PRGR_HUMAN NR3C3 ELISA tesk kit
- Known as:
- PRGR_HUMAN NR3C3 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16346
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- PRGR_HUMAN NR3C3 ELISA tesk kit
Related genes to: PRGR_HUMAN NR3C3 ELISA tesk kit
- Gene:
- PGR NIH gene
- Name:
- progesterone receptor
- Previous symbol:
- -
- Synonyms:
- PR, NR3C3
- Chromosome:
- 11q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2018-07-11
Related products to: PRGR_HUMAN NR3C3 ELISA tesk kit
Related articles to: PRGR_HUMAN NR3C3 ELISA tesk kit
- Abnormal uterine bleeding (AUB) is a highly prevalent gynecological disorder worldwide, for which first-line steroid hormone therapy is limited by well-documented adverse effects. Paridis rhizoma total saponins (PRS) are the core pharmacodynamic material basis of Gongxuening Capsules, a classic traditional Chinese medicine (TCM) formula with well-validated clinical hemostatic efficacy for AUB. However, its active ingredients and underlying therapeutic mechanisms remain largely unclear, especially the potential regulatory role of the gut-reproductive axis. This study aimed to systematically elucidate the anti-AUB mechanism of PRS. - Source: PubMed
Publication date: 2026/07/09
Ren HongminZhao ChongjunFan QiqiWang XuxingYan KailiZhang HaixiaJiang ShuilanYang ChaoWang YujieLiu YiqiWang NaFan ShuoXu XinfangLi Xiangri - We aimed to investigate the prognostic significance of estrogen receptor status (ER)-low status in breast cancer (BC). Additionally, we compared the ER-low subgroup with ER-negative and ER-high BC according to clinical, histopathological and molecular factors. - Source: PubMed
Publication date: 2026/05/06
Huszno JoannaKołosza ZofiaStobiecka EwaPonikiewska DorotaSzcześniak BognaSimek JakubChmielik Ewa - Innovative approaches are urgently needed to improve the phytoremediation of complex mixtures of per- and polyfluoroalkyl substances (PFAS) in contaminated soils. This study investigated the effectiveness of plant growth regulators (PGRs) in enhancing the uptake of a mixture of eight PFAS (100 μg/kg each) by Timothy grass (TG) from soil. A suite of PGRs including auxins (indole-3-acetic acid [IAA], indole-3-butyric acid [IBA]), gibberellic acid (GA), jasmonic acid, α-naphthaleneacetic acid, and 2,4-dichlorophenoxyacetic acid) was applied individually via foliar spray at concentrations ranging from 0.1 to 200 μM. Among all treatments, IBA at 10 μM (IBA-10), IAA-1, and GA at 0.1-1 μM significantly enhanced shoot accumulation of PFHxA and PFHpA, with maximum uptake reaching ∼23% in TG during the second harvest (days 55-108). Compared to the controls without exposure to PGRs, this enhancement was ∼63%. In addition, PGRs enhanced the translocation of long-chain PFOS and PFNA, with increases of 45-82% over the controls. Uptake of ΣPFAS peaked around 7-9% of the total spiked mass for those with IBA-10, IAA-1, or GA-1/GB-0.1, underscoring the importance of type and concentration of PGRs in enhancing phytoextraction. Similar results were also observed for alfalfa undergoing similar treatment with PGRs. Insight from both TG and alfalfa indicates that not all PGR applications led to enhanced biomass weight and PFAS uptake percentage. Some treatments increased tissue PFAS concentrations without improving biomass dry weight, while others enhanced biomass but resulted in only modest increases in PFAS translocation. These results demonstrate that some foliar-applied phytohormones can regulate PFAS accumulation in plants, offering a potential strategy to improve phytoextraction efficiency. The underlying mechanisms, however, will need to be further elucidated. - Source: PubMed
Publication date: 2026/06/05
