STAT3
- Known as:
- STAT3
- Catalog number:
- RP17131630002
- Product Quantity:
- 2 µg
- Category:
- -
- Supplier:
- Biovend
- Gene target:
- STAT3
Related genes to: STAT3
- Gene:
- STAT3 NIH gene
- Name:
- signal transducer and activator of transcription 3
- Previous symbol:
- -
- Synonyms:
- APRF
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2019-04-23
Related products to: STAT3
Acpin1,Acrosomal protein ACPIN1,Mouse,Mus musculus,Sipar,STAT3-interacting protein as a repressorAnserine Signal Transducer And Activator Of Transcription 3 Elisa Kit (STAT3)Anserine anti - Signal Transducer And Activator Of Transcription 3 Elisa Kit (STAT3)Anti- STAT3 (Ab-705) AntibodyAnti- STAT3 (Ab-705) AntibodyAnti- STAT3 (Ab-727) AntibodyAnti- STAT3 (Ab-727) AntibodyAnti- STAT3 (Phospho-Ser727) AntibodyAnti- STAT3 (Phospho-Ser727) AntibodyAnti- STAT3 (Phospho-Tyr705) AntibodyAnti- STAT3 (Phospho-Tyr705) AntibodyAnti-Human STAT3, Rabbit PolyclonalAnti-Human STAT3, Rabbit Polyclonal affinity purified IgGanti-n STAT3 , Rabbit polyclonal to n STAT3 , Isotype IgG, Host RabbitAnti-phospho-STAT3 (pTyr705<_SUP>) produced in rabbit Antibody Related articles to: STAT3
- To examine effects of naturally occurring antioxidants on DNA damage repair acute responses of ionizing radiation sustained by interventional physicians during angiography. - Source: PubMed
Publication date: 2026/09/22
Murphy KieranLindsay ThomasTan KongtengLau SeanElias GavinLuke KieranNederveen JoshXhuti DonaldMinhas MahekLok BenjaminZhu ShusenPron GayleneTarnopolsky Mark - Although dysregulation of the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) and the STAT3 activation has been linked to tumorigenesis, it is unclear how ANAPC7 (a subunit of APC/C) mediates the link between STAT3 and triple-negative breast cancer (TNBC). In this study, ANAPC7 expression in fresh TNBC and adjacent normal tissues were analyzed, and the correlation of high ANAPC7 expression with clinical pathological features and prognosis in TNBC patients was further tested. Gain- and loss-of-function, xenograft tumor model, co-immunoprecipitation assay, and ubiquitination studies were employed to elucidate the role and underlying mechanisms of ANAPC7-mediated STAT3 activity in TNBC. We showed thatANAPC7 expression was significantly elevated in TNBC tissues, and high ANAPC7 expression was correlated with clinical severity in TNBC patients. Moreover, gain- and loss-of-function experiments showed that ANAPC7 facilitates malignant progression of TNBC cells, which was also verified in a xenograft tumor model. Mechanistically, ANAPC7 promotes the ubiqui-tin-proteasome degradation of tumor suppressor PCGF2 through dependence on ANAPC2, which in turn abrogates the suppression of STAT3 activity by PCGF2, finally increased STAT3 phosphorylation, along with upregulated the expression of c-Myc, N-cadherin, Vimentin and downregulation of E-cadherin. Additionally, both restoration of PCGF2 and pharmacological inhibition of STAT3 can reverse ANAPC7-induced malignant progression of TNBC. These findings revealed how ANAPC7 coordinates ubiquitin-proteasome system to activate STAT3 signaling and exert oncogenic functions, offering new avenues to improve prognosis and treatment in TNBC. Implications: Our findings provide a rationale for further investigation of the ANAPC7-PCGF2-STAT3 axis as a potential therapeutic target in TNBC. - Source: PubMed
Publication date: 2026/09/22
Wang XiaoranHao RanDiao MingxinMa DongZhang HongyuWang YingzhanHu JieQi Yixin - The establishment of endometrial receptivity is a fundamental prerequisite for successful embryo implantation and the maintenance of pregnancy. Decidualization, a critical process in the maturation of endometrial receptivity, is intimately linked to implantation success. The precise molecular regulation of both processes is essential for normal pregnancy outcomes. Within the endometrium, the activation of the transcription factor signal transducer and activator of transcription 3 (STAT3) exhibits strict temporal and spatial specificity. Its phosphorylation levels peak during the mid-secretory phase, aligning perfectly with the window of implantation, thereby establishing STAT3 as a primary