Rat TNF_alpha 10 ug
- Known as:
- Rat TNF_alpha 10 ug
- Catalog number:
- 1052-10
- Product Quantity:
- 10 ug
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- Rat TNF_alpha 10
Related products to: Rat TNF_alpha 10 ug
Related articles to: Rat TNF_alpha 10 ug
- Myocardial infarction (MI) remains the leading cause of death worldwide. We previously found that a specific population of human fetal cardiac fibroblasts (fCFs), which express vascular cell adhesion molecule 1 (VCAM1), have cardioprotective effects after MI, inducing reparative cardiac lymphangiogenesis. This study investigated whether adult cardiac fibroblasts (aCFs), which are more feasible for autologous transplantation, differ in surface marker expression and lymphangiogenic potential compared to fCFs. Furthermore, we examined whether aCFs could be exogenously manipulated to acquire fCF-like lymphangiogenic potential and serve as a cell therapy for MI and MI-associated heart failure. In vivo MI models (rat and mouse) and in vitro coculture assays with lymphatic endothelial cells were conducted. We found that TNF-α and IL-4 stimulation induced aCFs to express VCAM1 via NF-κB and STAT6 signaling, yielding a subpopulation termed adult VCAM1 cardiac fibroblasts (aVCFs). These aVCFs, distinct from myofibroblasts, expressed CD90 and improved cardiac function post-MI. Adrenomedullin (ADM) was identified as a key paracrine effector, and its knockdown attenuated the pro-lymphangiogenic and cardioprotective effects of aVCFs. Our findings demonstrate that aVCFs promote cardiac lymphangiogenesis and protect cardiac function following MI, highlighting their potential as an autologous cell therapy. - Source: PubMed
Publication date: 2025/09/16
Matsuoka YuimiShimizu YuukiLuo HaihangSegard Bertrand-DavidMatsuyama MakotoHayashi TakumiMurohara ToyoakiIwamiya Takahiro - This study aims to investigate the protective effects and mechanisms of 20S-protopanaxadiol (PPD), a key component derived from ginseng folium, against diabetic nephropathy (DN). - Source: PubMed
Publication date: 2025/09/16
Li ChenfeiMa ChifaZhao RuxuanLi XinfengYu HengchiYuan Mingxia - This research investigates the therapeutic potential of betulinic acid (BA) in colorectal cancer (CRC), focusing on its effects on apoptosis, inflammation, and oxidative stress markers. HT29 colorectal cancer cells were exposed to various concentrations of BA. Immunohistochemistry using Anti-Bax and Anti-Bcl-2 antibodies, as well as ELISA assays, were employed to assess levels of markers such as TNF-α, TGF-β, IL-1β, IL-6, IL-10, SOD, and CAT. Results revealed that higher doses of BA (e.g. 50 and 100 μg/mL) significantly upregulated TGF-β, IL-10, SOD, and CAT levels, while downregulating pro-inflammatory markers like TNF-α, IL-1β, and IL-6. Histological analysis confirmed that BA promoted apoptosis, with distinct expression patterns of Bax and Bcl-2. These findings suggest that BA may serve as a promising natural therapeutic agent for colorectal cancer, though further studies are needed to elucidate its molecular mechanisms and cellular targets. - Source: PubMed
Publication date: 2025/09/16
Aksak Karamese SelinaBayram PinarUzuner Muhammet Bora - Shilajit, a natural product utilized in traditional Tibetan medicine and known in China as ZhaXun (ZX), has been historically used for treating liver disorders. Recent studies have indicated that bioactive components in ZX, such as humic acid, fulvic acid, and isorhamnetin, exhibit anti-inflammatory, antioxidant, and immunomodulatory activities. These properties suggest its potential therapeutic relevance in alleviating acetaminophen (APAP)-induced acute liver injury (ALI). - Source: PubMed
Publication date: 2025/09/14
He Shi-QiYang Si-YanLi YuanDing RongZhang Jie-LinZhong Shi-HongGu Rui - Twelve previously undescribed compounds, named coelotrinins A-L (1-12), comprising eight dihydrophenanthrene derivatives (1, 4-5, and 7-11), two phenanthrene derivatives (2-3), and two phenanthrene-dihydrophenanthrene derivatives (6 and 12), along with 21 known compounds (13-33), were isolated from the pseudobulbs of Coelogyne trinervis. The structures were elucidated via spectroscopic data analysis, and their configurations were determined by optical rotation values and by comparing experimental and calculated electronic circular dichroism curves. Among these compounds, four compounds 1, 16, 23, and 24 showed immunomodulatory effects by inhibiting LPS-induced TNF-α production in THP-1 monocytes. Only coelotrinin A (1) exhibited an immunomodulatory effect with suppression on human peripheral blood mononuclear cells isolated from patients with multiple sclerosis. - Source: PubMed
Publication date: 2025/09/14
Pengdee ChattarikaDehlinger AdelineThant May ThazinNaini Al ArofatusFajriah SofaPunpreuk YanyongMekboonsonglarp WanwimonKongkatitham VirunhJungsuttiwong SiripornChaotham ChatchaiBöttcher ChotimaSritularak Boonchoo