CMGA_PIG CHGA ELISA tesk kit
- Known as:
- CMGA_PIG CHGA Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15614
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- CMGA_PIG CHGA ELISA tesk kit
Related genes to: CMGA_PIG CHGA ELISA tesk kit
- Gene:
- CHGA NIH gene
- Name:
- chromogranin A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q32.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
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- Taurine supplementation has been shown to promote growth, but the underlying mechanisms remain incompletely understood. Here, we investigated the effects of taurine on intestinal health in mice under both normal and LPS-induced inflammatory conditions. Thirty-six male C57BL/6J mice were first divided into control and 2% taurine groups for 42 days. On day 43, each group was split into PBS or LPS subgroups, resulting in four groups (Con, LPS, Tau, LPS+Tau). Twelve hours after LPS injection, all mice were euthanized for sample collection. The results demonstrated that taurine supplementation increased body weight gain ( < 0.05) without affecting feed intake, indicating improved feed efficiency. Mechanistically, taurine supplementation enhanced intestinal absorptive function through multiple convergent pathways: it increased the activities of digestive enzymes (trypsin, maltase, and sucrase), upregulated nutrient transporter gene expression (, , and ), and improved villus and microvillus morphology. These functional improvements were confirmed by a 1.7-fold increase in serum D-xylose absorption and significant elevations in total protein and albumin levels ( < 0.05). Notably, taurine supplementation upregulated the gene expression of intestinal stem cell (ISC) proliferation markers ( and ) and differentiation markers, including (enterocyte), (goblet cell) and (enteroendocrine cell). Under LPS challenge, taurine supplementation significantly attenuated disease severity, preserved villus architecture, and reversed inflammation-induced declines in digestive enzymes and nutrient transporters. Collectively, these findings establish taurine as a multifunctional nutrient that enhances intestinal health by optimizing digestive and absorptive capacity while promoting epithelial renewal, thereby supporting its potential application to improve growth and counteract intestinal injury. - Source: PubMed
Publication date: 2026/05/14
Kong JingxiaChen JianjunHan YuZhang YuhuiJiang ShouchuanDu Huahua - Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer. This study aimed to elucidate the involvement of genes associated with 25 cell-death modalities in HCC development and progression. HCC transcriptomic datasets were integrated with curated cell death-related genes. Candidate genes were screened by differential expression analysis and protein-protein interaction network construction. Prognostic genes were identified using univariate Cox regression, proportional hazards assumption testing, and stepwise multivariate Cox regression. A risk score model and a nomogram were established, followed by risk stratification and analyses of immune infiltration, immune checkpoints, somatic mutations, and in silico drug sensitivity. Single-cell RNA sequencing was used to identify key cell types, infer temporal dynamics, and characterize intercellular communication, and findings were validated by quantitative real-time PCR (qRT-PCR). MAPT, CDKN2A, NQO1, CHGA, SERPINE1, and RET were identified as prognostic genes, and the risk model and nomogram showed good prognostic performance. Immune profiling revealed significant differences in multiple immune cell subsets between risk groups, including activated CD4+ T cells. Notably, CDKN2A correlated with activated CD4+ T cells, NQO1 with natural killer cells, RET with CD4+ central memory cells, and SERPINE1 with activated dendritic cells; RET also showed the strongest positive correlation with HAVCR2. Mutation spectra differed across risk groups, and ten drugs displayed significant predicted IC50 differences; all six genes were negatively correlated with KIN001.135. Single-cell analyses highlighted hepatocytes as a key cell type with strong hepatocyte-epithelial communication. qRT-PCR confirmed higher MAPT, CDKN2A, NQO1, and SERPINE1 expression in HCC tissues than in normal tissues. - Source: PubMed
