Anti - Mouse, CD79a Clone JCB117
- Known as:
- Anti - Mouse, CD79a Clone JCB117
- Catalog number:
- 60-0095-7
- Product Quantity:
- 7mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Mouse CD79a Clone JCB117
Related genes to: Anti - Mouse, CD79a Clone JCB117
- Gene:
- CD79A NIH gene
- Name:
- CD79a molecule
- Previous symbol:
- IGA
- Synonyms:
- MB-1
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-07-31
- Date modifiied:
- 2019-04-23
Related products to: Anti - Mouse, CD79a Clone JCB117
Related articles to: Anti - Mouse, CD79a Clone JCB117
- Ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) is driven by both genetic and immune microenvironmental factors, yet its pathogenic mechanisms remain incompletely understood. We previously identified IGLL5 as a recurrently mutated gene associated with poor prognosis in OAML. Functional and mechanistic analyses focusing on the S47G and A54G mutants show that these variants enhance association with the CD79A/CD79B complex, leading to persistent B-cell receptor (BCR) signaling. This signaling is accompanied by upregulation of CXCL10 and CXCL11, increased CD8 T cell recruitment, and an exhaustion-associated dysfunctional phenotype that may contribute to an immune-tolerant microenvironment. Pharmacologic inhibition further shows that combined BTK inhibitor and rituximab treatment suppresses IGLL5-associated BCR activation. Together, these findings support a mutation-associated mechanism in a subset of OAML and nominate IGLL5-related signaling as a potential therapeutic vulnerability. - Source: PubMed
Publication date: 2026/05/12
Zhao AndiWei HaoyuZhou ChenyuSun XinpingDa ShuyanLiu HaiyuWang ZijinZhu HuiShen ShiyaShao QingGong QiLiu HuChen Xuejuan - Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive tract of heifers four months after experimental infection following prior immunization. Thirty-three heifers were randomly assigned to three groups (n = 11 each): two vaccinated groups receiving inactivated bacterin formulations and a non-vaccinated control group. All animals were experimentally challenged intravaginally with a regional Cfv strain. At four months post-infection, cervicovaginal mucus and reproductive tissues were collected for bacteriological culture, histopathology, and immunohistochemistry. Cfv was recovered in all experimental groups. Although non-vaccinated heifers showed a higher frequency of positive cultures and immunohistochemistry detection, vaccinated animals also remained culture-and IHC-positive at four months post‑infection, suggesting that vaccination did not induce sterilizing immunity and did not prevent persistence of Cfv within the reproductive tract Immunohistochemistry localized Cfv in the vaginal mucosa, supporting its role as primary site of long‑term colonization. Histopathological lesions were detected across all groups and were mainly characterized by mild to moderate lymphohistiocytic infiltrates affecting the vagina, cervix, and uterus. Immunophenotyping in vaginal fundus revealed a predominance of CD68⁺ macrophages, with scarce CD3⁺ T lymphocytes and minimal CD79a⁺ B-cell labeling, suggesting a limited and poorly organized mucosal immune response with minimal involvement of adaptive immune cell populations. Overall, these findings demonstrate that Cfv persists in the bovine reproductive tract for at least four months despite prior vaccination. The predominance of macrophage‑dominated inflammation and the absence of sterilizing immunity highlight limitations of current bacterin vaccines and underscore the need for improved vaccination strategies capable of more effectively targeting vaginal mucosal immunity to enhance control of BGC. - Source: PubMed
Publication date: 2026/05/02
Scioli María ValeriaSosa EmilianoBarale JoaquinAzaldegui IgnacioMéndez AlejandraPaolicchi FernandoGarcía Juan Agustín - A 5-year-old female spayed ferret was presented with lameness of the left hind limb and dyspnea. Five months earlier, the animal had been diagnosed with dilated cardiomyopathy and an undifferentiated precardiac mass. Clinical, radiological, and laboratory examinations revealed a left femoral neck fracture, mild anemia, and hyperglobulinemia. Due to the poor general condition and unfavorable prognosis, the animal was euthanized. Pathological examination identified the precardiac mass as multiple myeloma with dissemination to the mediastinum, spleen, liver, kidneys, adrenal glands, lymph nodes, and bone marrow. The neoplastic plasma cells were immunohistochemically CD138-positive and CD3-/CD79a-negative. This case demonstrates that plasma cell neoplasms in ferrets can also present as precardiac masses and should therefore be considered in the differential diagnosis. - Source: PubMed
Publication date: 2026/04/24
Weber MichaelKunder SandraMundhenk Larsvon Pückler KerstinGöbel ThomasMüller Kerstin - Canine transmissible venereal tumour (TVT) is a clonally transmissible round cell neoplasm that most commonly affects the external genitalia. Extragenital and metastatic forms are uncommon and may represent a substantial diagnostic challenge, particularly when genital lesions are absent. We describe a young dog presenting with large unilateral pulmonary masses that clinically and histologically mimicked lymphoma. Histopathology revealed a malignant round cell neoplasm composed of sheets of poorly differentiated round cells. Immunohistochemical evaluation showed diffuse cytoplasmic immunolabelling for vimentin and neuron-specific enolase, while markers of epithelial, neuroendocrine and definitive lymphoid differentiation were negative. Weak cytoplasmic CD79a immunolabelling in a subset of neoplastic cells further complicated interpretation. Despite extensive immunohistochemical profiling and consultation among multiple board-certified pathologists, a definitive diagnosis could not initially be reached. Following recognition of the dog's epidemiological background as an imported stray from Romania, TVT was considered and subsequently confirmed by detection of the characteristic LINE-MYC oncogene rearrangement using polymerase chain reaction. This case highlights an important diagnostic pitfall in pulmonary round cell tumours and emphasises the value of integrating epidemiological information, histopathology, immunohistochemistry and molecular diagnostics when evaluating atypical extragenital presentations of TVT. - Source: PubMed
Publication date: 2026/04/21
Novotny LadislavLangohr Ingeborg MHanshaw DarenBenes Michal - We describe a rare and aggressive case of multiple myeloma (MM) characterized by extensive lymph node involvement, loss of CD138 expression, and adipophilin (ADP)-positive cytoplasmic vacuolization, highlighting the role of lipid metabolism in disease aggressiveness. An 83-year-old woman presented with painless cervical lymphadenopathy and widespread osteolytic lesions. Bone marrow examination confirmed MM, while lymph node biopsy showed diffuse infiltration of atypical lymphoid cells with numerous tingible body macrophages, initially mimicking a high-grade lymphoma. Immunophenotyping showed CD3/CD5/CD20/CD23 negativity, focal CD138/CD79a positivity, diffuse MUM1 and κ-light chain positivity, and a high Ki-67 index. Compared with bone marrow plasma cells, lymph node MM cells exhibited prominent cytoplasmic vacuoles and nuclear enlargement. Immunohistochemistry demonstrated ADP positivity in lymph node lesions but not in bone marrow MM cells, suggesting metabolic reprogramming toward lipid utilization. Despite anti-myeloma therapy, the disease rapidly progressed, and the patient died within two months. This case underscores the clinical significance of CD138 down-regulation as a marker of dedifferentiation and poor prognosis, and suggests that altered lipid metabolism may contribute to the aggressiveness of metastatic MM. To the best of our knowledge, this is the first MM case with lymph node involvement showing CD138 down-regulation and ADP positivity. - Source: PubMed
Publication date: 2026/04/22
Kondo YoshihikoNakabeppu SeiichiroYano HiromuIshitsuka KenjiUrakado TadahitoFujiwara YukioYamamoto MasahiroKarube KennosukeKomohara Yoshihiro