FABPH_RAT Fabp3 ELISA tesk kit
- Known as:
- FABPH_RAT Fabp3 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16048
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- FABPH_RAT Fabp3 ELISA tesk kit
Related genes to: FABPH_RAT Fabp3 ELISA tesk kit
- Gene:
- FABP3 NIH gene
- Name:
- fatty acid binding protein 3
- Previous symbol:
- MDGI, FABP11
- Synonyms:
- H-FABP, O-FABP
- Chromosome:
- 1p35.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-10-05
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- Horse meat is a high-quality protein source. A total of 50 two-year-old male horses with similar body weights (300 ± 50 kg) were used: 30 for regional comparison (10 each from Bulgan province region of Mongolia (BPM), Tuv province region of Mongolia (TPM), and Inner Mongolia region of China (IMC)) and an additional 20 from the IMC region for muscle-site analysis. To elucidate the molecular mechanisms underlying regional and muscle-site differences in the meat quality of Mongolian horses, with particular emphasis on tenderness, this study analyzed chemical composition, minerals, fatty acids, and transcriptomes. Results showed that Mongolian horses from the Inner Mongolia region of China (IMC) had the highest contents of Se, C17:1, C18:2n6c, C18:3n3, ∑PUFA, PUFA/SFA, ∑n-3PUFA, ∑n-6PUFA ( < 0.05), and Fe ( < 0.01), and the lowest levels of C15:0 ( < 0.01) and C16:0 ( < 0.05). The Mongolian horses from the Tuv province region of Mongolia (TPM) had the highest Ca content ( < 0.05). The Mongolian horses from the Bulgan province region of Mongolia (BPM) had the highest ∑SFA ( < 0.01). The forelimb (FL) had the highest a*, b* ( < 0.01), Fe, Zn, and C17:1 ( < 0.05), and the lowest shear force and drip loss ( < 0.01). The HD had the highest pH and cooking loss ( < 0.01). The hindlimb (HD) increased the L* compared with the FL ( < 0.01). Transcriptomic analysis identified 513 differentially expressed genes (DEGs) between FL and HD, including , , , and . KEGG enrichment analysis revealed that these DEGs were significantly enriched in the cGMP-PKG signaling pathway, glycerophospholipid metabolism, and PPAR signaling pathway. In summary, this study demonstrated that among Mongolian horses from three different regions, IMC horses exhibited superior meat quality and flavor characteristics, and the FL of IMC horses showed significantly better meat quality than other anatomical sites. Transcriptomic analysis identified a set of candidate genes related to meat quality and lipid metabolism, including , , , and , providing a scientific basis for further understanding of muscle-specific molecular mechanisms in Mongolian horses. Furthermore, the observed differences in physicochemical and nutritional properties across regions and muscle sites established a systematic foundation for quality grading, targeted nutritional utilization, and processing optimization of Mongolian horse meat. - Source: PubMed
Publication date: 2026/06/09
Liu YuWang XuejiaoTan GesiDugarjaviina ManglaiZhang Xinzhuang - To investigate whether vitamin D (VD) affects lipid metabolism in granulosa cells in polycystic ovary syndrome (PCOS) through the FABP3-associated PI3K/Akt pathway. - Source: PubMed
Publication date: 2026/06/16
Yang JianshuYuan XinJiang YijieSun DanlinWang TingtingLuo KaimingWang LongXiang ShoukuiLu LiHua Fei - Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of oncology but are increasingly associated with cardiovascular immune-related adverse events (irAEs), including myocarditis, heart failure, arrhythmias, and vascular complications. Among these, ICI-associated myocarditis represents the most severe manifestation, often characterized by high mortality and challenging early diagnosis. Detecting subclinical myocardial injury before irreversible cardiomyocyte necrosis occurs remains a major unmet need in contemporary cardio-oncology. This narrative expert review critically examines the biological rationale, preclinical evidence, and emerging clinical data supporting the potential role of heart-type fatty acid-binding protein (H-FABP) as an adjunctive biomarker of early immune-mediated myocardial injury during ICI therapy. H-FABP is a small cytosolic lipid chaperone