FABPH_HUMAN H-FABP ELISA tesk kit
- Known as:
- FABPH_HUMAN H-FABP Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen16031
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- FABPH_HUMAN H-FABP ELISA tesk kit
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Related articles to: FABPH_HUMAN H-FABP ELISA tesk kit
- Individuals living with frailty have reduced physiological reserve for tolerating health stressors. Myokines are cytokines released from skeletal muscle that have pleiotropic effects throughout the body. Suggested as a means of facilitating earlier identification of frailty, little research has explored the association of myokines with frailty status. - Source: PubMed
Publication date: 2026/05/28
Boreskie Kevin FHay Jacqueline LSchwade DanielSaleem AyeshaArora Rakesh CDuhamel Todd A - Drug addiction is a serious brain disorder with widespread somatic, psychological, psychiatric, and legal consequences, characterized by compulsive drug seeking, craving, withdrawal, and relapse, particularly with psychostimulants. A key feature of drugs commonly abused by humans is their ability to enhance dopamine (DA) neurotransmission in mesolimbic circuits, thereby activating DA receptors and altering emotional and motivational behaviors. Recent studies have demonstrated that dopamine D2 receptors (D2Rs), existing both as monomers and as D1/D2 receptor heteromers with dopamine D1 receptors (D1Rs), are critically involved in the neurobiological mechanisms underlying drug addiction. Furthermore, Ca⁺/calmodulin-dependent protein kinase II alpha (CaMKIIα), which interacts with D2Rs and associates with D1/D2 receptor heteromers, plays a pivotal role in regulating the molecular mechanisms of the reward system, primarily through its phosphorylation. In addition, fatty acid-binding protein 3 (FABP3), by forming a complex with the long isoform of the D2 receptor (D2LR), has been shown to contribute significantly to the development of drug addiction. This article first reviews the roles of D2Rs and D1/D2 receptor heteromers in addiction, followed by a discussion of the underlying mechanisms of CaMKII signaling. We further highlight recent advances identifying FABP3 as a potential pharmacological target to mitigate addiction and prevent relapse, offering new avenues for therapeutic development and future clinical interventions. - Source: PubMed
Publication date: 2026/05/29
Jia WenbinHe XuejiaCheng AnHe YongZhao FurongFukunaga KohjiZhao Wei - The Sewa sheep has an important economic value. This study selected mammary gland tissues from Sewa sheep during summer (S) and autumn (A) for transcriptome sequencing to explore the molecular regulatory mechanisms affecting lactation performance. In this experiment, 3566 differentially expressed genes (DEGs) were identified, of which 1837 were up-regulated, and 1729 were down-regulated. DEGs were implicated in the 20 most highly enriched pathways, according to analyses using the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology, such as cell adhesion molecules and Rap1 signalling pathways, which are involved in mammary gland development and milk fat production. Using RT-qPCR, we analysed the expression levels of eight genes across two distinct lactation periods. Our results indicated that butyrophilin subfamily 1 member A (), fatty acid binding protein 3 (), perilipin 2 () and stearoyl-coA desaturase () were downregulated. Conversely, stearoyl-coA desaturase 5 (), cluster of differentiation 52 (), perilipin 1 () and potassium inwardly-rectifying channel, subfamily j, member 3 () exhibited upregulated expression. These genes are primarily related to protein and fat metabolism, synthesis and milk fat formation, indicating the performance differences in mammary glands during various lactation periods may be due to the differential expression of related genes. These findings provide foundational data for mining candidate genes related to sheep lactation regulation and mammary gland development and provide insights into the mechanism of lactation regulation in sheep. - Source: PubMed
Publication date: 2026/05/29
Pan JunruMustafa Shehr BanoZhang ZhenzhenPan ChengLi RuiZhaxi YangzongWei LantingDanba ZhaxiBaijiu ZhaxiSun YuJiayang ZhuomaZhao WangshengSong Tianzeng - : Peripheral arterial disease (PAD) is a widespread but underdiagnosed manifestation of systemic atherosclerosis, associated with high morbidity and mortality. Traditional diagnostic methods such as the ankle-brachial index (ABI) have limited sensitivity in certain populations, highlighting the need for reliable blood-based biomarkers. Fatty Acid Binding Protein 3 (FABP3) has emerged as a robust biomarker with diagnostic utility in PAD. To evaluate the diagnostic performance of FABP3 when used in combination with traditional clinical risk factors for PAD in patients presenting to vascular surgery clinics. : A retrospective analysis was conducted on 657 patients presenting to ambulatory vascular surgery clinics at St. Michael's Hospital. Two logistic regression models were compared: (1) Model A: Included standard clinical risk factors (calf pain, age, smoking, diabetes, hypertension, hypercholesterolemia, coronary artery disease, and signs of chronic limb-threatening ischemia); and (2) Model B: Included the same factors as Model A, plus FABP3 levels. Diagnostic metrics including area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were assessed. : Among 657 patients, 423 had PAD and 234 did not. Model B (FABP3-integrated model) outperformed Model A, with a higher AUC (0.86 vs. 0.82), sensitivity (96% vs. 81%), specificity (84% vs. 67%), PPV (92% vs. 81%), NPV (94% vs. 65%), and diagnostic accuracy (93% vs. 76%). FABP3 also improved detection in asymptomatic PAD patients (84% detected vs. 0%). : Integrating FABP3 with standard clinical risk factors significantly improves PAD diagnosis, especially in asymptomatic and borderline cases. These findings support the potential role of FABP3 in routine PAD screening, warranting further prospective studies for validation. - Source: PubMed
Publication date: 2026/05/11
Syed Muzammil HZamzam AbdelrahmanShaikh FarahRotstein Ori DKlein David JYounes HoussamAbdin RawandQadura Mohammad - Due to the substantial secretory burden, bovine mammary epithelial cells (BMECs) are highly susceptible to endoplasmic reticulum (ER) stress caused by the accumulation of misfolded proteins when protein-folding capacity is overwhelmed. However, how ATF3 regulates ER stress-induced impairment of milk synthesis and apoptosis in BMECs, particularly through its direct transcriptional targets, remains poorly understood. In this study, we investigated the protective role of activating transcription factor 3 (ATF3) against ER stress-induced impairment of milk synthesis in BMECs. Using a tunicamycin-induced ER stress model, we overexpressed in BMECs and performed integrated RNA-seq and ChIP-seq analyses to elucidate the underlying molecular mechanisms. Our results indicated that ER stress disrupted milk protein and fat synthesis in BMECs by suppressing the expression of CSN2, FASN, FABP3 and promoting apoptosis via upregulation of BAX and CASP3. overexpression effectively attenuated these effects, reducing apoptosis and restoring the expression of milk fat-related genes. Transcriptomics demonstrated that ATF3 activated MAPK and PI3K-Akt signaling and lipid metabolism pathways, significantly upregulating key genes involved in fatty acid uptake, transport, and metabolism (, , , ). Integrated RNA-seq and ChIP-seq analyses identified 81 overlapping genes, with , , , and confirmed as direct transcriptional targets of ATF3, mediating its regulation of the MAPK pathway. Collectively, these findings elucidate the protective role of ATF3 against ER stress-induced lactation disruption and offer potential molecular targets for enhancing lactation resilience in dairy cattle under stress. - Source: PubMed
Publication date: 2026/05/10
Zhang ChenDai WentingLiu YueXu HongweiLiu Hongyun