Publication date: 2026/04/22
Wu WeiWang YingjiZhao XiaochengDong KeLi MaodeAn XiangXu YingyanWang ShuaiLi Dexin - Type 1 diabetes is an autoimmune disease marked by the destruction of beta cells in pancreatic islets, with an incomplete picture of disease progression and a lack of a definitive cure. A recent finding linked pancreatic ductal cells of type 1 diabetic donors with elevated levels of human leukocyte antigen (HLA) class II molecules; however, the causal relationship and functional significance of this finding remain unknown. Because HLA class II molecules are typically expressed by professional antigen-presenting cells (APCs), this raises the possibility of ductal cells functioning as non-professional APCs. In this study, we test the hypothesis that ductal cells are responsive to type 1 diabetes-associated proinflammatory cytokines, TNF-α, IL-1β and IFN-γ, and can act as non-professional APCs. - Source: PubMed
Publication date: 2026/05/07
Erdem NeslihanArribas-Layton DavidZook Heather NO'Meally DenisMares JacobQuijano Janine CDonohue CecileOrtiz Jose AJou KevinVasavada Rupangi CMontero EnriqueKaddis John SReijonen HelenaKu Hsun Teresa - Ectopic ACTH-secreting pheochromocytomas are rare and life-threatening endocrine tumors responsible for hypertension, paroxysmal symptoms, and Cushing's syndrome. The cellular origin of ACTH and the tumor's molecular characteristics remain poorly understood. Single-cell RNA sequencing was performed on tumor specimens and adjacent adrenal tissues from three patients with ectopic ACTH-secreting pheochromocytomas. Integrated bioinformatic analyses, including differential expression, functional enrichment, cell-cell communication, and pseudotemporal trajectory inference, were conducted. Key findings were supported by immunofluorescence and immunohistochemical staining. Our study integrated single-cell transcriptomic profiling with detailed clinical characterization of three cases of ectopic ACTH-secreting pheochromocytomas. All patients presented classic Cushing's features and variable catecholamine secretory patterns. Hormone levels improved after surgical resection. Single-cell analysis revealed a complex tumor microenvironment comprising 11 distinct cell populations. Chromaffin cells expressing the ACTH precursor gene POMC were identified within the tumor cell population, suggesting that these cells may represent the source of ectopic ACTH production. This finding was further supported by immunofluorescence and immunohistochemical staining demonstrating ACTH expression in CHGA-positive chromaffin tumor cells and absence of staining for the adrenocortical marker α-inhibin. These tumor cells exhibited metabolic reprogramming characterized by upregulation of oxidative phosphorylation pathways and downregulation of adaptive immune responses. Cell-cell communication analysis suggested interactions between POMC-expressing chromaffin cells and cytotoxic immune cells. Pseudotemporal trajectory analysis further suggested that these chromaffin cells did not transition toward a steroidogenic fate. This study provided a single-cell atlas of ectopic ACTH-secreting pheochromocytomas. Our integrated analysis suggested POMC-expressing chromaffin cells may represent the cellular source of ectopic ACTH production and revealed a transcriptional signature involving metabolic activation and immune modulation that might contribute to tumor progression. These findings offered new insights into the pathophysiology of this rare disease and provided a framework for future investigations into the molecular mechanisms underlying ectopic ACTH production. - Source: PubMed
Publication date: 2026/04/18
Wang XuLian PenghuZheng GuoyangWang WendaZhao YangZhang Yushi - : Globally, colorectal cancer ranks third in causing 900,000 deaths annually. Some patients undergoing chemotherapy develop resistance, leading to metastasis. We investigated CHGA and UCHL1 proteins correlate with lymph node metastasis (J Cell Mol Med. 2023;27:2004-2020). This study aimed to analyze the relationship of CHGA and UCHL1 with the epithelial-mesenchymal transition (EMT) and the Rho/ERK/NFκB signaling pathway in OXA-resistant CRC cells. - Source: PubMed
Publication date: 2026/02/26
Lee Ko-ChaoCheng Kung-ChuanHuang Cheng-YiHsieh Meng-ChiaoTung Shui-YiHsieh Yung-YuLee Kam-FaiTeng Chih-ChuanKuo Hsing-Chun