abundantly expressed in cardiomyocytes and rapidly released into the circulation following subtle membrane destabilization and metabolic stress, frequently preceding detectable troponin elevation in other forms of myocardial injury. Experimental studies support a mechanistic association between H-FABP release, inflammasome activation, cytokine amplification, mitochondrial dysfunction, and immune-metabolic cardiomyocyte stress. Preliminary clinical observations further suggest that H-FABP elevations may occur during ICI treatment even in the absence of overt myocarditis or concomitant increases in high-sensitivity cardiac troponins (hs-cTns). Although H-FABP cannot replace hs-cTn, which remains the cornerstone biomarker for the diagnosis of clinically significant ICI-associated myocarditis, its rapid kinetics and sensitivity to early metabolic membrane injury support its potential role as an investigational adjunctive biomarker for early surveillance and risk stratification. This approach may be particularly relevant in patients receiving high-risk combination ICI regimens or in individuals with pre-existing cardiovascular disease. However, current evidence remains limited, and large prospective multicenter studies integrating H-FABP with hs-cTns, natriuretic peptides, cardiac magnetic resonance imaging, and clinical outcomes are required before routine clinical implementation can be considered. - Source: PubMed
Publication date: 2026/05/27
Quagliariello VincenzoBerretta MassimilianoMaurea FabrizioCanale Maria LauraPaccone AndreaBisceglia IrmaTedeschi AndreaScherillo MarinoSantagata JacopoOliva StefanoCadeddu Dessalvi ChristianForte PietroD'Ambrosio CristianaDi Matola TizianaGabrielli DomenicoMaurea Nicola - We previously demonstrated that fatty acid-binding protein 3 (FABP3) is significantly upregulated in ischemic neurons, and its inhibition mitigates ischemic brain injury in mice and attenuates mitochondrial damage under rotenone-induced oxidative stress. These findings suggest a potential role for FABP3 in mitochondrial dysfunction in ischemic neurons, although the underlying mechanism remains unclear. In this study, we further investigated the role of FABP3 in mitochondrial injury and apoptosis in ischemic neurons. Our findings indicated that FABP3 deficiency significantly decreased infarct volume following middle cerebral artery occlusion/reperfusion (MCAO/R) in mice, improved cognitive and spontaneous activity deficits, and suppressed BAX activation and mitochondrial translocation, caspase-3 activation, and cytochrome c release. In HT22 cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R), FABP3 deficiency increased cell viability, reduced apoptosis, and alleviated the loss of mitochondrial membrane potential. Conversely, FABP3 overexpression further exacerbated mitochondrial dysfunction and apoptosis, effects that were partially reversed by the BAX inhibitor BAI1. Furthermore, FABP3 overexpression promoted abnormal mitochondrial lipid accumulation and increased lipid peroxidation. Both the mitochondria-targeted antioxidant MitoQ and the ferroptosis inhibitor Ferrostatin-1 alleviated FABP3 overexpression-induced mitochondrial damage and apoptotic signaling. Collectively, our findings suggest that FABP3 is an important promoter of cerebral ischemia-reperfusion injury. FABP3 may aggravate ischemic neuronal injury by promoting abnormal mitochondrial lipid accumulation and lipid peroxidation, thereby enhancing BAX-dependent mitochondrial apoptotic signaling. Targeting FABP3 may provide a potential therapeutic strategy for neuroprotection in ischemic stroke. - Source: PubMed
Publication date: 2026/05/29
Zheng YunsiLuo AnqiFukunaga KohjiLiu QibingGuo Qingyun - Individuals living with frailty have reduced physiological reserve for tolerating health stressors. Myokines are cytokines released from skeletal muscle that have pleiotropic effects throughout the body. Suggested as a means of facilitating earlier identification of frailty, little research has explored the association of myokines with frailty status. - Source: PubMed
Publication date: 2026/05/28
Boreskie Kevin FHay Jacqueline LSchwade DanielSaleem AyeshaArora Rakesh CDuhamel Todd A