AQP3_BOVIN AQP3 ELISA tesk kit
- Known as:
- AQP3_BOVIN AQP3 Enzyme-linked immunosorbent assay test tesk reagent
- Catalog number:
- gen8450
- Product Quantity:
- 1
- Category:
- Peptides
- Supplier:
- EIAab
- Gene target:
- AQP3_BOVIN AQP3 ELISA tesk kit
Related genes to: AQP3_BOVIN AQP3 ELISA tesk kit
- Gene:
- AQP3 NIH gene
- Name:
- aquaporin 3 (Gill blood group)
- Previous symbol:
- -
- Synonyms:
- GIL
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-25
- Date modifiied:
- 2019-04-23
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- Aquaporins (AQPs) are a family of water channel proteins with a significant role in immune cell function. Although aquaporins have been studied in sepsis, their expression in critical illness remains underexplored. Our group aimed to examine the mRNA expression profile of AQP isoforms in polymorphonuclear (PMN) and peripheral blood mononuclear cells (PBMCs) of critically ill patients admitted to the intensive care unit (ICU). To this end, we designed a prospective, longitudinal, observational study performed in the ICU of "Evangelismos" General Hospital between February 2024 and October 2024. In total, 40 critically ill patients and 25 healthy controls were enrolled in the study. Blood samples were collected at four time points: upon ICU admission (24-48h), and at days 4 (D4), 8 (D8), and 14 (D14). Total RNA was extracted from PMNs and PBMCs, and RT-qPCR was performed to examine mRNA levels of AQPs 1, 2, 3, 4, 5, 7, and 9. Our results revealed downregulation of AQP isoforms, except AQP1, in PMNs, whereas PBMCs exhibited sustained upregulation of all AQPs except AQP3, which was downregulated. Our findings suggest that differential AQP expression in immune cell subsets may reflect adaptive immune responses during critical illness, providing insights into leukocyte function and potential therapeutic targets. - Source: PubMed
Publication date: 2026/06/02
Lotsios Nikolaos SIssaris VasileiosPoupouzas GeorgiosVrettou Charikleia SKeskinidou ChrysiKardara MatinaPapavassiliou Kostas AEconomidou FoteiniKokkoris SteliosKotanidou AnastasiaDimopoulou IoannaVassiliou Alice G - Ultraviolet B (UVB) radiation is a major environmental threat that disrupts skin integrity and drives inflammatory skin disorders. Neoagarotetraose (NA4), a low-molecular-weight oligosaccharide derived from marine red algae, is characterized by high bioavailability and well-documented anti-inflammatory properties, yet its role in UVB-induced skin damage remains unexplored. In this study, we investigated the reparative effects of NA4 and its underlying mechanisms using UVB-irradiated HaCaT keratinocytes and C57BL/6 mouse models, with focus on cytotoxicity, cell viability, barrier protein expression, pro-inflammatory cytokines, and MAPK pathway activation. Our results demonstrate that NA4 was non-cytotoxic and dose-dependently restored the viability of UVB-damaged keratinocytes. Notably, NA4 reestablished the expression of key barrier proteins (FLG, ZO-1, COL-I) and corrected UVB-induced elevation of aquaporin-3 (AQP3), while concurrently suppressing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and inhibiting the phosphorylation of JNK, ERK1/2, and p38 in both cell and animal models. In vivo, the 2 mg/cm² NA4 treatment achieved superior barrier restoration and anti-inflammatory effects compared to vitamin C. Collectively, these findings identify NA4 as a concentration-dependent, multi-target marine-derived oligosaccharide that concurrently exerts MAPK-mediated anti-inflammatory activity and barrier-restorative effects, offering a mechanistic basis for developing next-generation marine therapeutics against UVB-induced skin damage. - Source: PubMed
Publication date: 2026/06/04
