Anti - Mouse, MUM-1 Clone MUM1p
- Known as:
- Anti - Mouse, MUM-1 Clone MUM1p
- Catalog number:
- 60-0136
- Product Quantity:
- 6 mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Mouse MUM-1 Clone MUM1p
Related genes to: Anti - Mouse, MUM-1 Clone MUM1p
- Gene:
- IRF4 NIH gene
- Name:
- interferon regulatory factor 4
- Previous symbol:
- MUM1
- Synonyms:
- LSIRF
- Chromosome:
- 6p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-05-31
- Date modifiied:
- 2015-11-18
- Gene:
- PWWP3A NIH gene
- Name:
- PWWP domain containing 3A, DNA repair factor
- Previous symbol:
- MUM1
- Synonyms:
- MUM-1, EXPAND1
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-12
- Date modifiied:
- 2018-10-19
- Gene:
- PWWP3B NIH gene
- Name:
- PWWP domain containing 3B
- Previous symbol:
- MUM1L1
- Synonyms:
- FLJ33516
- Chromosome:
- Xq22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-15
- Date modifiied:
- 2018-10-19
Related products to: Anti - Mouse, MUM-1 Clone MUM1p
Related articles to: Anti - Mouse, MUM-1 Clone MUM1p
- VISA/MAVS is crucial in antiviral innate immunity. Upon RNA virus infection, VISA recruits TBK1 via TRAFs to mitochondria, inducing IRF3 phosphorylation and type I interferons. However, TBK1 recruitment mechanisms via individual TRAFs are unclear. Here, we reveal that PWWP domain-containing 3A (PWWP3A) serves as a negative regulator of RNA virus-triggered signaling. During viral infection, PWWP3A translocates from nucleus to the mitochondria, competing with TRAF6 for binding to VISA, thereby impeding the recruitment of TBK1 and inhibiting IRF3 activation. However, the extent of PWWP3A-mediated inhibition is regulated by the E3 ligase PJA2, which induces PWWP3A degradation post-infection, highlighting the intricate regulatory network in antiviral immunity. Consistently, PWWP3A deficiency enhances antiviral responses, and Pwwp3a mice exhibit elevated levels of type I interferons and displayed greater resistance following RNA virus infection. Together, our findings unveil the inhibitory role of PWWP3A in virus-triggered signaling, which provides insights into preventing excessive immune responses. - Source: PubMed
Publication date: 2025/05/01
Shi MenglingWang CongChen ZhenZhou YidanYue LiangLiu YuGuo TiannanShang JunXu HaotianZhang YuLuo MengchengLei Caoqi - The PWWP domain-containing proteins are involved in chromatin-associated biological processes, including transcriptional regulation and DNA repair, and most of them are significant for gametogenesis and early embryonic development in mammals. PWWP3A, one of the PWWP domain proteins, is a reader of H3K36me2/H3K36me3 and a response factor to DNA damage. However, the physiological role of PWWP3A in spermatogenesis and fertility remains unclear. - Source: PubMed
Publication date: 2024/10/03
Chen ZhenLiu CongQu WeiHan YanZhu XiaoyuLi ZejiaMa DupengHuang MengyaGong WeihaoSun QiLei JunhaoGuo RuiLuo Mengcheng - CD5-positive follicular lymphoma (FL), although rare, has been described in a number of case reports. However, a statistically valid, clinicopathological comparison between CD5-positive FL and CD5-negative FL has never been performed because of its rarity. We statistically compared clinicopathological characteristics of 22 cases of CD5-positive FL, diagnosed by immunohistochemistry, flow cytometry and morphological findings, with those of 62 cases of FL without CD5 expression (control cases). CD5-positive FL patients showed a higher tendency of peripheral blood involvement (P = 0.076) and a higher frequency of CD25 expression (P = 0.0004) and MUM1 protein expression (P = 0.0008), and a lower frequency of t(14;18)(q32;q21) (P = 0.017). The overall survival (OS) curve of CD5-positive FL was significantly worse than that of control cases (P = 0.0266), although progression-free survival curves did not show a significant difference (P = 0.7899). Moreover, CD5 expression was shown to be an independent poor prognostic factor for OS in both univariate analysis [Hazard Ratio (HR), 3.63; P = 0.0464] and multivariate analysis (HR, 57.16; P = 0.0001). CD5-positive FL showed different clinicopathological characteristics from FL lacking CD5 expression. These results suggest that CD5-positive FL should be considered a different type of FL, and its clinicopathological management should be conducted differently. - Source: PubMed
Miyoshi HiroakiSato KensakuYoshida MakiKimura YoshizoKiyasu JunichiIchikawa AyakoIshibashi YukinaoArakawa FumikoNakamura YukihikoNakashima ShinjiNiino DaisukeSugita YasuoOhshima Koichi - To determine the correlation between the expression of CARMA1 mRNA and MUM1 protein, as well as its effects on clinicopathological features and prognosis of diffuse large B cell lymphoma (DLBCL). - Source: PubMed
Chen Yu-meiYang Wen-xiuMeng QingZhong Yu - The mammalian interphase chromatin responds to DNA damages by altering the compactness of its architecture, thereby permitting local access of DNA repair machineries. Adding to the cellular strategies of chromatin remodeling following DNA damage, our recent work identified the 53BP1-EXPAND1 module in promoting chromatin dynamics in response to DNA double-strand breaks. Endowed with a nucleosome-binding PWWP domain, EXPAND1 tethers to the chromatin where it is involved in maintaining basal chromatin accessibility in unperturbed cells. Interestingly, through its direct interaction with the DNA damage mediator protein 53BP1, EXPAND1 accumulates at the damage-modified chromatin and triggers its further decondensation. These observations, together with the fact that EXPAND 1 promotes cell survival following DNA damage, suggest that the chromatin-bound factor may facilitate DNA repair by regulating the organization of chromatin structure. - Source: PubMed
Publication date: 2010/07/18
Sy Shirley MhChen JunjieHuen Michael Sy