ELOA1_MOUSE EloA ELISA tesk kit
- Known as:
- ELOA1_MOUSE EloA Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16186
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- ELOA1_MOUSE EloA ELISA tesk kit
Related genes to: ELOA1_MOUSE EloA ELISA tesk kit
- Gene:
- ELOA NIH gene
- Name:
- elongin A
- Previous symbol:
- TCEB3
- Synonyms:
- SIII, TCEB3A
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2017-02-10
- Gene:
- REXO1 NIH gene
- Name:
- RNA exonuclease 1 homolog
- Previous symbol:
- TCEB3BP1
- Synonyms:
- EloA-BP1, KIAA1138
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-16
- Date modifiied:
- 2016-06-22
Related products to: ELOA1_MOUSE EloA ELISA tesk kit
Related articles to: ELOA1_MOUSE EloA ELISA tesk kit
- The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. Elongin is composed of a transcriptionally active A subunit, and two positive regulatory B and C subunits. Although the NH(2)-terminal approximately 120 amino acid region of Elongin A is dispensable for its transcriptional activity in vitro, it shares significant sequence similarity with the NH(2)-terminus of other class of transcription factors SII and CRSP70, suggesting that the NH(2)-terminus mediates interactions important for the regulation of transcription in vivo. To identify proteins that can bind to these conserved sequences, a human B cell cDNA library was screened using the NH(2)-terminus of Elongin A as bait in a yeast two-hybrid system. Here, we report on the cloning and characterization of a novel human exonuclease domain-containing protein, Elongin A-binding protein 1 (EloA-BP1). EloA-BP1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. Double immunofluorescence labeling in COS7 cells suggested that EloA-BP1 and Elongin A are colocalized to the cell nucleus. By using an in vitro binding assay, we show that EloA-BP1 is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII. Although the purified EloA-BP1 had no detectable effect on the rate of transcription elongation in vitro, it may play some role in the regulation of elongation in vivo. - Source: PubMed
Tamura KenjiMiyata KeikichiSugahara KazunoriOnishi SaburoShuin TaroAso Teijiro