K1C18_MOUSE Krt18 ELISA tesk kit
- Known as:
- K1C18_MOUSE Krt18 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15831
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- K1C18_MOUSE Krt18 ELISA tesk kit
Related genes to: K1C18_MOUSE Krt18 ELISA tesk kit
- Gene:
- KRT18 NIH gene
- Name:
- keratin 18
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-12
- Date modifiied:
- 2016-10-05
Related products to: K1C18_MOUSE Krt18 ELISA tesk kit
Related articles to: K1C18_MOUSE Krt18 ELISA tesk kit
- Cancer cells can acquire neuron-like characteristics ("neural mimicry") to promote progression. However, the role of specific ion channel genes in Papillary Thyroid Carcinoma (PTC) and their clinical significance remains unclear. - Source: PubMed
Publication date: 2026/06/22
Liu XinyuMei ChengjinTan JifengLiu YanlanLiu YuyaoZhou ZhigangZhao Jianfu - While Wilms tumor (WT) is primarily associated with mutations in and genes, these alterations account for only ~30% of cases, suggesting a broader, unexplored genetic landscape. - Source: PubMed
Publication date: 2026/05/05
Kumar SourabhSharma JyotiPandey HimaniJain VisheshDhua Anjan KumarYadav Devendra KumarDivya GaliLal DeviGoel PrabudhAgarwala Sandeep - Meningioma is the most common central nervous system tumor and high-grade tumors frequently show progressive growth or recurrence, posing substantial therapeutic challenges. However, the lack of effective chemotherapy and targeted therapies contributes to poor prognoses in patients with high-grade disease. In this study, we evaluated KRT18 expression in meningiomas and examined its correlation with patient prognosis using RNA sequencing and immunofluorescence staining. The oncogenic role of KRT18 in high-grade meningioma was further investigated using IOMM-Lee and CH157-MN cells, xenograft mouse models, and paraffin-embedded meningioma tissue sections. Finally, small-molecule inhibitors targeting KRT18-related mechanisms were explored. Analysis of clinical specimens across different meningioma grades demonstrated that KRT18 overexpression is associated with more advanced clinical features and poorer prognosis. Functional studies showed that KRT18 promotes meningioma cell proliferation and facilitates cell cycle progression by activating the PI3K/AKT signaling pathway. Mechanistically, KRT18 interacted with LDHA, an upstream regulator of PI3K/AKT signaling, and enhanced LDHA stability via inhibition of ubiquitination, which drives oncogenic growth by activating glycolysis and the PI3K/AKT signaling pathway. These findings were corroborated in a xenograft model. Finally, Fluvastatin was identified as a novel inhibitor that specifically targets the interaction between KRT18 and LDHA, thereby inhibiting meningioma proliferation by suppressing glycolysis and PI3K/AKT signaling. Collectively, these findings indicate that KRT18 serves as a potential diagnostic, prognostic, aggressiveness-related, and potential grading biomarker. It also functions as an oncogene by activating glycolysis and the PI3K/AKT signaling pathway through interaction with LDHA. Additionally, Fluvastatin is identified as a candidate for drug repurposing in high-grade meningioma. - Source: PubMed
Publication date: 2026/06/15
Li HuaningShi RunGao YapengCheng XingWang ZhichaoGao YuShi ZhumeiGuo MengjieYou YongpingWang Xiefeng - Diabetic kidney disease (DKD) is a type of chronic renal injury induced by diabetes mellitus and is characterized by persistent proteinuria and progressive decreases in the glomerular filtration rate. Recent studies have highlighted the significance of histone lactylation and necroptosis in the pathogenesis of DKD. We explored the mechanisms by which lactate-induced histone H3 lysine-18 lactylation (H3K18la) and H3K27la promote necroptosis in DKD. Lactate-induced H3K18la and H3K27la modulated Fas transcription, contributing to necroptosis and DKD progression. Moreover, keratin 18 (KRT18), identified as a lactyltransferase, regulated H3K18la and H3K27la levels, subsequently inducing Fas transcription and necroptosis. Furthermore, ginsenoside Rc (gRc) inhibited KRT18 lactyltransferase activity by competing for the lactate binding site in KRT18. Notably, gRc treatment reduced the KRT18, H3K18la, H3K27la, and Fas levels and alleviated necroptosis and renal dysfunction in DKD models. In conclusion, KRT18 functions as a lactyltransferase to induce Fas transcription and necroptosis. Moreover, inhibiting KRT18-mediated histone lactylation via gRc is a potential strategy for treating DKD. - Source: PubMed
Publication date: 2026/06/12
Zhao QiaoLiu XuYang YangliangMeng FufenMeng ZhipengZhu Minmin - The luminal epithelium (LE) serves as the primary interface for embryo-maternal communication during implantation. In ruminants such as sheep, the LE orchestrates critical reproductive events, including noninvasive adhesion, conceptus elongation, and pregnancy recognition. However, existing models face significant limitations: conventional two-dimensional (2D) cultures fail to recapitulate endometrial complexity, while current organoid systems are predominantly derived from glandular epithelium. Herein, we report the establishment of a robust three-dimensional (3D) culture system for generating ovine endometrial luminal epithelial organoids using an optimized expansion medium (ExM) supplemented with CHIR99021, Y-27632, SB202190, and the EphrinA1 ligand. The resulting organoids exhibited characteristic luminal epithelium features, including polarized architecture, mucin secretion, and high expression of lineage markers (keratin 18 (KRT-18), trophoblast cell surface antigen 2 (TROP2), and epithelial cell adhesion molecule (EpCAM)). Moreover, we developed an apical-out polarity model that faithfully recapitulates the in vivo luminal orientation. Transcriptomic analysis confirmed the close resemblance between organoids and native luminal epithelium, as well as maintained hormonal responsiveness. Functional validation demonstrated the organoids' capacity to promote blastocyst expansion and trophoblast proliferation in co-culture systems, as well as substrate-specific adhesion that was enhanced by β-estradiol (E2) + medroxyprogesterone acetate (MPA) treatment. Notably, we identified erythropoietin-producing hepatocellular receptor A (EphA) signaling as a novel regulator of stemness properties during organoid development. The successful generation of functional luminal epithelial organoids thus provides a physiologically relevant model that mirrors native endometrial structure, hormone responses, and embryo interactions. As such, it offers a valuable platform for investigating the mechanisms of endometrial receptivity and for screening potential therapeutics aimed at improving reproductive efficiency in ruminants. - Source: PubMed
Publication date: 2026/06/09
Guo JiaheHuang XinaiXia RongxinGao QinYang HuaWang LiqinMai QingyangDeng MingtianZhang GuominZhang YanliWang Feng