TXNIP_PIG TXNIP ELISA tesk kit
- Known as:
- TXNIP_PIG TXNIP Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen15150
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- TXNIP_PIG TXNIP ELISA tesk kit
Related genes to: TXNIP_PIG TXNIP ELISA tesk kit
- Gene:
- TXNIP NIH gene
- Name:
- thioredoxin interacting protein
- Previous symbol:
- -
- Synonyms:
- VDUP1, EST01027, HHCPA78, THIF, ARRDC6
- Chromosome:
- 1q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-12-12
- Date modifiied:
- 2016-10-05
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- - Source: PubMed
Publication date: 2026/06/01
Civati CelineSegers Vincent F M - Sepsis-associated liver injury (SALI) is a risk factor for high mortality in patients with sepsis. However, the pathological mechanism and treatment strategies of SALI remain unclear. This study aims to explore the influence of lncRNA MIAT expression on SALI. - Source: PubMed
Publication date: 2026/05/30
Shi JuanjuanLiu ZhiyuanLiu JuanShi Enming - Sarcopenia is an age-related syndrome characterized by progressive loss of skeletal muscle mass, strength, and function, and represents a major challenge to healthy aging. Thioredoxin-interacting protein (TXNIP) has been associated with skeletal muscle alterations in sarcopenia, but its potential role in exercise-related adaptation remains unclear. In this study, naturally aged male Sprague-Dawley rats underwent a 10-week treadmill exercise intervention, and gastrocnemius muscle was examined using morphological, functional, and molecular approaches. Aging was associated with reduced relative gastrocnemius muscle mass, smaller myofiber cross-sectional area, impaired grip strength and endurance capacity, increased Atrogin-1 and MuRF-1 expression, enhanced apoptosis- and inflammation-related signaling, reduced Trx expression, increased TXNIP protein expression, detectable TXNIP-Trx and TXNIP-NLRP3 interactions, and altered autophagy-related markers. Aerobic exercise improved muscle morphology and endurance-related performance in aged rats, and was accompanied by reduced Atrogin-1 and MuRF-1 expression, coordinated changes in apoptosis-, inflammation-, and autophagy-related markers, reduced TXNIP expression at both mRNA and protein levels, decreased TXNIP-Trx and TXNIP-NLRP3 interactions, and altered PI3K/Akt/mTOR-related protein phosphorylation. These findings suggest that aerobic exercise may attenuate sarcopenia-related changes in aged skeletal muscle, potentially in association with TXNIP-related multi-pathway regulation. - Source: PubMed
Publication date: 2026/05/29
Zhao XiaoqinChen QianyuYou JiaqiAn ZhenxianLi JunpingYu LiangXu Zujie - To investigate whether catalpol protects against diabetic retinal vascular endothelial injury by targeting the methyltransferase-like 3 (METTL3)-mA-thioredoxin-interacting protein (TXNIP) axis and inhibiting nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation. - Source: PubMed
Publication date: 2026/06/18
Liu Jing-YuZhu Jun-YaXiao Yi-FangGe Yi-RuiYan FengJiang Qin - To investigate the expression of thioredoxin interacting protein（TXNIP）/nod like receptor thermoprotein domain related protein 3（NLRP3） signaling pathway in nasal polyps of patients with chronic sinusitis with nasal polyps（CRSwNP）, and to analyze its predictive value for postoperative recurrence. A prospective study was conducted on 130 patients with CRSwNP who underwent endoscopic sinus surgery at Wenzhou People's Hospital from January 2019 to January 2024. These patients were divided into a recurrence group and a non-recurrence group based on the recurrence status within one year after surgery. The clinical data and the expression of TXNIP, NLRP3 mRNA, and protein in nasal polyp tissues were compared between the two groups. The impact of TXNIP and NLRP3 expression on postoperative recurrence was analyzed. The interaction between TXNIP and NLRP3 expression in postoperative recurrence was also analyzed. The predictive value of TXNIP and NLRP3 expression for postoperative recurrence was evaluated. The recurrence group had a higher proportion of eosinophilic（EOS） nasal polyps, postoperative infection, allergic rhinitis, preoperative Lund-Mackay score, and sinus CT score, as well as higher levels of serum interleukin-5（IL-5） and interleukin-21（IL-21） than those in the non-recurrence group（<0.05）. The expression levels of TXNIP and NLRP3 mRNA and protein in nasal polyps from the recurrence group were also higher than those from the non-recurrence group（<0.05）. After adjusting for EOS nasal polyps, postoperative infection, preoperative Lund-Mackay score, and serum IL-5 and IL-21 levels, the expression of TXNIP and NLRP3 proteins in nasal polyps remained independent risk factors for postoperative recurrence（<0.05）. High levels of TXNIP and High levels of NLRP3 showed a positive interaction in the risk of postoperative recurrence（<0.05）. A conventional prediction model was constructed based on EOS nasal polyps, postoperative infection, preoperative Lund-Mackay score, and serum IL-5 and IL-21 levels. A novel prediction model was constructed based on these factors as well as the expression of TXNIP and NLRP3 proteins in nasal polyps. The AUC value of the novel prediction model for predicting postoperative recurrence was significantly higher than that of the conventional model（<0.05）. The expression levels of TXNIP and NLRP3 in nasal polyps of patients with postoperative recurrence of CRSwNP are increased. High levels of TXNIP and high levels of NLRP3 have a positive interaction in the risk of postoperative recurrence. Detection of their levels has a certain predictive value for postoperative recurrence, and TXNIP and NLRP3 have a significant gain value in the construction of the prediction model of postoperative recurrence in patients with CRSwNP. - Source: PubMed
Lin XizeZhang YuLin Renyu