Anti - Mouse, MyoD1 Clone 5.8A
- Known as:
- Anti - Mouse, MyoD1 Clone 5.8A
- Catalog number:
- 61-0101-2
- Product Quantity:
- 0.2mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Mouse MyoD1 Clone 5.8A
Related genes to: Anti - Mouse, MyoD1 Clone 5.8A
- Gene:
- CCNQ NIH gene
- Name:
- cyclin Q
- Previous symbol:
- FAM58A
- Synonyms:
- -
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-19
- Date modifiied:
- 2017-07-14
- Gene:
- CCNQP2 NIH gene
- Name:
- CCNQ pseudogene 2
- Previous symbol:
- FAM58AP1, FAM58CP
- Synonyms:
- FAM58Y
- Chromosome:
- Yq12
- Locus Type:
- pseudogene
- Date approved:
- 2010-05-11
- Date modifiied:
- 2018-02-20
- Gene:
- EMC9 NIH gene
- Name:
- ER membrane protein complex subunit 9
- Previous symbol:
- C14orf122, FAM158A
- Synonyms:
- CGI-112
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-17
- Date modifiied:
- 2014-11-19
- Gene:
- KIR2DL1 NIH gene
- Name:
- killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
- Previous symbol:
- -
- Synonyms:
- cl-42, nkat1, 47.11, p58.1, CD158A
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-11-09
- Gene:
- MYOD1 NIH gene
- Name:
- myogenic differentiation 1
- Previous symbol:
- MYF3
- Synonyms:
- PUM, MYOD, bHLHc1
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-07-22
Related products to: Anti - Mouse, MyoD1 Clone 5.8A
Related articles to: Anti - Mouse, MyoD1 Clone 5.8A
- Anorectal malformation (ARM) is the most common congenital digestive tract anomaly in newborns, and children with ARM often have varying degrees of underdevelopment of the pelvic floor muscles (PFMs). To explore the effects of Rarα (NR1B1) and Pitx2 on the development of rat PFMs, we constructed a rat ARM animal model using all-trans retinoic acid (ATRA), and verified the expression of Rarα and Pitx2 in the PFMs of fetal rats. Additionally, we used rat myoblasts (L6 cells) to investigate the regulatory roles of Rarα and Pitx2 in skeletal muscle myoblast differentiation and their interactions. The results indicated a significant decrease in the expression of Rarα and Pitx2 in the PFMs of fetal rats with ARM. ATRA can also decrease the expression of Rarα and Pitx2 in the L6 cells, while affecting the differentiation and fusion of L6 cells. Knocking down Rarα in L6 cells reduced the expression of Pitx2, Myod1, Mymk, and decreased myogenic activity in L6 cells. When Rarα is activated, the decreased expression of Pitx2, Myod1, and Mymk and myogenic differentiation can be restored to different extents. At the same time, increasing or inhibiting the expression of Pitx2 can counteract the effects of knocking down Rarα and activating Rarα respectively. These results indicate that Pitx2 may be downstream of the transcription factor Rarα, mediating the effects of ATRA on the development of fetal rat PFMs. - Source: PubMed
Publication date: 2026/04/17
Zhao HanbinCao JianMu HuaqiBi YangGuo ZhenhuaShi YuanWang Yi - Spindle cell and sclerosing rhabdomyosarcoma (Sc/SRMS) are rare histologic subtypes of rhabdomyosarcoma, increasingly recognized for their distinct molecular profiles and aggressive clinical behavior. Retroperitoneal involvement is exceptionally uncommon and poorly characterized. To characterize the clinical, pathological, and molecular features of retroperitoneal Sc/SRMS through a combined institutional case series and individual patient data (IPD) meta-analysis. - Source: PubMed
Publication date: 2026/04/01
Zhang XiaoyingZheng HainingZhang Ming - IntroductionPrimary sarcoma of the prostate is extremely rare and accounts for less than 1% of all prostatic malignancies. Alveolar rhabdomyosarcoma arising from the prostate in an adult man is exceedingly rare. Establishing a correct diagnosis is often challenging in a prostatic core biopsy.Patient presentationA 30-year-old man presented to the emergency department after a period of acute urinary retention. Clinical examination revealed an indurated prostatic mass. Serum prostate-specific antigen level was normal. Imaging work-up showed pelvic lymph node and vertebral metastases. A malignant pleural effusion was noted. Transrectal ultrasound-guided core biopsy from the prostate revealed a cellular malignant neoplasm with small round tumor cells arranged in nests and sheets. Initial diagnosis of prostatic adenocarcinoma, Gleason score 5 + 5, grade group 5 was made. Immunohistochemical work-up showed positive skeletal muscle markers (desmin, myogenin and MYOD1) with negative keratin (AE1/AE3), NKX3.1, synaptophysin, chromogranin. CD56 showed patchy positivity. A revised diagnosis of primary alveolar rhabdomyosarcoma was established. The patient succumbed to the disease soon after the diagnosis.DiscussionPrimary alveolar rhabdomyosarcoma of the adult prostate has been rarely reported. The tumor has an aggressive clinical course with dismal prognosis. The diagnosis can be challenging as the histomorphology closely resembles poorly differentiated carcinoma, non-Hodgkin lymphoma, small cell carcinoma and other small round cell sarcomas. Aberrant immunohistochemical expression causes diagnostic dilemma. The treatment protocol and adjuvant drugs differ significantly from prostatic adenocarcinoma or small cell carcinoma, necessitating an accurate histological diagnosis for appropriate patient management. A molecular work-up can be useful in challenging specimens. - Source: PubMed
Publication date: 2026/04/16
Mitra SaikatChoube AbhishekRatnaparkhi ChetanaPande Shantanu - Recently, a distinct, bland spindle cell neoplasm with rhabdomyoblastic phenotype, and VGLL3 rearrangement has been described. These tumors have a striking predilection for the head and neck area and so far, followed an indolent course. It remains unclear whether these tumors are best classified as true rhabdomyosarcomas. There are 11 reports of such tumors with limited follow-up. Here, we report an additional case with local recurrence, long-term follow-up and spatial profiling. The tumor occurred in the right buccal mucosa/oral commissure of a 47-year-old man. On clinical examination, the mass was firm, measuring ~1.5 cm. Biopsy and subsequent wedge excision were performed. Histologically, the tumor was composed of bland, small, spindle to ovoid cells, arranged in short fascicles and vaguely storiform architecture. The tumor cells diffusely infiltrated into skeletal muscle. There was a background of inflammatory cells including small lymphocytes and histiocytes. Neoplastic cells were positive for SMA, demsin, PAX7, myogenin and MyoD1. Whole transcriptome sequencing revealed a TCF12::VGLL3 fusion. Digital spatial profiling (DSP) identified pan-AKT expression, differential expression in the MAPK pathway, and revealed that the tumor attracted a dense T-cell rich inflammatory infiltrate. The patient had a lesion in the same location 6 years prior that underwent incisional biopsy, showed intense inflammatory infiltrate, and was interpreted as benign. FISH for VGLL3 on this tissue was positive for rearrangement. No additional adjuvant treatment was given, and the patient is alive without disease, 8 months after the major resection. Long term follow-up of 6 years with only local recurrence lends further support to the notion that these neoplasms are a class of indolent/low-grade rhabdomyoblastic tumors that are biologically and clinically distinct from fully malignant spindle cell rhabdomyosarcomas. - Source: PubMed
Dashti Nooshin KChakraborty DebopriyaSadanandappa Madhumala KDehner Carina AZhang Paul JPaydarfar Joseph ATafe Laura J - - Source: PubMed
Li J LMa T STong J TZhao M