PRGR_CHICK NR3C3 ELISA tesk kit
- Known as:
- PRGR_CHICK NR3C3 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16341
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- PRGR_CHICK NR3C3 ELISA tesk kit
Ask about this productRelated genes to: PRGR_CHICK NR3C3 ELISA tesk kit
- Gene:
- PGR NIH gene
- Name:
- progesterone receptor
- Previous symbol:
- -
- Synonyms:
- PR, NR3C3
- Chromosome:
- 11q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2018-07-11
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- Polycystic ovarian syndrome (PCOS) is an intricate endocrine and metabolic disorder affecting reproductive-age women. This research focused on assessing the therapeutic potential of harmine in letrozole-induced PCOS rat model. PCOS was induced in all the groups except normal control by oral administration of letrozole (1 mg/kg) for consecutive 28 days. After confirmation of PCOS, normal and disease controls were treated with vehicle, clomiphene citrate (5.25 mg/kg) was administered as a standard drug, and harmine as treatment compound at 2.5, 5.0, and 10 mg/kg orally for 28 days daily. Letrozole administration in diseased rats displayed disrupted estrous cycle irregularity, insulin resistance, cystic ovarian morphology, and hyperandrogenism along with upregulation of metabolic and lipid profile and alteration in hormonal and hematological parameters. Treatment with harmine (2.5-10 mg/kg) was remarkably (p < 0.05) normalize the metabolic and lipid profile, restored the hormonal imbalance, and improved ovarian histology. Treatment with harmine (2.5-10 mg/kg) notably reduced the serum level TNF-α, and IL-6 in contrast to disease control. Harmine-treated rats exhibited the down regulation of mRNA expression of TNF-α, IL-6, PGR, and Keap-1 while upregulated FSHR, CYP19A1, and Nfr-2 as equated to disease control. However, harmine demonstrated dose-dependent improvement in mRNA expression that linked with ovarian function. These findings concluded that harmine exhibited promising therapeutic potential for PCOS by modulating metabolic, endocrine, anti-oxidant, anti-inflammatory, and steroidogenic markers. Besides, harmine was safe in acute usage and LD50 > 2000 mg/kg. - Source: PubMed
Publication date: 2026/06/06
Ahmad AqsaSaleem Ammara - The ryanodine receptor (RyR2) is an intracellular Ca release channel which mediates numerous cellular functions across different tissues. Dysregulation of RyR2 channel activity leads to pathological Ca release, which often underlies disrupted cellular signaling in disease states. In the heart, RyR2 channels forms discrete clusters and calcium release units (CRUs) which control channel activity. These structures demonstrate nanoscale remodeling in disease states associated with pathological Ca release activity in the heart. Hence, these nanoscale structures are critical in regulating Ca release in health and disease. RyR2 is also expressed in brain; however, whether analogous clusters and CRUs form in neurons remains unexplored. - Source: PubMed
Munro Michelle LSilva Ruben VergaraOhline Shane MKhaing Ei PhyoChan Joan AIbrahim Mohamed FTausi Tausi FAbraham Wickliffe CJones Peter P - Plant growth regulators (PGRs) play a crucial role in regulating the biochemical and physiological processes. Recently, nanoparticle-based approaches have attracted increasing attention for improving in vitro rooting efficiency. Ceratonia siliqua L. is a significant tree species utilized for landscaping and medicinal purposes; however, its conventional propagation is limited, making micropropagation a viable alternative. This study aimed to optimize in vitro multiplication, rooting, and secondary metabolite accumulation of C. siliqua through the use of different PGR combinations, Murashige and Skoog (MS) medium strength, and riboflavin during the multiplication stage, while evaluating the effect of iron oxide nanoparticles (Fe₂O₃ NPs) exclusively during the rooting stage. During establishment and multiplication, explants were cultured on full- or half-strength MS media supplemented with riboflavin in combination with benzyladenine (BA), naphthaleneacetic acid (NAA), and gibberellic acid (GA₃). Rooting experiments were conducted using indole-3-butyric acid (IBA; 2, 3, and 4 mg L) applied alone or in combination with Fe₂O₃ NPs (5 and 10 mg L). Chemical analyses were performed only on responsive multiplication treatments and compared with the mother plant. The highest shoot number (3.33 shoots per explant), shoot length (46.33 mm), and leaf number (42.67 leaves per explant) were recorded on full-strength MS medium supplemented with 1 mg L riboflavin, 1 mg L BA, 0.1 mg L NAA, and 0.1 mg L GA₃, which also resulted in the highest flavonoid content in the multiplied shootlets. For rooting, the highest rooting percentage and root number were obtained with 3 mg L IBA alone or in combination with 5 mg L Fe₂O₃ NPs. Regarding secondary metabolites, shoots on ½ MS with 1 mg L⁻¹ riboflavin and 0.5 mg L⁻¹ BA yielded high phenolic content, nearly matching the mother plant, while significantly surpassing it in DPPH antioxidant activity. HPLC confirmed this enhanced bioactivity via the unique accumulation of gallic acid, rutin, and vanillin. - Source: PubMed
Publication date: 2026/06/04
Taha Lobna SYoussef Nora MIbrahim Eman AEl-Sayed Iman M - Stem rust (SR), caused by Puccinia graminis f. sp. tritici (Pgt), poses a threat to wheat production in Germany. This study evaluated 200 plant genetic resources (PGR) and 50 elite lines across four field environments. Multi-environment genome-wide association mapping based on PGR accessions revealed 1942 marker-trait associations (MTAs), grouped into eight quantitative trait loci (QTLs), which explained 0.84%-28.19% of phenotypic variance. Three of these QTL, QSr1B_1.47_67.79, QSr4A_716.31_716.32, and QSr7D_171.80_174.34, harbor five haplotypes that have likely not been used in breeding. Five representative MTAs (Chr1B:25506861, Chr1B:17349639, Chr1B:67755088, Chr4A:716319007, and Chr7D:171807054) represent these five putative novel haplotypes, and together they conservatively explained 2.40%-7.03% of the phenotypic variance. Four genotypes carrying all favorable alleles of the representative MTAs were identified as potential donor lines for future breeding. Within eight QTL regions, 44 candidate genes were prioritized. These findings provide new insights into the genetic architecture of SR resistance and highlight promising targets for marker-assisted prebreeding. - Source: PubMed
Wang JiaojiaoLi GuoliangKloppe TimFlath KerstinSchulz PhilippWiegman MathiasMiedaner ThomasJiang YongReif Jochen C - Gastric cancer (GC) has high mortality due to late diagnosis. Identifying which patients with gastric low-grade intraepithelial neoplasia (LGIN) will progress to high-grade intraepithelial neoplasia (HGIN) or early gastric cancer (EGC) remains challenging. This study aimed to develop a non-invasive method combining serum TFF3 (reflecting malignant transformation) and pepsinogen ratio (PGR, indicating gastric atrophy) to predict progression. - Source: PubMed
Publication date: 2026/06/04
Huang TaoHe JunxiangMao HaohuiShen Biao