indicator of endometrial receptivity. Activated by crucial cytokines-including leukemia inhibitory factor (LIF), interleukin (IL)-11, and epidermal growth factor (EGF)-STAT3 operates through the Janus kinase (JAK)/STAT signaling pathway. It regulates the functional maturation, adhesive capacity, and polarity remodeling of endometrial epithelial cells, creating an optimal environment for blastocyst attachment. Concurrently, STAT3 acts as a central regulator of decidualization by directly driving the proliferation and differentiation of endometrial stromal cells (ESCs) while maintaining the stability of the decidual microenvironment. Furthermore, STAT3 modulates the local immune milieu by orchestrating immune cell polarization and cytokine networks, providing essential immunological support. Conversely, dysregulation of the STAT3 signaling pathway leads to impaired endometrial receptivity and defective decidualization, contributing to adverse reproductive outcomes such as implantation failure and miscarriage. This review comprehensively highlights the pivotal regulatory functions of the STAT3 pathway in endometrial receptivity and decidualization, establishing a robust theoretical foundation for future basic research and targeted clinical strategies. - Source: PubMed
Publication date: 2026/09/22
Zhao HongZou ZongyuanYang Yihua - Cancer remains the leading cause of death globally. Conventional cancer treatments are capable of effectively targeting tumor cells; however, they might trigger immunosuppression, multidrug resistance, and harm healthy cells. Polyphenols are nutraceuticals-based naturally occurring phytochemicals with promising nutraceutical, antioxidant, antineoplastic, anti-inflammatory, and free-radical scavenging properties. This review highlights strategies for encapsulating them within hybrid nanostructures to overcome their limitations of poor aqueous solubility, low bioavailability, and lack of target specificity. Moreover, it provides insights into the major molecular signaling pathways underlying the anticancer activity of polyphenols and their hybrid nanoformulations. - Source: PubMed
Publication date: 2026/09/18
Bhandari SaloniBaniya BhuvaneshSingh SupriyaChoudhary DeepakJain C PJoshi Garima - Corynoline is a naturally occurring benzophenanthridine-derived alkaloid widely isolated from plants of the genus Corydalis, which have been used for centuries in traditional herbal medicine for the management of inflammation, pain, and infectious diseases. Belonging to the structurally unique benzophenanthridine class, corynoline possesses a distinctive chemical scaffold that underlies its diverse and potent biological interactions. In recent years, a growing body of experimental studies has demonstrated that corynoline exhibits a remarkably wide range of pharmacological activities, including anti-inflammatory, anticancer, neuroprotective, hepatoprotective, cardioprotective, anti-osteoporotic, and renal ischemia-reperfusion protective effects. These multifaceted activities are mediated through the modulation of several cellular signaling pathways, including Nrf2/HO-1, MAPKs, NF-κB, NOS3, AKT/GSK3β/Nrf2, STAT3/Bcl-2, and Src/JNK, highlighting its capacity to simultaneously target multiple disease-relevant molecular networks. This review aims to comprehensively summarize current knowledge regarding the chemical characteristics, pharmacological activities, underlying molecular mechanisms, and therapeutic prospects of corynoline. Despite its promising pharmacological profile, the clinical translation of corynoline remains hindered by insufficient pharmacokinetic data, limited bioavailability studies, and inadequate toxicity evaluations. Therefore, further rigorous preclinical and clinical investigations are warranted to fully elucidate its safety profile, therapeutic efficacy, and drug-like properties. By integrating mechanistic insights with translational perspectives, this article seeks to stimulate future research aimed at harnessing corynoline's unique chemical scaffold for the development of innovative and effective therapeutic strategies across multiple disease domains. - Source: PubMed
Publication date: 2026/09/18
Tailor Navin Kumar