K1C19_RAT Krt19 ELISA tesk kit
- Known as:
- K1C19_RAT Krt19 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15966
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- K1C19_RAT Krt19 ELISA tesk kit
Related genes to: K1C19_RAT Krt19 ELISA tesk kit
- Gene:
- KRT19 NIH gene
- Name:
- keratin 19
- Previous symbol:
- -
- Synonyms:
- K19, CK19, K1CS, MGC15366
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2016-03-09
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- Breast cancer represents a major public health problem worldwide. Despite radical surgery for localized disease, a substantial proportion of patients experience disease recurrence. The aim of this study was to evaluate the expression of the mammaglobin and CK19 genes in sentinel lymph node biopsies from patients with early breast cancer. This descriptive study included 301 sentinel lymph node biopsies from patients with stage I-II breast cancer treated at the San Carlos Clinical Hospital in Madrid, Spain. Metastases were identified using conventional histopathology (H&E), immunohistochemistry (IHC), and molecular detection of mammaglobin and CK19 using PCR-based methods. Associations between variables were assessed using Fisher's exact test with a 95% confidence level. Statistical analyses were performed using STATA 12.0. The predictive value for metastatic involvement was 12.29% for CK19 and 16.61% for mammaglobin, increasing to 19.27% when conventional staining was combined with immunohistochemistry. The overall sensitivity was 68.9%, and the specificity was 93.42%. Mammaglobin showed slightly better diagnostic performance than CK19, and the combined molecular detection of both genes improved diagnostic accuracy when compared with individual markers. Intraoperative molecular evaluation of sentinel lymph nodes using mammaglobin and CK19 is comparable to conventional histopathological assessment combined with immunohistochemistry. The combined RT-PCR detection of both genes improves diagnostic performance and represents a clinically useful complementary tool for the detection of metastatic involvement in early breast cancer. - Source: PubMed
Publication date: 2026/05/16
Zambrano Diana CarolinaMatta Andrés JenuerMaestro de Las Casas María LuisaSua Luz Fernanda - Cell lineage relationship studies in developmental and regenerative biology have been greatly advanced using techniques such as fluorescent labeling driven by cell-type-specific promoters. Nevertheless, unbiased non-invasive tools for distinguishing cell lineages are inevitably desired. Mitochondrial DNA (mtDNA) exhibits wide-range single-nucleotide polymorphisms (SNPs) among individual cells. Here, we aim to distinguish cell types in organs/tissues of the same individual and in the regenerated liver based on the use of mtDNA SNPs. For this, two approaches-"Mitochondrial Alteration Enrichment and Sequencing" (MAESTER) and "mitochondrial single-cell assay for transposase-accessible chromatin with sequencing" (mtscATAC-seq)-were adopted to facilitate the detection of mtDNA SNPs in single cells. With MAESTER, we show that specific cell types in the liver and spleen of the same individual can be successfully defined using collective individual-specific markers composed of panels of unique mtDNA SNP combinations. For its application, we performed partial hepatectomy (PH) on a mouse harboring tdTomato-labeled cholangiocytes following tamoxifen injection and demonstrated that utilizing panels of unique mtDNA SNP combinations detected by mtscATAC-seq in the pre-PH cholangiocytes as markers can faithfully trace the cell fate in the post-PH liver samples. Hence, this approach may serve as an unbiased tool for investigating cell lineage relationships in relevant research areas such as liver regeneration. - Source: PubMed
Publication date: 2026/05/21
Wang ShuaiTu XinyueZhu HaozheGao CeGao JiananWei JinsongShi HuiPeng Jinrong - Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with poor survival rate. Keratin 19 (KRT19) has been suggested as a potential biomarker for various cancers, including PDAC. This study investigated the prognostic role of expression in PDAC using publicly available datasets and bioinformatics analyses. - Source: PubMed
Publication date: 2026/03/23
An Hyung JunCho Kwang BumShin Kyung In - Tumor metastasis is the leading cause of cancer-related mortality, yet the contribution of keratins to this process remains incompletely understood. Here, integrated single-cell and bulk transcriptomic analyses identify keratin 19 (KRT19) within a migration-activated epithelial program as a gene of potential functional relevance. Clinical datasets and tissue microarrays show that KRT19 expression is markedly elevated in gastric cancer and is strongly associated with aggressive pathological features. Functional assays demonstrate that KRT19 depletion impairs cellular migration, invasion, and three-dimensional spheroid infiltration, while while intrasplenic injection of KRT19-silenced cells into male BALB/c nude mice significantly reduces hepatic metastatic colonization, as monitored by serial bioluminescent imaging. Mechanistically, nuclear KRT19 interacts with hnRNPU to facilitate β-TrCP-mediated ubiquitination and degradation of IκBα, thereby sustaining NF-κB activity. Activated NF-κB directly engages the FSCN1 promoter and enhances its transcription, and FSCN1 restoration partially rescues the migratory and metastatic deficits caused by KRT19 knockdown. Together, these findings define a signaling cascade in which an intermediate filament rewires transcriptional programs to control cytoskeletal remodeling and motility, providing mechanistic insight into gastric cancer dissemination and highlighting epithelial structural proteins as underappreciated drivers of metastasis. - Source: PubMed
Publication date: 2026/05/25
Zhou JiajieZi MengliXu ZijieCheng YifanLi RuiqiZhao ShuaiWang JieFu YayanSun LongheTian ZhenZhang ChenkaiFang DengyangZhou YiqiangLi BenSun QiannanRen JunWang Daorong - : Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignancy with limited treatment options and a poor prognosis. Extracellular vesicles (EVs), which play a central role in intercellular communication, have emerged as promising non-invasive biomarkers for both diagnosis and prognosis. This study aimed to identify EV-related genes, construct a more accurate prognostic model using data from multiple databases, and explore the functional roles of key genes in PAAD. : Four publicly available datasets, PAAD_ExoRbase, TcgaTargetGtex-PAAD, GSE62452_GPL6244, and GSE78229_GPL6244, were analyzed, leading to the identification of 40 differentially expressed EV-related genes. Using the Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression, five prognostic genes, , , , , and , were selected to construct a nomogram model for predicting patient outcomes. Single-cell analysis showed that these five genes were expressed in T-proliferative, malignant, and ductal cells. Analyses of immune cell infiltration and immune checkpoints further supported the model's prognostic performance. The regulatory role of the key gene was validated in an in-house cohort and confirmed through in vitro experiments and RNA sequencing. Furthermore, analyses of conditioned medium, EV isolation and characterization, and endothelial tube formation assays demonstrated that EVs derived from CFPAC-1 cells carrying enhanced PAAD angiogenesis through VEGF/VEGFR signaling. - Source: PubMed
Publication date: 2026/05/01
Ma TianyinGongye XiangdongDongzhi CairangMa ShuxianChai YiboGuo Wing-WaWang QikunTian Ming