CMGA_HUMAN CHGA ELISA tesk kit
- Known as:
- CMGA_HUMAN CHGA Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15606
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- CMGA_HUMAN CHGA ELISA tesk kit
Related genes to: CMGA_HUMAN CHGA ELISA tesk kit
- Gene:
- CHGA NIH gene
- Name:
- chromogranin A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q32.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: CMGA_HUMAN CHGA ELISA tesk kit
Related articles to: CMGA_HUMAN CHGA ELISA tesk kit
- Frailty is a well-established clinical risk factor for dementia, but its underlying mechanisms remain poorly defined. We aimed to investigate whether proteomic signatures and individual proteins linked to frailty could predict and characterize the association between frailty and dementia. - Source: PubMed
Publication date: 2026/07/17
Zhang XiruHuang QingmeiHuang JielinZhang PeidongFeng XinLi ZhihaoRaper Daniel M SMao Chen - The gastric endocrine population comprises functionally distinct cell types that exhibit both neuronal and endocrine characteristics; however, their molecular markers remain incompletely defined. Here, we identify growth differentiation factor 9 (GDF9), nephrin (NPHS1), and rearranged during transfection (RET) as novel markers of gastric endocrine cells. A co-immunofluorescence (IF) analysis demonstrated that GDF9, NPHS1, and RET are co-expressed with chromogranin A (CHGA), a well-known marker of gastrointestinal endocrine cells. Further Co-IF analysis revealed that GDF9-expressing cells were negative for ghrelin and somatostatin, whereas NPHS1 was co-expressed with both hormones. A subpopulation of RET-positive cells co-expressed ghrelin but not somatostatin. Notably, GDF9- and RET-positive cells co-expressed dopamine decarboxylase (DDC), consistent with enrichment in enterochromaffin-like (ECL) cells. Revisitation of our previous mRNA-sequencing data revealed reduced transcript levels of , , and in CA-PKA mice, which express constitutively active protein kinase A (PKA) and develop gastric preneoplastic lesions. Co-IF and cellular quantification showed a localized reduction in the density of GDF9 and CHGA-positive endocrine cells, together with altered abundance of NPHS1- and RET-expressing cells in CA-PKA stomachs. These changes occurred in the context of extensive hyperplasia of the surrounding epithelium, indicating that the observed alterations reflect localized reduction and non-cell-autonomous effects of epithelial expansion. Notably, we observed RET misexpression outside the endocrine compartment in CA-PKA mice, suggesting that aberrant RET signaling may contribute to lesions by promoting abnormal glandular branching. Together, these findings identify GDF9, NPHS1, and RET as novel markers of gastric endocrine cells and their potential role in gastric homeostasis. - Source: PubMed
Publication date: 2026/06/23
Alnahrawy EsraaAbate FentahunHayden KarlPuri Pawan - Gait patterns in children with myelomeningocele (MMC) at various neurological levels have been described, both with and without orthotic support. Although the neurological level of the lesion serves as an important predictor of ambulatory potential, the expected walking ability is not always achieved, as additional factors such as spasticity may influence gait negatively. The aim of this study was to retrospectively compare gait patterns as assessed in childhood with those observed in adulthood. - Source: PubMed
Publication date: 2026/06/23
Eriksson MarieGutierrez-Farewik Elena MBartonek Åsa - Enterotoxigenic Escherichia coli (ETEC) is the main pathogen causing bacterial diarrhea in piglets. Ningxiang piglets (native Chinese breed) has the characteristics of stress resistance and low diarrhea rate, which is closely related to the intestinal microbial structure shaped by its high fiber feed. Our study found that Parabacteroides distasonis (P. distasonis), a representative intestinal bacterial species in Ningxiang piglets, had a positive correlation with fecal secretory immunoglobulin A (sIgA). P. distasonis strain was isolated from Ningxiang piglets and verified the regulation on intestinal injury induced by ETEC in piglets. Results showed P. distasonis could alleviate the weight loss of piglets caused by ETEC infection. P. distasonis significantly decreased the diarrhea rate and inhibited the colonization of ETEC in intestinal mucosa, while decreased the ileal mucosal IL-1β, IL-6 and TNF-α levels after ETEC infection (P < 0.05). P. distasonis decreased the serum DAO activity, D-lactate and Endotoxin and upregulating the expression of small intestine mucosal sIgA. P. distasonis enhanced the expression of tight junction proteins, including claudin-1, claudin-3, occludin, and zonula occludens-1 (ZO-1), at both the transcriptional and translational levels (P < 0.05). It also upregulates the expression of intestinal epithelial proliferation markers including PCNA, β-catenin, CHGA, Lgr5 and LYZ (P < 0.05). Furthermore, P. distasonis affected the microbial structure and increased the relative abundances of beneficial genera, as well as increased the SCFAs contents in ileum of ETEC-challenged piglets. Taken together, P. distasonis could maintain the integrity of intestinal epithelial barrier, alleviate intestinal inflammation and repair intestinal barrier damage caused by ETEC, which provides theoretical basis for nutritional intervention of diarrhea in piglets. - Source: PubMed
Publication date: 2026/06/18
Wu ZichenZhang LonglinLi HongkunZhang ZihaoTan BieWang Jing - Recent advances in genetic analysis have led to further subtyping of small-cell lung carcinoma (SCLC). The major subtypes of SCLC are the ASCL1-predominant (SCLC-A), NEUROD1-predominant (SCLC-N), and POU2F3 (SCLC-P) subtypes. SCLC-A and SCLC-N tumors express chromogranin A (CHGA) and synaptophysin (SYP), but SCLC-P tumors do not. Large-cell neuroendocrine carcinoma, another type of neuroendocrine carcinoma (NEC), also frequently expresses CHGA and SYP. Because CHGA and SYP expression is controlled by a transrepressor, repressor element 1-silencing transcription factor (REST), the mechanisms underlying REST suppression in NEC were investigated, with a focus on miRNAs and epigenetics, to determine the causes of the differences in the expression of CHGA and SYP between SCLC-A/N and SCLC-P cells. The results showed that miR-375-3p, which was induced by ASCL1 and NEUROD1, repressed REST expression by binding to the 3'-untranslated region of REST mRNA. Bisulfite sequencing and experiments using a DNA methyltransferase inhibitor, a histone deacetylase inhibitor, and chromatin immunoprecipitation-based quantitative PCR revealed that promoter/enhancer hypermethylation and histone deacetylation causes REST gene inactivation in SCLC-A/N. These phenomena were also observed in a large-cell neuroendocrine carcinoma cell line that expressed high levels of ASCL1 and NEUROD1. Taken together, these findings suggest that NEC has dual repressive effects on REST expression, resulting in strict regulation of the expression of CHGA, SYP, and other REST-controlled neuronal/neuroendocrine-specific genes. - Source: PubMed
Publication date: 2026/06/18
Konno KoudaiSato-Yazawa HanakoIshii JunKashiwagi KorehitoIwamoto MasamiMiyazawa TadasukeKohno KakeruOnozaki MasatoNoda ShuheiMiyata-Hiramatsu ChieShimoyamada HiroakiYazawa Takuya