Wu NanWu ChaochengLiu XiaoYang ZiyiChan ZhuhuaZeng Runying - Aquaporins (AQPs) are membrane proteins that facilitate the transport of small molecules such as water, glycerol, and urea. In mammals, 13 AQP isoforms (AQP0 to AQP12) exhibit tissue-specific expression. Over the past two decades, aquaporins (AQPs) have received considerable attention for their role in tumor biology. Squamous cell carcinoma (SCC) originates from stratified squamous cells and commonly affects the skin and oral cavity. SCC is prevalent in dogs and cats; however, no studies have reported an association between SCC and AQPs in these species. This study investigated the immunohistochemical expression of AQP1, AQP3, AQP5, E-cadherin, and Ki-67 in cutaneous and oral SCCs of dogs and cats. AQP1 and AQP5 were not expressed in tumor cells. In contrast, AQP3 and E-cadherin localized to the plasma membrane, primarily within island-like structures in both cutaneous and oral SCCs. Ki-67-positive cells appeared in small group and cord structures within tumor regions exhibiting reduced AQP3 expression. Therefore, AQP3 expression may be down-regulated in malignant tumor cells in SCCs of dogs and cats. These findings indicate that AQP3 may serve as a novel biomarker for assessing malignancy in SCCs of dogs and cats. - Source: PubMed
Publication date: 2026/06/04
Sonoda HirokoTaniguchi YoshikiFujimoto NarukiHigashijima YoshikiMatsuzaki ToshiyukiHirai TakuyaItoh TeruoUchida KazuyukiIkeda Masahiro - Constipation is a common gastrointestinal disorder, and current treatments often have limitations. Shengdu Pingmu Formula (SDPF), a modified formulation derived from Traditional Chinese Medicine, has been used clinically to treat constipation, but its mechanism of action remains unclear. This study employed UPLC-Q/TOF-MS analysis to identify 188 compounds in SDPF, of which 50 were conclusively confirmed. In animal experiments, SDPF treatment significantly enhanced intestinal propulsion, increased fecal water content, and shortened the time to first black stool. Network pharmacology and molecular docking analyses suggested the involvement of the PI3K/AKT pathway, which was subsequently validated by observed upregulation of this pathway and increased expression of AQP3 and AQP8 in the rectum. Furthermore, 16S rRNA gene sequencing revealed that SDPF restored gut microbiota homeostasis by elevating beneficial bacteria such as Lactobacillus and Bacteroides while reducing bacteria associated with inflammation. Collectively, SDPF effectively alleviates constipation through mechanisms that regulate the PI3K/AKT pathway and modulate gut microbiota. - Source: PubMed
Publication date: 2026/05/12
Wang BeibeiLi FanglanChen HaoyangDai RuijieChen LingzhiLi WeilinZhao Xiangdong - This study evaluated the anti-acne potential of extracellular proteins derived from Lactobacillus gasseri (LG-EPs) by integrating physicochemical characterization, antibacterial assessment, cellular assays, and an in vivo sebaceous gland model. LG-EPs were obtained by ammonium sulfate precipitation and characterized using gel permeation chromatography/light scattering (GPC/LS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The molecular weight of LG-EPs was mainly distributed between 1.0 × 10⁴ and 2.0 × 10⁴ g/mol, and peptide analysis identified four peptides with antimicrobial potential and twelve peptides with antioxidant potential. LG-EPs exhibited direct antibacterial activity against acne-associated bacteria, with MIC and MBC values of 600 µg/mL against Cutibacterium acnes and MIC and MBC values of 700 µg/mL and 1 mg/mL, respectively, against Staphylococcus aureus. Growth-curve and biofilm adhesion assays further showed that LG-EPs inhibited bacterial proliferation and adhesion. In LPS-stimulated HaCaT cells, LG-EPs reduced the secretion of pro-inflammatory cytokines, including IL-6, IL-8, IL-1β, and TNF-α, while increasing the expression of barrier-related factors such as AQP3, FLG, and LOR. In a golden hamster model, topical LG-EP treatment decreased sebum production and downregulated the transcription of lipogenesis-related genes, including SREBP-1, FAS, and ACC1. These effects were associated with reduced transcript levels of PI3K, AKT, and mTOR, while the anti-sebum effect was accompanied by increased AMPK transcription. Overall, LG-EPs showed multi-target anti-acne potential through antibacterial, anti-inflammatory, barrier-protective, and sebum-suppressive effects. - Source: PubMed
Publication date: 2026/06/01
Song ZixinYuan QinxuanFang YifanZhai BianbianGeng JimanLi MengWang ChangtaoWang Dongdong