Ilango Aswin KumarUrucu Oya AydinKharel MadhavLiang Yanna - The pituitary and gonads serve as central regulatory hubs and functional organs for gametogenesis and maturation. In this study, we performed single-cell RNA sequencing (scRNA-seq) of the pituitary and ovary in pre-spawning to elucidate the cellular landscape and regulatory pathways governing gonadal development and oocyte maturation. Pituitaries from four female fish (weight: 43.8 ± 3.2 g; length: 14.1 ± 0.7 cm) and four male fish (weight: 78.2 ± 11.2 g; length: 18.9 ± 1.1 cm) were subjected to single-cell transcriptomic analysis. A total of 17 distinct cell types were identified in the female pituitary, whereas 15 cell types were detected in the male pituitary. Both male and female pituitaries comprised multiple hormone-secreting endocrine populations, indicating a largely conserved cellular composition. However, sex-specific differences were observed in thyrotrope subtypes, suggesting potential sexual dimorphism in pituitary endocrine regulation. Examination of receptor gene expression revealed cell-type-specific regulatory capacities, highlighting gonadotropin, steroid, and neuropeptide responsiveness across pituitary populations. In the ovary, 10 cell types were identified, with granulosa cells (~22.9%) and theca cells (~8.6%) showing distinct transcriptional profiles. Follicle-stimulating hormone receptor () was highly expressed in granulosa cells, whereas luteinizing hormone receptor () and steroidogenic genes (, ) were predominantly localized in theca cells, indicating functional compartmentalization of gonadotropin and steroid signaling. Prostaglandin (PG) and melatonin (MT) pathways were implicated in paracrine regulation: the prostaglandin synthase was expressed in theca, germ, and immune cells, while was expressed in granulosa cells; melatonin synthesis genes (, , ) were confined to granulosa cells, with receptors () in germ cells. These findings suggest that ovarian paracrine signaling complements systemic endocrine control to modulate oocyte maturation and ovulation. This single-cell atlas provides a high-resolution framework of reproductive cell types and signaling networks in , offering insights for improving artificial breeding and reproductive management in aquaculture. - Source: PubMed
Publication date: 2026/07/02
Guo YuanqiLi ZhaoxianChen MengjieChen JiTao BinbinLuo HongruiMei JieXiong YangHu WeiSong Yanlong - The current study describes the synthesis and preliminary anticancer assessment of a novel series of C3/C28-bis-1,2,4-triazolyl-sulfanylacetate-betulin (AP1-5) derivatives to identify potent agents for clinical development. The cytotoxicity of AP1-5 was evaluated using the Alamar blue assay against MCF-7, A375, PANC-1 (cancer cells) and HaCat (human keratinocytes) cells. Moreover, the molecular mechanisms responsible for cytotoxicity were investigated through in vitro (DCFDA/HDCDFA assay, caspase-3/7 assay, and morphological analysis) and in silico assays (network pharmacology, molecular docking, molecular dynamics simulation, and ADMET predictions). The result highlighted AP5, containing unsubstituted 1,2,4-triazoles, as the lead derivative of the series with increased potency against MCF-7, with an IC value of 7.41 μM compared to its phenyl-substituted analogs (AP1-4). The derivatives induced apoptosis, marked by fragmented nuclei, round cells, disorganized cytoskeletons, and activation of caspases-3/-7 through a ROS-decreasing mechanism. The network pharmacology assessment predicted AP5 may interact with key proteins in the PI3K/Akt pathway, such as MAP2K1, MDM2, IGF1, JAK2, IL2 and FGFR1, as well as ESR1, PGR and MMP2. Molecular docking suggested MMP-2 is the most favorable target for AP5 among the validated proteins, while molecular dynamics simulations supported the predicted AP5-MMP-2 interaction. Moreover, the ADMET profiling of AP5 showed acceptable intestinal absorption, non-glycoprotein-P substrate status, and reduced hepatic metabolism compared to betulin. However, the ADMET analysis also highlighted some potential toxicity risks such as DILI, genotoxicity, carcinogenicity and skin sensitization that need to be further investigated. Altogether, these promising findings support the further exploration of AP5 as a promising drug candidate for breast cancer in vivo to assess its potency and toxicity. - Source: PubMed
Publication date: 2026/07/02
Prodea AlexandraMioc MariusMunteanu AndreeaMioc AlexandraPaşcalău Nicoleta AnamariaMara Bogdan-IonuțAtyim ElisabetaBalan-Porcarasu MihaelaRacoviceanu RoxanaȘoica Codruța