CD8A_HUMAN CD8A ELISA tesk kit
- Known as:
- CD8A_HUMAN CD8A Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen13470
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- Other suppliers
- Gene target:
- CD8A_HUMAN CD8A ELISA tesk kit
Related genes to: CD8A_HUMAN CD8A ELISA tesk kit
- Gene:
- CD8A NIH gene
- Name:
- CD8a molecule
- Previous symbol:
- CD8
- Synonyms:
- -
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CD8A_HUMAN CD8A ELISA tesk kit
Related articles to: CD8A_HUMAN CD8A ELISA tesk kit
- Double-negative T cells (DNTs; CD3CD4CD8) have been implicated in immune regulation in autoimmune settings, but their relevance to reproductive tissue immune balance and inflammation-associated infertility remains unclear. Here, we define a population of TCRβNK1.1 DNTs enriched in the mouse ovary and uterus and profiled its phenotype, tissue behavior, and function in inflammatory models associated with impaired fertility. In parallel, we performed RNA-seq on spleen- and thymus-derived NK1.1 DNT and CD8 T cell enriched population. Relative to CD8 T cells, peripheral NK1.1 DN T-cell-enriched populations displayed an activated, regulatory-like transcriptional profile with reduced Cd8a/Cd8b1, Il7r, and cytotoxic effector markers, alongside increased expression of Pdcd1, Lag3, Tox, and Il10. Ex vivo, FACS-sorted splenic DNTs produced low inflammatory cytokine output after CD3/CD28 stimulation and suppressed CD8 T-cell proliferation primarily through contact-dependent mechanisms. In vivo, ovarian DNTs decreased following CD8-targeting depletion, and ovarian and uterine DNTs showed limited exchange in parabiosis. In chronic interferon-γ-driven inflammation (ARE) and zona pellucida 3-induced ovarian inflammation, reproductive tissues exhibited reduced DNT frequencies, a shift in the DNT: CD8T ratio favoring CD8 T cells and increased activated CD8 phenotypes. Finally, adoptive transfer of ex vivo FACS-sorted wild-type DNTs into ARE females increased pregnancy frequency, supporting DNT-associated immunoregulation as a feature of inflammation-associated infertility. - Source: PubMed
Publication date: 2026/06/21
Bafor Enitome EMartin ToniTatematsu Bruna KarolineBettencourt Ian AKimmel Adrienne ESojka Dorothy KYoung Howard A - Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignancy with a poor prognosis. Finding early diagnosis and therapeutic targets for CCA is of great importance. The aim of this study was to screen for key genes involved in CCA using bioinformatics analysis, identify establishment of sister chromatid cohesion N-acetyltransferase 2 () as a core candidate, and validate its role experimentally. - Source: PubMed
Publication date: 2026/04/23
Fan LeJiang YongHu JingXiao FengChai YunxiaYi BinQiu Yinghe - Triple-negative breast cancer (TNBC) is an aggressive subtype often resistant to neoadjuvant chemotherapy (NAC), and tumor-infiltrating lymphocytes (TILs) are important predictors of response. Using single-cell RNA sequencing datasets of pre-treated TNBC tumors, we identified an 80-gene TIL-specific signature that captures immune activation and stratifies tumors by TIL abundance. Pathway analysis showed enrichment of immune-regulatory programs, including allograft rejection, consistent with adaptive immune activity. Validation across single-cell and bulk datasets linked the signature to favorable response and relapse-free survival. A multi-stage feature selection pipeline refined the panel to 30 genes, achieving strong prediction of pathological complete response versus residual disease across eleven independent TNBC cohorts ( = 680; mean area under the ROC curve [AUROC] = 0.77). Network analysis identified consensus hub genes, including , , and , central to T cell signaling. Regulatory analysis revealed a conserved set of TIL-associated transcription factors, supporting an immune program with clinical utility in TNBC stratification and therapeutic targeting strategies. - Source: PubMed
Publication date: 2026/06/08
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He RenkeLiu YuhanXiao RuiLin YuqiZhang NiLiu ZhiqiangLi QianqianChen Xuyi - Immune checkpoint inhibitors (ICI) are used to treat unresectable advanced or recurrent gastric cancer; however, reliable predictive biomarkers remain limited. This study aimed to identify biomarkers for predicting ICI efficacy using two independent cohorts. - Source: PubMed
Publication date: 2026/06/09
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