ENPP2_BOVIN ENPP2 ELISA tesk kit
- Known as:
- ENPP2_BOVIN ENPP2 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15766
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- ENPP2_BOVIN ENPP2 ELISA tesk kit
Related genes to: ENPP2_BOVIN ENPP2 ELISA tesk kit
- Gene:
- ENPP2 NIH gene
- Name:
- ectonucleotide pyrophosphatase/phosphodiesterase 2
- Previous symbol:
- PDNP2
- Synonyms:
- ATX, PD-IALPHA
- Chromosome:
- 8q24.12
- Locus Type:
- gene with protein product
- Date approved:
- 1995-08-10
- Date modifiied:
- 2015-09-11
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- Phenolic endocrine-disrupting chemicals (EDCs) like nonylphenol (NP) and octylphenol (OP) are widespread water pollutants. Their estrogen-like properties are suspected contributors to prostate cancer, but their precise molecular mechanisms remain unclear. - Source: PubMed
Publication date: 2026/06/02
Zhu XinyaoWu QilongLi YuqiLiu ZhiyuZeng YangZeng ZhiqiangZhou YuboZou LunhongWu XiaochunZhao DanDeng QingfuZhou Tao - ENPP1 is emerging as a potential target for cancer immunotherapy due to its negatively regulatory effect on the STING pathway via hydrolysis of cGAMP. Herein, we report the identification and optimization of compound starting from hit compound . is a potent and selective ENPP1 inhibitor featuring a novel pyrrolo[1',2':1,6]pyrimido[5,4-]pyridazin-6(5)-one core scaffold. It exhibited substantial inhibitory activity against ENPP1 with an IC value of 9.5 nM, while showing weak inhibition against ENPP2/3. In the cGAMP-mediated STING pathway, this compound effectively enhanced the expression of downstream genes and promoted the phosphorylation of the relevant protein. Moreover, it displayed favorable pharmacokinetic properties and no evident cytotoxicity. In a 4T1 syngeneic mouse model, oral administration of compound demonstrated significant antitumor effects and enhanced the efficacy of both anti-PD-1 antibody and chemotherapy, with good tolerability. Collectively, these results highlight the potential of compound to potentiate STING-mediated antitumor immunity. - Source: PubMed
Publication date: 2026/05/26
Nong CuijieZhu MengyuanZheng WeilunYang JiachengWang HaidiLi ChuanghuiWen BojieLiu YuZhu XiaoyuZhu TaoXu YuHui HuiLai Yisheng - Hepatocellular carcinoma (HCC) shows substantial biological heterogeneity and commonly develops within an immunosuppressive microenvironment. Tumor-associated macrophages (TAMs), particularly M2-skewed subsets, are repeatedly associated with aggressive disease and may represent a biologically meaningful phenotype for biomarker development. Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) has been implicated in malignant behavior, but its linkage to TAM polarization and its potential as a laboratory-interpretable translational readout in HCC remain insufficiently clarified. ENPP2 expression was examined in paired HCC and adjacent tissues and referenced to public cohorts to provide clinical context. ENPP2 was overexpressed or silenced in HCC cells, followed by assays of proliferation, apoptosis, migration, and invasion. Macrophage polarization was evaluated using a noncontact Transwell coculture system with marker assessment and flow-cytometric readouts. Intracellular cyclic adenosine monophosphate (cAMP) was quantified, and forskolin was used to interrogate pathway involvement. Xenograft experiments were conducted to examine in vivo tumor growth. ENPP2 was upregulated in HCC and showed an association with unfavorable outcomes in public datasets. ENPP2 increased malignant phenotypes in HCC cells and shifted cocultured macrophages toward an M2-skewed state, whereas ENPP2 suppression produced the opposite pattern. ENPP2 modulation coincided with changes in intracellular cAMP signaling, and forskolin partially attenuated phenotypes observed after ENPP2 knockdown. These findings delineate a novel ENPP2/cAMP signaling axis that directly links tumor-intrinsic ENPP2 overexpression in HCC cells to the induction of M2-skewed TAM polarization, a mechanism that has not been previously characterized in HCC. This work not only identifies ENPP2 as a dual regulator of HCC cell malignancy and TAM polarization but also establishes cAMP as the critical intracellular mediator of this crosstalk, thereby strengthening the logical connection between these elements and advancing the understanding of HCC tumor-immune microenvironment interactions beyond existing literature. - Source: PubMed
Publication date: 2026/05/23
Chen ShiyiZheng JinliLong JianwuOu PengTong JianLin Fan - Choline is an essential nutrient required for the synthesis of key molecules, such as phosphatidylcholine, sphingomyelin, acetylcholine, and S-adenosylmethionine. Choline metabolism encompasses two phases, namely the postprandial and postabsorptive states. The former enables the digestion, absorption, distribution, and storage of choline derivatives after a meal, while the latter allows the cellular utilization of choline and the mobilization of stored choline-containing molecules during fasting. Understanding choline metabolism is fundamental to the study of lipid disorders such as steatohepatitis or atherosclerosis, as well as neurodegenerative diseases, including Alzheimer's disease, and inflammatory signaling pathways. Members of the alkaline phosphatase (AP) superfamily are prominent contributors to extracellular choline metabolism. Within this family, several APs and ectonucleotide pyrophosphatases/phosphodiesterases (ENPP) members are required for physiological choline metabolism. While intestinal alkaline phosphatase (IAP) and alkaline sphingomyelinase/ENPP7 both participate in the digestion of choline-containing derivatives in the gut during the postprandial phase, circulating ENPP2, ENPP6, and tissue-nonspecific alkaline phosphatase (TNAP) act during the postabsorptive phase to generate choline. In this review we first provide a comprehensive overview of choline metabolism and then describe how APs and ENPPs have functionally and structurally co-evolved to catalyze sequential reactions within this metabolic pathway. - Source: PubMed
Publication date: 2026/04/30
Lecornu FĂ©lixDrevet Mulard EvaBessueille LaurenceGerardin DaliaRautureau Gilles Jean PhilippeBallut LionelMagne David - Liver cirrhosis(LC) represents the end stage of chronic liver disease, yet reliable molecular markers remain limited. This study aimed to uncover potential diagnostic biomarkers and therapeutic targets for LC. - Source: PubMed
Publication date: 2026/03/14
Zhang KangChen TingJia ZhangyuZhao JunxiaHuang Na