GAST_RAT Gast ELISA tesk kit
- Known as:
- GAST_RAT Gast Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15715
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- GAST_RAT Gast ELISA tesk kit
Related genes to: GAST_RAT Gast ELISA tesk kit
- Gene:
- GAST NIH gene
- Name:
- gastrin
- Previous symbol:
- GAS
- Synonyms:
- -
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-08-25
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- Tuberculosis (TB) continues to be a major public health concern. Thus, identifying individuals at risk of progression to active disease is important for community health but remains difficult. To address this issue, we analysed plasma proteomic data from the UK Biobank to investigate host protein signatures associated with TB. The size of the prospective cohort (~ 500,000) combined with deep proteomic analysis (2,920 plasma proteins) allowed us to perform analysis on 42 individuals diagnosed with TB either before or after sampling, alongside matched controls with no history of TB. Using this approach, we identified significantly differentially expressed proteins (e.g. CDCP1, GAST) in individuals affected by TB, suggesting proteomics alternations that precede clinical onset and persist years after diagnosis. Functional annotation of significant proteins indicated involvement of immune and signalling pathways associated with chronic inflammatory responses and host defence mechanisms. These findings help advance the understanding of TB pathology and offer the potential for use of specific plasma proteins in the development of point of care risk assessment and diagnostic tools. - Source: PubMed
Publication date: 2026/06/06
Koziar NataliaWhetton Anthony DGeifman Nophar - Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of the CFTR protein encoded by certain CF-causing gene mutations. Amongst these, the triple combination therapy elexacaftor-tezacaftor-ivacaftor (ETI) has been the most impactful and widely used to date. Given chronic respiratory infection and concomitant inflammation is the leading cause of morbidity and early mortality for the majority in CF, what is not certain are the long-term effects of ETI therapy on the respiratory microbiota and pathogens embedded within. Here, we assessed the effects of ETI CFTRmt over 3 years on the respiratory microbiota, using sputum and cough swab samples, from a multi-centre cohort of 276 adults with CF (awCF) from 6 CF centres in the UK, USA, and Canada, and compared to a non-CF healthy cohort. - Source: PubMed
Publication date: 2026/05/30
Gavillet HelenHatfield Lauren RHardman MichelleMarsh RyanEinarsson Gisli GThornton Christina SParkins Michael DDuckers JamieBomberger Jennifer MHilliam YasminLee Stella ELord Robert WJones AndrewHorsley AlexanderDaniels Thomas W VTeneback Charlotte CRivett Damian Wvan der Gast Christopher - Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults and remains associated with marked heterogeneity and poor prognosis. To identify prognostic biomarkers and characterize their cellular contexts, we integrated public proteomic and single-nucleus transcriptomic datasets. Protein expression data from the TCPA GBM cohort were used to construct a prognostic model by univariate and multivariable Cox regression analyses, followed by Kaplan-Meier survival, time-dependent ROC, and nomogram analyses. Single-nucleus RNA-seq data from GSE138794 were used to define the cellular distribution of model proteins and to perform marker-centered functional analyses. A four-protein signature consisting of BCL2, CTNNB1, CHEK2, and NDRG1_pT346 was established. The derived risk score significantly stratified patients into high- and low-risk groups with distinct overall survival and progression-free survival outcomes, and remained independently associated with prognosis after adjustment for clinical covariates. In the single-cell atlas, inferCNV-guided refinement identified malignant glioma cells and further resolved them into Glioma_MES, Glioma_PN, and Glioma_CL states. The four prognostic markers showed distinct cellular preferences: BCL2 and NDRG1 were mainly enriched in oligodendroglial-related populations and selected glioma states, whereas CHEK2 and CTNNB1 were more highly expressed in myeloid-associated populations. Among the four markers, only CHEK2- and NDRG1-defined malignant glioma subgroups showed sufficient transcriptional divergence for downstream analysis. CHEK2-positive glioma cells were enriched for DNA replication, chromosome segregation, DNA damage response, and checkpoint-related programs, whereas NDRG1-positive glioma cells were characterized by hypoxia response, glycolysis, and metabolic adaptation. CellChat analysis further revealed distinct communication patterns for CHEK2- and NDRG1-associated malignant glioma cells. - Source: PubMed
Publication date: 2026/05/30
Yang ChengyongLuo JunchiYang ShaDeng MeiXiong TaoZhang JunhengYang WenjingZhang JiqinXiang XinChu LiangzhaoTan Ying - Interconnected cave-fracture networks are widely developed in karst regions. The complex geometric characteristics and strong heterogeneity of these formations not only disturb groundwater flow fields but also alter the in-situ stress state of the surrounding rock, leading to the formation of irregular preferential seepage pathways. These factors pose significant challenges to the long-term stability and construction safety of underground tunnels. In this study, a hydro-mechanical (HM) coupled model is established using COMSOL Multiphysics to investigate the seepage behavior of tunnels under different geological conditions, considering the synergistic effects of cave-fracture systems. The model is validated against classical consolidation problems and fracture seepage cases, and the results show good agreement with analytical solutions and previous studies, indicating its reliability. The results show that increasing fracture density enhances network connectivity, resulting in higher seepage pressure on the tunnel lining accompanied by greater non-uniformity. In addition, larger cave radius, shorter cave distance, and higher cave pressure further increase the seepage pressure on the lining, with caves located above the tunnel exerting a more pronounced influence on the upper section. When a connected seepage pathway forms between the cave, fractures, and lining, the local seepage pressure is more likely to exceed the lining bearing capacity. These findings suggest that targeted anti-seepage measures, such as grouting reinforcement, are necessary in high-risk zones, and provide a basis for the adaptive design of tunnel linings in karst regions. - Source: PubMed
Publication date: 2026/05/25
Li GuipingTao JianShen ZhiyongWang JunDai WeiZheng Yantao - Clinical clerkships are essential in medical education, but ethical and legal restrictions limit the invasive procedures performed by medical students in Japan. The 2023 revision of the Medical Practitioners' Act permits students to conduct supervised procedures, such as venous blood collection and ultrasound examinations, after passing certain exams. This study investigates the public acceptance of these procedures, identifies barriers, and explores strategies to enhance medical student education patient-student collaboration. - Source: PubMed
Publication date: 2026/05/21
Okada ErikoNawa NobutoshiYoshida ShokoAkaishi YuKashimada AyakoYamawaki Masanaga