Anti - Rabbit, AMACR Clone 13H4
- Known as:
- Anti - Rabbit, AMACR Clone 13H4
- Catalog number:
- 60-0096
- Product Quantity:
- 6 mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Rabbit AMACR Clone 13H4
Related genes to: Anti - Rabbit, AMACR Clone 13H4
- Gene:
- AMACR NIH gene
- Name:
- alpha-methylacyl-CoA racemase
- Previous symbol:
- -
- Synonyms:
- RACE, P504S
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-19
- Date modifiied:
- 2016-12-13
Related products to: Anti - Rabbit, AMACR Clone 13H4
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- BACKGROUND Primary clear cell carcinoma of the colon is an exceptionally rare condition. It is still uncertain whether this carcinoma represents a separate biological category or simply a variant of typical colorectal cancer. From a diagnostic standpoint, the presence of clear cell morphology introduces significant challenges, as similar features can be observed in various other carcinomas, including renal, ovarian, and endometrial carcinoma. Typically, primary colorectal tumors demonstrate positivity for markers such as CK20 and CDX2, supporting intestinal origin. CASE REPORT We present a case of primary clear cell carcinoma of the sigmoid colon, with no adenoma component, in a 69-year-old woman. The tumor was detected on routine bowel screening colonoscopy, and the patient underwent anterior resection of a pT3N2b sigmoid tumor with prophylactic oophorectomy and salpingectomy. In contrast to the positivity for intestinal-origin markers typically seen in primary colorectal tumors, in this case, the histopathological and immunohistochemical analyses revealed that the tumor was positive for AMACR, CK7, and PAX 8 and negative for WT1, ER, PR, P16, CD10, CDX2, and CK20. These results were consistent with colonic clear cell carcinoma. CONCLUSIONS Specific data on colorectal clear cell carcinoma in Ireland and worldwide are limited. In academic literature, few cases have been documented. The presence of clear cell morphology in colon tumors presents significant diagnostic challenges, necessitating careful radiological and histopathological evaluation, which should be correlated with the patient's clinical history. This case was documented due to the extreme rarity of this condition and the diagnostic difficulties it poses, particularly in distinguishing clear cell carcinoma of the colon from conventional adenocarcinoma. - Source: PubMed
Publication date: 2026/08/07
Ahmed MohamedKhalid Abubaker K SCummins OliveRichards Kate - Renal cysts in autosomal dominant polycystic kidney disease (ADPKD) frequently harbor small intracystic epithelial proliferations that arise in continuity with the cyst lining and are distinct from other recognized proliferative lesions or well-defined renal tumors and lack a formal designation. We aim to provide the histomorphologic, immunohistochemical (IHC), and molecular characteristics of these lesions, determine their incidence, and employ the term papillary hyperplasia (PH), consistent with the recent International Society of Urological Pathology (ISUP) consensus meeting report on precursor lesions of the kidney. A multi-institutional retrospective study of nephrectomies affected by ADPKD was reviewed for PH, histomorphologic features, and clinicopathologic data. PH was defined by intracystic tufted or papillary epithelial proliferations composed of a single layer of bland cuboidal epithelial cells with minimal amphophilic to eosinophilic cytoplasm. IHC stains and molecular analysis using whole-genome sequencing were performed on a subset of cases. Eighty-five nephrectomies from 48 patients demonstrated PH in 88% (75/85) of kidneys. Predominant architectural patterns were tufting (97%), papillary (72%), hobnail (72%), and micropapillary (51%). All PH exhibited low-grade nuclei without atypia, with amphophilic (95%) and/or eosinophilic cytoplasm (63%). The most well-developed PH per case measured 0.3 by 3.1 mm (mean height by width) and occurred within small cysts with an average diameter of 3 mm. PH were positive for KRT7, GATA3, L1CAM, variably positive for AMACR, and negative for CA9 and showed no definitive molecular alterations. PH are common microscopic findings in kidneys affected by ADPKD. PH show a distinct combined histomorphologic, IHC, and molecular profile. - Source: PubMed
Publication date: 2026/08/04
