Anti - Mouse, CD79a Clone JCB117
- Known as:
- Anti - Mouse, CD79a Clone JCB117
- Catalog number:
- 60-0095
- Product Quantity:
- 6 mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Anti - Mouse CD79a Clone JCB117
Related genes to: Anti - Mouse, CD79a Clone JCB117
- Gene:
- CD79A NIH gene
- Name:
- CD79a molecule
- Previous symbol:
- IGA
- Synonyms:
- MB-1
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-07-31
- Date modifiied:
- 2019-04-23
Related products to: Anti - Mouse, CD79a Clone JCB117
Related articles to: Anti - Mouse, CD79a Clone JCB117
- A 5-year-old female spayed ferret was presented with lameness of the left hind limb and dyspnea. Five months earlier, the animal had been diagnosed with dilated cardiomyopathy and an undifferentiated precardiac mass. Clinical, radiological, and laboratory examinations revealed a left femoral neck fracture, mild anemia, and hyperglobulinemia. Due to the poor general condition and unfavorable prognosis, the animal was euthanized. Pathological examination identified the precardiac mass as multiple myeloma with dissemination to the mediastinum, spleen, liver, kidneys, adrenal glands, lymph nodes, and bone marrow. The neoplastic plasma cells were immunohistochemically CD138-positive and CD3-/CD79a-negative. This case demonstrates that plasma cell neoplasms in ferrets can also present as precardiac masses and should therefore be considered in the differential diagnosis. - Source: PubMed
Publication date: 2026/04/24
Weber MichaelKunder SandraMundhenk Larsvon Pückler KerstinGöbel ThomasMüller Kerstin - Canine transmissible venereal tumour (TVT) is a clonally transmissible round cell neoplasm that most commonly affects the external genitalia. Extragenital and metastatic forms are uncommon and may represent a substantial diagnostic challenge, particularly when genital lesions are absent. We describe a young dog presenting with large unilateral pulmonary masses that clinically and histologically mimicked lymphoma. Histopathology revealed a malignant round cell neoplasm composed of sheets of poorly differentiated round cells. Immunohistochemical evaluation showed diffuse cytoplasmic immunolabelling for vimentin and neuron-specific enolase, while markers of epithelial, neuroendocrine and definitive lymphoid differentiation were negative. Weak cytoplasmic CD79a immunolabelling in a subset of neoplastic cells further complicated interpretation. Despite extensive immunohistochemical profiling and consultation among multiple board-certified pathologists, a definitive diagnosis could not initially be reached. Following recognition of the dog's epidemiological background as an imported stray from Romania, TVT was considered and subsequently confirmed by detection of the characteristic LINE-MYC oncogene rearrangement using polymerase chain reaction. This case highlights an important diagnostic pitfall in pulmonary round cell tumours and emphasises the value of integrating epidemiological information, histopathology, immunohistochemistry and molecular diagnostics when evaluating atypical extragenital presentations of TVT. - Source: PubMed
Publication date: 2026/04/21
Novotny LadislavLangohr Ingeborg MHanshaw DarenBenes Michal - We describe a rare and aggressive case of multiple myeloma (MM) characterized by extensive lymph node involvement, loss of CD138 expression, and adipophilin (ADP)-positive cytoplasmic vacuolization, highlighting the role of lipid metabolism in disease aggressiveness. An 83-year-old woman presented with painless cervical lymphadenopathy and widespread osteolytic lesions. Bone marrow examination confirmed MM, while lymph node biopsy showed diffuse infiltration of atypical lymphoid cells with numerous tingible body macrophages, initially mimicking a high-grade lymphoma. Immunophenotyping showed CD3/CD5/CD20/CD23 negativity, focal CD138/CD79a positivity, diffuse MUM1 and κ-light chain positivity, and a high Ki-67 index. Compared with bone marrow plasma cells, lymph node MM cells exhibited prominent cytoplasmic vacuoles and nuclear enlargement. Immunohistochemistry demonstrated ADP positivity in lymph node lesions but not in bone marrow MM cells, suggesting metabolic reprogramming toward lipid utilization. Despite anti-myeloma therapy, the disease rapidly progressed, and the patient died within two months. This case underscores the clinical significance of CD138 down-regulation as a marker of dedifferentiation and poor prognosis, and suggests that altered lipid metabolism may contribute to the aggressiveness of metastatic MM. To the best of our knowledge, this is the first MM case with lymph node involvement showing CD138 down-regulation and ADP positivity. - Source: PubMed
Publication date: 2026/04/22
Kondo YoshihikoNakabeppu SeiichiroYano HiromuIshitsuka KenjiUrakado TadahitoFujiwara YukioYamamoto MasahiroKarube KennosukeKomohara Yoshihiro - The canine transmissible venereal tumor (CTVT) is a naturally occurring clonal cancer that offers a unique model to study tumor evolution, immune evasion, and chemoresistance. Although vincristine induces complete remission in most cases, some tumors show partial response or resistance, and the molecular drivers of this variability remain unclear. While genomic and epigenetic studies have implicated multidrug resistance and immune modulation, transcriptional mechanisms underlying therapeutic outcomes are not fully characterized. - Source: PubMed
Publication date: 2026/04/15
López-Valbuena Fabián DOsorio-Zambrano William FDebiaso Rossi André LMontoya-Flórez Luis MRocha Noeme S - ObjectivesTarsal tumors are rare, but previous reports suggest a predilection for round cell tumors (RCTs) and soft tissue sarcomas (STSs) in this region. This study aimed to determine the proportion of RCTs among feline tarsal neoplasms, refine classification through histologic revision and immunohistochemistry (IHC), assess potential risk factors, and evaluate clinical outcomes based on tumor histotypes.MethodsA retrospective analysis of feline tarsal neoplasms diagnosed between 2010 and 2024 was conducted. Signalment, history, treatment, and outcomes were collected for RCTs and STSs. All RCTs underwent histologic review and IHC (CD3, CD20, CD79a, MUM-1, CD18, IBA-1, E-CAD). A diagnostic algorithm was applied to support the diagnostic process.ResultsThirty-four cases were included: 18 RCTs and 16 STSs. In 39% of RCTs, the initial histotype was undetermined. Following IHC and application of the diagnostic algorithm, 50% of cases were reclassified: seven plasma cell tumors, four progressive histiocytosis, three lymphomas, two histiocytic sarcomas and two undifferentiated RCTs. Male sex, older age and prior tarsal trauma were significantly associated with RCTs (P=0.042, P=0.048, and P=0.009, respectively). Clinical signs and metastases at diagnosis were more frequent in RCTs (P=0.019 and P=0.001, respectively). RCT treatment included chemotherapy (n=7), surgery (n=5), surgery and chemotherapy (n=2), prednisolone (n=1), or none (n=1); two cases lacked treatment data. All STSs were managed surgically without chemotherapy. Time to progression and median survival were significantly shorter for RCTs compared to STSs (139 vs 854 days; 173 vs not reached, respectively; P<0.001).Conclusions and relevanceThis study confirms that feline tarsal RCTs are a heterogeneous group of tumors with a poor prognosis. Risk factors may include male sex, older age, and previous tarsal trauma. A standardized IHC panel combined with a diagnostic algorithm improved histotyping accuracy and should be adopted in clinical practice. - Source: PubMed
Publication date: 2026/04/17
Lollo GianmarcoSabattini SilviaFoiani GretaVascellari MartaRigillo AntonellaMelchiotti EricaMarconato Laura