonadal lipid composition, including increased free fatty acids and cholesterol in males, and elevated n-3 polyunsaturated fatty acids in females. In the liver, oxidative stress-related genes (e.g., catalase, cat) and lipid metabolism genes (e.g., ATP citrate lyase, acly) were downregulated, particularly in females. Lipases involved in extracellular uptake (lipoprotein lipase, lpl) and intracellular hydrolysis (lipoprotein lipase, lipe-2) were downregulated in liver and upregulated in gonads. These findings demonstrate that POP accumulation, lipid remodeling, and gene expression are dynamically influenced by reproductive maturation in Atlantic cod. - Source: PubMed
Publication date: 2026/05/14
Bogevik André SVorkamp KatrinPuvanendran VelmuruguMíguez María Fernández - Porcine reproductive and respiratory syndrome virus (PRRSV) exploits host lipid metabolism to support its replication by harnessing lipids and their metabolic derivatives. Lipophagy, a selective autophagic process responsible for lipid droplet (LD) degradation and cellular lipid homeostasis regulation, has been implicated in viral infections, however, its specific role in PRRSV replication has not been investigated. In this study, we found that PRRSV infection triggered lipophagy, resulting in LD depletion and elevated intracellular free fatty acids. Mechanistically, the viral protein NSP2 was essential for PRRSV-induced lipophagy by directly interacting with LD-associated lipases LIPE and PNPLA2, facilitating their binding to MAP1LC3/LC3 via LIR motifs. Both interactions were required for lipophagy-dependent viral replication. Furthermore, we demonstrated that the AMPK signaling pathway critically regulated PRRSV-induced lipophagy. AMPK activation promoted viral replication, whereas its inhibition impaired both lipophagy and viral propagation. Conversely, MTOR signaling acted as a negative regulator of lipophagy, with MTOR inhibition promoting this process. Collectively, these findings established that PRRSV hijacked host lipophagy to facilitate viral replication through NSP2-LIPE-PNPLA2 interactions and an AMPK-MTOR signaling pathway. Our work provided mechanistic insights into viral pathogenesis and highlighted potential therapeutic targets for PRRSV prevention and control.: AMPK: AMP-activated protein kinase; co-IP: co-immunoprecipitation; CQ: chloroquine; CMA: chaperone-mediated autophagy; FFA: free fatty acid; HEK-293T: human embryonic kidney 293T; hpi: hour post infection; LAMP1: lysosome associated membrane protein 1; LD: lipid droplet; LIPA/LAL: lipase A, lysosomal acid type; LIPE/HSL: lipase E, hormone sensitive type; LIRs: LC3-interacting regions; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MGLL: monoglyceride lipase; MG132: carbobenzoxyl-l-leucyl-l-leucyl-l-leucinal; MOI: multiplicity of infection; MTOR: mechanistic target of rapamycin kinase; NSPs: non-structural proteins; ORFs: open reading frames; PNPLA2/ATGL: patatin-like domain 2, triacylglycerol lipase; PRRSV: porcine reproductive and respiratory syndrome virus; SQSTM1/p62: sequestosome 1. - Source: PubMed
Publication date: 2026/05/27
Zhu ZhenbangLin QianwenZhang XinyuZhang MengYan YifanWang WenqiangWen WeiLi Xiangdong - Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the . ASCO Living Guidelines follow the . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information ( and ). Updates are published regularly and can be found on the . - Source: PubMed
Publication date: 2026/05/20
Banerjee RahulCheung Matthew CDerman BenjaminMessersmith HansAl Hadidi SamerBhella SitaChmielewski CynthiaEbraheem Mohammad SKennedy C ToddKumar ShajiLangerak AlanLipe BreaMian HiraRiva EloisaSeth RahulSubramanian LathaUsmani Saad ZWildes Tanya MZanwar SaurabhZhuo YingHicks Lisa K - Aneurysm progression is associated with complex molecular alterations that are insufficiently studied at transcriptomics level. An aneurysm is characterized as a bulge or a weak spot in a blood artery's wall that causes the vessel to abnormally enlarge or balloon, exceeding 50% of its normal diameter. In the present study aneurysm RNA sequencing (RNA-Seq) dataset involving 14 samples, which include 7 controls and 7 treatments was selected for the analysis. Pathway analysis showed the involvement of key genes in major shifts within lipid metabolism pathways. The protein-protein interaction (PPI) network analysis using the STRING database identified key hub genes that were significantly differentially expressed, including LIPE, SREBF1, SCARB2, LPL, PNPLA2, UCP1, CIDEC, DGAT2, CIDEA and FABP4. These key gene-encoded proteins may be prominent drug targets for future interventions aimed at treating aneurysms. - Source: PubMed
Publication date: 2026/03/31
Lois G ShirleyMurugan ShanmugapriyaJaganathan Mohana ShanmugamS Dhanush KumarJ Jino Blessy - Breast cancer (BC) is one of the most common malignancies in women. Lipase E, hormone-sensitive type (LIPE), is a key lipase with potential regulatory roles in tumor lipid metabolism and the immune microenvironment. However, the molecular mechanisms by which LIPE regulates BC progression remain unclear. - Source: PubMed
Publication date: 2026/05/16
Feng XuqinJiang QinghuaHe YongpengLi TingtingChen SilinHu XinPan XianjunYang Wei