ACON_PIG ACO2 ELISA tesk kit
- Known as:
- ACON_PIG ACO2 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16257
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- ACON_PIG ACO2 ELISA tesk kit
Related genes to: ACON_PIG ACO2 ELISA tesk kit
- Gene:
- ACO2 NIH gene
- Name:
- aconitase 2
- Previous symbol:
- -
- Synonyms:
- ACONM
- Chromosome:
- 22q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-12-01
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- The NADPH-dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining redox homeostasis of the cell by transferring electrons from NADPH to target proteins though NTR and TRX, thereby modulating cysteine redox states and regulating enzyme activity. However, the specific contribution of the extraplastidial NTR/TRX system to plant acclimation to elevated CO (eCO) remains poorly understood. Here, we investigated the physiological and metabolic responses of Arabidopsis mutants deficient in mitochondrial TRXo1 (trxo1) or in the cytosolic/mitochondrial/nuclear thioredoxin reductases NTRA/NTRB (ntrantrb) alongside the wild-type (WT), grown under ambient (aCO; 400 ppm) and eCO (800 ppm) CO conditions. The stomatal closure induced by abscisic acid or eCO was partially compromised in ntrantrb double mutant. The stomatal density decreased in WT and ntrantrb plants under eCO, while did not change in trxo1 lines. The mutants showed much higher increases in rosette biomass under eCO compared to WT. This was associated with alterations in both primary and secondary metabolisms, but not to the level of NAD(P)(H), and reduced glutathione/oxidized glutathione (GSH : GSSG) ratio. Our results indicate that TRXo1 and NTRA/B play key roles in regulating stomatal development/movement and both primary and secondary metabolisms, thereby impacting plant acclimation to eCO. - Source: PubMed
Publication date: 2026/05/29
da Fonseca-Pereira PaulaMélo Neto Domingos FMonteiro-Batista Rita de CássiaCoelho Daniel GomesLana-Costa Jaciarade Souza Leonardo PerezKrahnert InaDaloso Danilo MGago JorgeFernie Alisdair RAraújo Wagner LNunes-Nesi Adriano - In aquaculture, disease outbreaks occur amidst complex husbandry factors like feeding schedule and incidental injury. The liver, a central immunometabolic organ, integrates these cues, but the systems-level transcriptional mechanisms governing its response to concurrent stress are poorly defined in channel catfish. We investigated how feeding status and physical injury modulate the hepatic transcriptome during early Aeromonas hydrophila infection in channel catfish. - Source: PubMed
Publication date: 2026/05/28
Soku Yesutor KLange Miles DAbernathy Jason WSankappa Nithin MShoemaker Craig AHayden KarlAndersen Linnea KPhillips IdaNashar TouficSamuel TemesgenMohamed Abdelrahman - Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline in renal function, high morbidity and mortality, and a lack of effective early diagnostic markers or targeted therapies. To address this critical unmet need, we employed an integrated multi-omics and network pharmacology approach to systematically investigate the molecular mechanisms and potential therapeutic targets of AKI. Core targets were identified through differential gene expression (DEG) analysis combined with weighted gene co-expression network analysis (WGCNA), followed by exploration using protein-protein interaction (PPI) networks and pathway enrichment analyses. Inflammation, oxidative stress, and energy metabolism emerged as key pathways involved in AKI pathogenesis. Using ten CytoHubba algorithms and the MCODE module for comprehensive screening, we identified three hub genes-ACO2, FBP1, and PFKL. Their expression patterns and cellular specificity were further characterized using single-cell RNA sequencing data from AKI renal tissues. Additionally, we constructed a miRNA-hub gene regulatory network, providing insights into miRNA-based therapeutic strategies. Molecular docking analysis identified three approved drugs-Ajmaline, Cimetidine, and Tretinoin-with strong binding affinities to the hub proteins, suggesting their potential for repurposing in AKI treatment. Finally, by reviewing knockout mouse models from the Mouse Genome Informatics (MGI) database and conducting in vitro cell experiments, we explored the in vivo and in vitro roles of these core targets, providing experimental evidence of their physiological relevance. Overall, this study integrates cross-cohort transcriptomic profiling, network-based hub prioritization, single-nucleus cell-type localization, translational drug repurposing analyses, and in vitro experimental validation thereby providing a multi-layered framework to prioritize candidate biomarkers for AKI. - Source: PubMed
Publication date: 2026/05/14
Li GuoqiangZeng DianjieWang YinhuaiLiu JiachenYang Dong - Breathing disturbances during sleep are associated with intermittent hypoxaemia, arousal and sympathetic activation, which in turn lead to oxidative stress and cardiovascular and metabolic consequences. However, they are also characterised by fluctuations of carbon dioxide levels, switching between hypercapnia and hypocapnia, which contribute to acute and sustained physiological and cellular effects. Changes in arterial carbon dioxide tension ( ) influence cerebral blood flow, respiratory control and renal function. The complex pathophysiology requires the integration of clinical entities and therapeutical options based on precise measurement of CO Continuous measurements during the night best reflect nocturnal changes in CO levels. Alveolar, arterial, capillary and transcutaneous CO measurements represent distinct characterisations of CO fluctuations. Alveolar and arterial CO levels are very similar and correlate closely to the end-tidal CO ( ) in healthy subjects. However, the validity of is limited in diseases with inhomogeneous lung ventilation and, due to artefacts, during mechanical ventilation. Transcutaneous CO measurement has proven to adequately represent , although time delays in response and absolute figures can differ. Obesity hypoventilation syndrome (OHS) exemplifies a frequent clinical condition with multiple pathophysiological components impacting levels differently across 24 h. Treatment is often delayed due to limited awareness of mild hypercapnia occurring exclusively during night-time. Positive airway pressure (PAP) therapy remains the cornerstone of management. The choice between continuous positive airway pressure or noninvasive ventilation should be guided by the predominant OHS phenotype and the severity of daytime hypercapnia. Management of OHS should also focus on cardiometabolic comorbidities and include a multimodal approach to the underlying obesity. - Source: PubMed
Publication date: 2026/05/13
Randerath Winfried JFanfulla FrancescoPépin Jean Louis - Tissue hypoperfusion can persist despite meeting early goal-directed therapy targets, while excessive resuscitation poses risks. The study focuses on the utility of central venous-arterial CO2 gap to arterial-central venous O2 content difference ratio (Pv-aCO2/Ca-vO2) can serve as a valuable tool for guiding fluid resuscitation in patients with septic shock. - Source: PubMed
Fang Xue-WeiWeng Yi-RuJiang XinWu Ze-TaoYe Gong-Jie