Tanaka Kara SWilliamson Sean RZalles NicoleWu Douglas JAkgul MahmutAl-Obaidy KhaleelChan EmilySangoi Ankur R - Morphological changes in prostate glands, assessed by Gleason grading, remain the gold standard for diagnosing prostate cancer, yet molecular biomarkers associated with gland shape are not well understood. Here, we introduce CurvSeq, a mechanomorphology-informed framework for spatial sequencing data, and CurvSee, its complementary version for proteomic and imaging datasets. These methods integrate gland boundary curvature, pocket architecture, microenvironmental composition, and molecular profiles to study morphomechanical relationships in prostate adenocarcinoma. Using five independent spatial transcriptomic and multiplexed imaging datasets, we segmented individual prostate glands, extracted gland contours, quantified local curvature and pocket-like concavities, and projected these features onto spatially resolved gene and protein measurements. In Xenium data, CurvSeq distinguished benign and GG1 glands, identifying cancer-associated genes such as PCA3 and AMACR in GG1 glands and basal, basement membrane, and mechanotransduction-associated programs in benign glands. In Visium data, a diffusion-based morphomechanical score ordered benign glands by area, circularity, pocket number, smooth muscle abundance, immune-cell proximity, and remodeling-associated genes including MMP7. In GG4 glands, CurvSeq identified neuroendocrine-like boundary regions associated with MMP7 expression, COL1A1-rich adjacent stroma, and immune-cell accumulation. Finally, CurvSee extended this framework to multiplexed protein imaging, where combined morphology and protein-expression features distinguished Gleason-associated gland states. Together, CurvSeq and CurvSee provide a quantitative framework for linking gland architecture, local microenvironment, and molecular state, showing that prostate gland morphology can be integrated with spatial omics to identify morphomechanical niches associated with cancer progression. - Source: PubMed
Publication date: 2026/07/23
Kordic IvanRivera Moctezuma Felix GAmiri Hoseyn ALiu AlanCai ShuangyiRajab Ali Mehdia NadeemBrea LourdesVenkataraman AbhijeetShi HongshunHarik LaraSulchek Todd AYu JindanCoskun Ahmet F - Prostate cancer remains a major cause of cancer-related mortality, and new therapeutic strategies are needed for advanced disease. Niclosamide and related salicylanilide compounds have emerged as multitarget anticancer agents, but the molecular contexts associated with their activity remain incompletely understood. Here, we applied a phenotype-oriented integrative framework to characterize the molecular context and phenotypic activity of NSC828786, a niclosamide-like salicylanilide derivative. Cross-cohort transcriptomic analyses identified AMACR (alpha-methylacyl-CoA racemase) and HPN (hepsin) as consistently upregulated genes in independent prostate adenocarcinoma cohorts. NCI-60 profiling demonstrated broad-spectrum low-micromolar antiproliferative activity, including AR-negative prostate cancer and breast cancer cell lines spanning multiple receptor subtypes; however, quantitative ranking did not support preferential receptor subtype selectivity. CellMiner COMPARE analysis showed no significant correlation between baseline AMACR or HPN expression and NSC828786 sensitivity. Structure-based analyses supported computational compatibility of NSC828786 with predicted HPN- and AMACR-associated binding regions, while zebrafish assays showed no overt developmental abnormalities at concentrations ≤ 5 μM. These findings identify NSC828786 as a phenotypically active salicylanilide derivative and position HPN and AMACR as exploratory candidate molecular associations warranting further mechanistic and target engagement studies. - Source: PubMed
Publication date: 2026/07/22
Wen Ya-TingManalu Rosario TrijuliamosHsu Han-LinKuo Yu-ChengSoong Ruey-ShyangLiu Feng-ChengSumitra Maryam RachmawatiHuang Sheng-LiangLee Shih-YuTang Sung-LingYen I-ChuanWang Hong-JaanLawal BashirWu Alexander T HHuang Hsu-Shan - Low-grade oncocytic tumor (LOT) of the kidney is a rare, indolent neoplasm within the spectrum of eosinophilic renal tumors. It typically presents as a small, solitary mass and is associated with molecular alterations in , , or . We describe a 72-year-old male with a history of pancreatic neuroendocrine tumor, gastrointestinal stromal tumor, and prostate cancer who presented with multiple bilateral renal masses. Partial nephrectomy revealed two distinct tumors: one consistent with LOT and the other with a sclerosing angiomyolipoma (AML). The LOT consisted of oncocytic cells with round to oval nuclei and delicate perinuclear halos, arranged predominantly in solid architecture, and immunoreactive for PAX8, EMA, and CK7, whereas negative for CD117 and AMACR. The AML was composed of spindle and epithelioid cells embedded in sclerotic stroma, positive for MiTF and SMA, and negative for conventional melanocytic markers, including HMB45 and Melan-A. Germline testing identified a intron 6, c.509-15G > A variant of uncertain significance. Somatic analysis showed increased allelic imbalance at the locus, suggesting loss of heterozygosity and a potential pathogenic role. This case adds to the limited reports of multifocal LOT and demonstrates the consistent association of germline alterations with this rare tumor presentation. - Source: PubMed
Publication date: 2026/07/16
Putra IlhamVashisht TanishqOrdobazari AtousaVosoughi Aram